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Coexpression cluster:C4762

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Full id: C4762_Endothelial_Wilms_mature_Renal_endometrioid_Smooth_Lymphatic



Phase1 CAGE Peaks

  Short description
Hg19::chr8:55370487..55370503,+ p1@SOX17
Hg19::chr8:55370693..55370704,+ p4@SOX17
Hg19::chr8:55370720..55370733,+ p2@SOX17


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
mesodermal cell4.18e-32121
endothelial cell of vascular tree8.94e-3024
endothelial cell1.13e-2836
vascular associated smooth muscle cell5.32e-2832
blood vessel endothelial cell4.91e-2318
embryonic blood vessel endothelial progenitor cell4.91e-2318
meso-epithelial cell3.13e-2245
lining cell1.23e-2058
barrier cell1.23e-2058
smooth muscle cell3.98e-1843
smooth muscle myoblast3.98e-1843
muscle cell3.22e-1555
electrically responsive cell1.26e-1461
electrically active cell1.26e-1461
contractile cell1.79e-1459
muscle precursor cell6.90e-1458
myoblast6.90e-1458
multi-potent skeletal muscle stem cell6.90e-1458
aortic smooth muscle cell5.73e-1310
endothelial cell of artery1.68e-129
embryonic cell1.79e-10250
cardiocyte1.54e-0916
aortic endothelial cell8.24e-096
vein endothelial cell1.42e-086
lymphangioblast2.80e-086
endothelial cell of lymphatic vessel2.80e-086
vascular lymphangioblast2.80e-086
smooth muscle cell of the subclavian artery3.96e-075
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm1.44e-6583
vessel3.30e-6068
epithelial tube open at both ends7.27e-5759
blood vessel7.27e-5759
blood vasculature7.27e-5759
vascular cord7.27e-5759
vasculature2.43e-5178
vascular system2.43e-5178
epithelial tube1.25e-50117
circulatory system1.54e-48112
cardiovascular system8.12e-48109
artery1.96e-4742
arterial blood vessel1.96e-4742
arterial system1.96e-4742
systemic artery2.10e-3633
systemic arterial system2.10e-3633
tube6.93e-32192
anatomical conduit4.93e-28240
blood vessel endothelium4.91e-2318
endothelium4.91e-2318
cardiovascular system endothelium4.91e-2318
aorta2.20e-2221
aortic system2.20e-2221
simple squamous epithelium8.99e-2222
unilaminar epithelium2.15e-20148
anatomical cluster8.01e-19373
squamous epithelium2.95e-1825
lateral plate mesoderm4.69e-17203
mesoderm3.60e-16315
mesoderm-derived structure3.60e-16315
presumptive mesoderm3.60e-16315
epithelium6.55e-16306
cell layer1.79e-15309
epithelial vesicle1.09e-1378
primary circulatory organ1.83e-1327
skeletal muscle tissue3.73e-1362
striated muscle tissue3.73e-1362
myotome3.73e-1362
heart5.42e-1324
primitive heart tube5.42e-1324
primary heart field5.42e-1324
anterior lateral plate mesoderm5.42e-1324
heart tube5.42e-1324
heart primordium5.42e-1324
cardiac mesoderm5.42e-1324
cardiogenic plate5.42e-1324
heart rudiment5.42e-1324
blood vessel smooth muscle5.73e-1310
arterial system smooth muscle5.73e-1310
artery smooth muscle tissue5.73e-1310
aorta smooth muscle tissue5.73e-1310
endothelial tube1.68e-129
arterial system endothelium1.68e-129
endothelium of artery1.68e-129
muscle tissue2.03e-1264
musculature2.03e-1264
musculature of body2.03e-1264
trunk mesenchyme2.22e-12122
somite4.66e-1171
presomitic mesoderm4.66e-1171
presumptive segmental plate4.66e-1171
dermomyotome4.66e-1171
trunk paraxial mesoderm4.66e-1171
paraxial mesoderm9.19e-1172
presumptive paraxial mesoderm9.19e-1172
dense mesenchyme tissue1.78e-1073
compound organ8.05e-1068
trunk blood vessel1.28e-097
mesenchyme4.89e-09160
entire embryonic mesenchyme4.89e-09160
female gonad6.12e-0913
anatomical system6.70e-09624

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.17.68548
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.13.90467
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.990225
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.11.84783
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.14.51393
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.22.15877
MA0138.22.38017
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.21.34467
MA0065.21.39232
MA0150.11.76247
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.25.16052
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488241.81133355955210.0007543408259914850.00593689536742462
SUZ12#23512350.11578091106297.93834897779404e-060.000223711070936814
TFAP2C#7022310.80922860986020.0007916746575753130.006193386484083



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.