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{{Coexpression_clusters
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guanyl-nucleotide exchange factor activity!0.0288031319910514!10276$GO:0035023!regulation of Rho protein signal transduction!0.0288031319910514!10276$GO:0001558!regulation of cell growth!0.0288031319910514!10276$GO:0005088!Ras guanyl-nucleotide exchange factor activity!0.0288031319910514!10276$GO:0007266!Rho protein signal transduction!0.0288031319910514!10276$GO:0016049!cell growth!0.0288031319910514!10276$GO:0040008!regulation of growth!0.0288031319910514!10276$GO:0008361!regulation of cell size!0.0288031319910514!10276$GO:0005085!guanyl-nucleotide exchange factor activity!0.0356450410141685!10276$GO:0046578!regulation of Ras protein signal transduction!0.0356450410141685!10276$GO:0007265!Ras protein signal transduction!0.0356450410141685!10276$GO:0005083!small GTPase regulator activity!0.0356450410141685!10276$GO:0051056!regulation of small GTPase mediated signal transduction!0.0356450410141685!10276$GO:0032989!cellular structure 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|full_id=C3026_medulla_aorta_optic_spinal_locus_corpus_skeletal
|gostat_on_coexpression_clusters=GO:0005089!Rho guanyl-nucleotide exchange factor activity!0.0288031319910514!10276$GO:0035023!regulation of Rho protein signal transduction!0.0288031319910514!10276$GO:0001558!regulation of cell growth!0.0288031319910514!10276$GO:0005088!Ras guanyl-nucleotide exchange factor activity!0.0288031319910514!10276$GO:0007266!Rho protein signal transduction!0.0288031319910514!10276$GO:0016049!cell growth!0.0288031319910514!10276$GO:0040008!regulation of growth!0.0288031319910514!10276$GO:0008361!regulation of cell size!0.0288031319910514!10276$GO:0005085!guanyl-nucleotide exchange factor activity!0.0356450410141685!10276$GO:0046578!regulation of Ras protein signal transduction!0.0356450410141685!10276$GO:0007265!Ras protein signal transduction!0.0356450410141685!10276$GO:0005083!small GTPase regulator activity!0.0356450410141685!10276$GO:0051056!regulation of small GTPase mediated signal transduction!0.0356450410141685!10276$GO:0032989!cellular structure morphogenesis!0.0356450410141685!10276$GO:0000902!cell morphogenesis!0.0356450410141685!10276$GO:0030695!GTPase regulator activity!0.0489373601789709!10276
|id=C3026
}}

Latest revision as of 12:17, 17 September 2013


Full id: C3026_medulla_aorta_optic_spinal_locus_corpus_skeletal



Phase1 CAGE Peaks

Hg19::chr10:5454633..5454661,+p4@NET1
Hg19::chr10:5454672..5454689,+p1@CU690984
Hg19::chr4:79892654..79892672,+p5@LOC100505875


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0288031319910514
GO:0035023regulation of Rho protein signal transduction0.0288031319910514
GO:0001558regulation of cell growth0.0288031319910514
GO:0005088Ras guanyl-nucleotide exchange factor activity0.0288031319910514
GO:0007266Rho protein signal transduction0.0288031319910514
GO:0016049cell growth0.0288031319910514
GO:0040008regulation of growth0.0288031319910514
GO:0008361regulation of cell size0.0288031319910514
GO:0005085guanyl-nucleotide exchange factor activity0.0356450410141685
GO:0046578regulation of Ras protein signal transduction0.0356450410141685
GO:0007265Ras protein signal transduction0.0356450410141685
GO:0005083small GTPase regulator activity0.0356450410141685
GO:0051056regulation of small GTPase mediated signal transduction0.0356450410141685
GO:0032989cellular structure morphogenesis0.0356450410141685
GO:0000902cell morphogenesis0.0356450410141685
GO:0030695GTPase regulator activity0.0489373601789709



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism1.95e-58114
neural tube1.14e-3856
neural rod1.14e-3856
future spinal cord1.14e-3856
neural keel1.14e-3856
central nervous system4.77e-3881
regional part of nervous system9.74e-3653
regional part of brain9.74e-3653
nervous system3.00e-3489
brain7.85e-3368
future brain7.85e-3368
neural plate5.27e-3082
presumptive neural plate5.27e-3082
organ system subdivision1.04e-29223
neurectoderm2.87e-2986
regional part of forebrain3.90e-2941
forebrain3.90e-2941
anterior neural tube3.90e-2941
future forebrain3.90e-2941
ectoderm-derived structure1.70e-26171
ectoderm1.70e-26171
presumptive ectoderm1.70e-26171
ecto-epithelium2.14e-25104
brain grey matter1.83e-2434
gray matter1.83e-2434
telencephalon3.51e-2434
regional part of telencephalon1.54e-2232
structure with developmental contribution from neural crest1.83e-22132
cerebral hemisphere2.84e-2232
pre-chordal neural plate1.39e-1961
anatomical cluster4.17e-18373
cerebral cortex2.87e-1725
pallium2.87e-1725
regional part of cerebral cortex8.35e-1622
multi-tissue structure3.76e-14342
neocortex3.92e-1420
anatomical conduit6.15e-12240
posterior neural tube1.70e-1015
chordal neural plate1.70e-1015
tube2.25e-10192
organ2.59e-09503
segmental subdivision of nervous system9.76e-0913
neural nucleus1.01e-089
nucleus of brain1.01e-089
basal ganglion5.68e-089
nuclear complex of neuraxis5.68e-089
aggregate regional part of brain5.68e-089
collection of basal ganglia5.68e-089
cerebral subcortex5.68e-089
segmental subdivision of hindbrain8.51e-0812
hindbrain8.51e-0812
presumptive hindbrain8.51e-0812
brainstem1.85e-076
epithelium5.71e-07306
telencephalic nucleus8.53e-077


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.12.16573
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.11.36698
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.11.66081
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.11.37817
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.481578
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
NFYA#4800212.28372046655370.008516011403724430.0324611743126966
NFYB#4801211.17319550235760.01025467135054530.038109369860143
NR3C1#290829.982015554115360.01278474365547170.0460073682941841
SP2#6668217.43568699589640.004273568481769740.0203060609038922



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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