MCL coexpression mm9:287: Difference between revisions
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{{MCL_coexpression_mm9| | 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transport;0.000487893433099392;243616,14664,140919!GO:0005283;sodium:amino acid symporter activity;0.000487893433099392;243616,14664!GO:0005342;organic acid transmembrane transporter activity;0.000487893433099392;243616,14664,140919!GO:0005416;cation:amino acid symporter activity;0.000793169376948295;243616,14664!GO:0005328;neurotransmitter:sodium symporter activity;0.00238250463219786;243616,14664!GO:0005343;organic acid:sodium symporter activity;0.00238250463219786;243616,14664!GO:0005326;neurotransmitter transporter activity;0.00238250463219786;243616,14664!GO:0015179;L-amino acid transmembrane transporter activity;0.00277289081461163;243616,140919!GO:0005275;amine transmembrane transporter activity;0.00544349046617558;243616,14664!GO:0015171;amino acid transmembrane transporter activity;0.00549769167310049;243616,140919!GO:0015370;solute:sodium symporter activity;0.00617884339273634;243616,14664!GO:0015294;solute:cation symporter activity;0.0095865853648283;243616,14664!GO:0046943;carboxylic acid transmembrane transporter activity;0.00977373582424807;243616,140919!GO:0006581;acetylcholine catabolic process;0.00977373582424807;11423!GO:0003990;acetylcholinesterase activity;0.00977373582424807;11423!GO:0022891;substrate-specific transmembrane transporter activity;0.0124562618492223;243616,14664,70357,140919!GO:0008291;acetylcholine metabolic process;0.0154275641646028;11423!GO:0032800;receptor biosynthetic process;0.0154275641646028;11423!GO:0045212;neurotransmitter receptor biosynthetic process;0.0154275641646028;11423!GO:0001505;regulation of neurotransmitter levels;0.0163882840827892;11423,140919!GO:0022857;transmembrane transporter activity;0.016420888300229;243616,14664,70357,140919!GO:0006810;transport;0.0169058882193297;72661,243616,14664,70357,11423,140919!GO:0051234;establishment of localization;0.0169058882193297;72661,243616,14664,70357,11423,140919!GO:0001919;regulation of receptor recycling;0.0169058882193297;11423!GO:0043236;laminin binding;0.0169058882193297;11423!GO:0005332;gamma-aminobutyric acid:sodium symporter activity;0.0169058882193297;243616!GO:0022892;substrate-specific transporter activity;0.0178922045850977;243616,14664,70357,140919!GO:0031623;receptor internalization;0.0188998132089217;11423!GO:0004104;cholinesterase activity;0.0188998132089217;11423!GO:0042439;ethanolamine and derivative metabolic process;0.0188998132089217;11423!GO:0015185;L-gamma-aminobutyric acid transmembrane transporter activity;0.0188998132089217;243616!GO:0008324;cation transmembrane transporter activity;0.0200721206149368;243616,14664,70357!GO:0001881;receptor recycling;0.0217456361305597;11423!GO:0015293;symporter activity;0.0217456361305597;243616,14664!GO:0051179;localization;0.0219577964512983;72661,243616,14664,70357,11423,140919!GO:0050840;extracellular matrix binding;0.0219577964512983;11423!GO:0043621;protein self-association;0.0219577964512983;11423!GO:0045213;neurotransmitter receptor metabolic process;0.0219577964512983;11423!GO:0005313;L-glutamate transmembrane transporter activity;0.0219577964512983;140919!GO:0015172;acidic amino acid transmembrane transporter activity;0.0219577964512983;140919!GO:0001504;neurotransmitter uptake;0.0249850850611956;140919!GO:0051262;protein tetramerization;0.0278661202732491;11423!GO:0015291;secondary active transmembrane transporter activity;0.0296954910337121;243616,14664!GO:0060041;retina development in camera-type eye;0.0299153999596034;11423!GO:0042135;neurotransmitter catabolic process;0.0321993161904013;11423!GO:0007268;synaptic transmission;0.0321993161904013;11423,140919!GO:0015075;ion transmembrane transporter activity;0.0323653279984625;243616,14664,70357!GO:0004407;histone deacetylase activity;0.0357847268869069;232232!GO:0033558;protein deacetylase activity;0.0357847268869069;232232!GO:0019213;deacetylase activity;0.0394701876471836;232232!GO:0042402;biogenic amine catabolic process;0.0394701876471836;11423!GO:0019226;transmission of nerve impulse;0.0394701876471836;11423,140919!GO:0042219;amino acid derivative catabolic process;0.0432429813478802;11423!GO:0006898;receptor-mediated endocytosis;0.0432429813478802;11423!|ontology_enrichment_celltype=CL:0000117!2.16e-22!23;CL:0000337!2.16e-22!23;CL:0000540!1.62e-13!33;CL:0000047!1.62e-13!33;CL:0000031!1.62e-13!33;CL:0000404!1.62e-13!33;CL:0000393!1.93e-10!39;CL:0000211!1.93e-10!39;CL:0002319!6.85e-09!43;CL:0000221!1.50e-08!44;CL:0000133!1.50e-08!44;CL:0000055!4.47e-07!49|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0000073!2.49e-39!54;UBERON:0001049!1.98e-36!52;UBERON:0005068!1.98e-36!52;UBERON:0006241!1.98e-36!52;UBERON:0007135!1.98e-36!52;UBERON:0002346!9.42e-35!64;UBERON:0003075!9.42e-35!64;UBERON:0007284!9.42e-35!64;UBERON:0001017!5.03e-34!73;UBERON:0001016!1.04e-32!75;UBERON:0000955!1.68e-29!47;UBERON:0006238!1.68e-29!47;UBERON:0002020!6.16e-29!34;UBERON:0010371!1.12e-28!73;UBERON:0004121!1.20e-28!95;UBERON:0000924!1.20e-28!95;UBERON:0006601!1.20e-28!95;UBERON:0002616!2.65e-28!46;UBERON:0003056!2.97e-26!49;UBERON:0003080!1.49e-25!40;UBERON:0002780!2.63e-24!39;UBERON:0001890!2.63e-24!39;UBERON:0006240!2.63e-24!39;UBERON:0003528!3.72e-22!29;UBERON:0002791!3.72e-22!29;UBERON:0001893!3.72e-22!29;UBERON:0010314!8.15e-20!92;UBERON:0000956!3.34e-13!21;UBERON:0001869!3.34e-13!21;UBERON:0000203!3.34e-13!21;UBERON:0002021!5.37e-12!10;UBERON:0000411!5.37e-12!10;UBERON:0001950!5.37e-12!10;UBERON:0002619!9.00e-12!17;UBERON:0003076!5.22e-11!12;UBERON:0003057!5.22e-11!12;UBERON:0002420!1.18e-10!8;UBERON:0007245!1.18e-10!8;UBERON:0010009!1.18e-10!8;UBERON:0010011!1.18e-10!8;UBERON:0000454!1.18e-10!8;UBERON:0000025!1.09e-09!114;UBERON:0002240!1.72e-09!6;UBERON:0005174!1.72e-09!6;UBERON:0001137!1.72e-09!6;UBERON:0004111!2.66e-08!122;UBERON:0001948!2.84e-08!5;UBERON:0002315!2.84e-08!5;UBERON:0002950!7.59e-07!4;UBERON:0001891!7.59e-07!4;UBERON:0009616!7.59e-07!4;UBERON:0010286!7.59e-07!4|tfbs_overrepresentation_for_novel_motifs=0.536504,1.88777,0.220186,0.305194,0.105881,0.324459,0.148388,0.423532,0.0456397,0.471978,0.38953,0.435892,0.242781,0.472235,0.288144,0,0.288299,0.462025,0.0982406,0.383901,0.0473293,0.0693426,0.155233,0.0244851,0.229078,0.514394,1.10643,0.353106,0.14763,0.377483,0.101869,0.367297,0.738145,0.157123,0.289024,0.018278,0.225428,0.430558,0.0159813,0.300831,0.102492,0.340818,0.442687,0.122302,0.723503,0.290621,0.230231,0.117576,0.64161,0.625994,0.27523,0.190239,0.208624,0.485586,0.500658,0.483088,0.159565,0.417144,0.00461258,0.479984,0.351242,0.571459,0.496788,0.266898,0.167068,0.80545,0.621417,0.947606,0.347523,0.807939,0.439167,0.443501,1.53861,0.529888,1.31388,0.657384,0.696947,0.632797,0.337634,0.0488158,0.0443708,0.815104,0.195512,0.107931,0.430864,3.31044,1.91667,0.015138,0.233678,1.10402,0.684894,0.435043,0.984712,0.501015,0.36203,0.0592604,0.415328,0.989725,0.23041,0.464797,0.0203943,0.367072,0.470627,0.275672,0.274889,0.10429,0.857465,0.115402,0.188807,0.716259,0.52086,0.472153,0.413098,0.791911,0.691366,0.101001,0.861133,1.5806,0.28928,0.219349,0.534627,0.251614,0.174046,0.631319,0.741383,0.340552,0.153289,0.972632,0.620047,0.509539,0.456151,0.295631,1.4474,0.503994,0.711262,0.900678,0.0756323,0.105244,0.6661,1.46501,1.07314,0.625675,0.181758,0.375761,0.270089,0.104751,0.656561,1.42588,0.0766814,0.261542,0.387255,2.59374,0.486938,0.559278,1.54465,0.558342,0.1909,0.567187,0.531033,0.941491,0.674799,0.430147,0.340904,0.515877,0.738132,0.163443,0.697175,0.140344,0.672203|tfbs_overrepresentation_jaspar=MA0003.1;3.43156,MA0004.1;0.305832,MA0006.1;1.20095,MA0007.1;0.084375,MA0009.1;0.388771,MA0014.1;3.08692,MA0017.1;0.141194,MA0019.1;0.248074,MA0024.1;0.353393,MA0025.1;1.43891,MA0027.1;1.95996,MA0028.1;0.12595,MA0029.1;0.336166,MA0030.1;0.341346,MA0031.1;0.84229,MA0038.1;0.17284,MA0040.1;0.399043,MA0041.1;0.464369,MA0042.1;0.0533455,MA0043.1;0.469769,MA0046.1;0.418434,MA0048.1;0.67799,MA0050.1;0.111159,MA0051.1;0.178537,MA0052.1;0.405693,MA0055.1;0.378635,MA0056.1;0,MA0057.1;0.830691,MA0058.1;0.189695,MA0059.1;0.203408,MA0060.1;0.0114726,MA0061.1;0.380864,MA0063.1;0,MA0066.1;0.165937,MA0067.1;0.690195,MA0068.1;2.96294,MA0069.1;0.405974,MA0070.1;0.397975,MA0071.1;0.357212,MA0072.1;0.391015,MA0073.1;2.55311,MA0074.1;0.443199,MA0076.1;0.0413193,MA0077.1;0.373365,MA0078.1;0.200156,MA0081.1;0.0645216,MA0083.1;1.18326,MA0084.1;0.999346,MA0087.1;0.432564,MA0088.1;1.80197,MA0089.1;0,MA0090.1;0.942377,MA0091.1;0.32331,MA0092.1;0.555994,MA0093.1;0.314468,MA0095.1;0,MA0098.1;0,MA0100.1;0.137416,MA0101.1;0.0588523,MA0103.1;0.350053,MA0105.1;0.672153,MA0106.1;0.592733,MA0107.1;0.338168,MA0108.2;0.264668,MA0109.1;0,MA0111.1;0.27977,MA0113.1;0.186674,MA0114.1;0.0743624,MA0115.1;0.472164,MA0116.1;0.279815,MA0117.1;0.44472,MA0119.1;0.059082,MA0122.1;0.461557,MA0124.1;0.641584,MA0125.1;0.574947,MA0130.1;0,MA0131.1;0.685442,MA0132.1;0,MA0133.1;0,MA0135.1;0.501131,MA0136.1;0.156089,MA0139.1;0.92028,MA0140.1;0.13735,MA0141.1;1.06715,MA0142.1;0.817195,MA0143.1;0.573785,MA0144.1;0.0765684,MA0145.1;0.087554,MA0146.1;0.392056,MA0147.1;1.00524,MA0148.1;0.327464,MA0149.1;0.220008,MA0062.2;0.00387198,MA0035.2;0.432878,MA0039.2;0.224742,MA0138.2;2.716,MA0002.2;0.114411,MA0137.2;0.0441189,MA0104.2;1.3763,MA0047.2;0.987855,MA0112.2;1.31116,MA0065.2;0.273313,MA0150.1;0.286158,MA0151.1;0,MA0152.1;0.172422,MA0153.1;0.515592,MA0154.1;0.459593,MA0155.1;1.1957,MA0156.1;0.0410387,MA0157.1;0.762276,MA0158.1;0,MA0159.1;1.05755,MA0160.1;0.331527,MA0161.1;0,MA0162.1;0.824796,MA0163.1;1.34258,MA0164.1;0.15631,MA0080.2;0.146586,MA0018.2;0.488272,MA0099.2;0.234689,MA0079.2;2.90175,MA0102.2;1.04989,MA0258.1;0.570617,MA0259.1;0.386929,MA0442.1;0}} |
Latest revision as of 15:02, 17 September 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006836 | neurotransmitter transport | 0.000487893433099392 |
GO:0005283 | sodium:amino acid symporter activity | 0.000487893433099392 |
GO:0005342 | organic acid transmembrane transporter activity | 0.000487893433099392 |
GO:0005416 | cation:amino acid symporter activity | 0.000793169376948295 |
GO:0005328 | neurotransmitter:sodium symporter activity | 0.00238250463219786 |
GO:0005343 | organic acid:sodium symporter activity | 0.00238250463219786 |
GO:0005326 | neurotransmitter transporter activity | 0.00238250463219786 |
GO:0015179 | L-amino acid transmembrane transporter activity | 0.00277289081461163 |
GO:0005275 | amine transmembrane transporter activity | 0.00544349046617558 |
GO:0015171 | amino acid transmembrane transporter activity | 0.00549769167310049 |
GO:0015370 | solute:sodium symporter activity | 0.00617884339273634 |
GO:0015294 | solute:cation symporter activity | 0.0095865853648283 |
GO:0046943 | carboxylic acid transmembrane transporter activity | 0.00977373582424807 |
GO:0006581 | acetylcholine catabolic process | 0.00977373582424807 |
GO:0003990 | acetylcholinesterase activity | 0.00977373582424807 |
GO:0022891 | substrate-specific transmembrane transporter activity | 0.0124562618492223 |
GO:0008291 | acetylcholine metabolic process | 0.0154275641646028 |
GO:0032800 | receptor biosynthetic process | 0.0154275641646028 |
GO:0045212 | neurotransmitter receptor biosynthetic process | 0.0154275641646028 |
GO:0001505 | regulation of neurotransmitter levels | 0.0163882840827892 |
GO:0022857 | transmembrane transporter activity | 0.016420888300229 |
GO:0006810 | transport | 0.0169058882193297 |
GO:0051234 | establishment of localization | 0.0169058882193297 |
GO:0001919 | regulation of receptor recycling | 0.0169058882193297 |
GO:0043236 | laminin binding | 0.0169058882193297 |
GO:0005332 | gamma-aminobutyric acid:sodium symporter activity | 0.0169058882193297 |
GO:0022892 | substrate-specific transporter activity | 0.0178922045850977 |
GO:0031623 | receptor internalization | 0.0188998132089217 |
GO:0004104 | cholinesterase activity | 0.0188998132089217 |
GO:0042439 | ethanolamine and derivative metabolic process | 0.0188998132089217 |
GO:0015185 | L-gamma-aminobutyric acid transmembrane transporter activity | 0.0188998132089217 |
GO:0008324 | cation transmembrane transporter activity | 0.0200721206149368 |
GO:0001881 | receptor recycling | 0.0217456361305597 |
GO:0015293 | symporter activity | 0.0217456361305597 |
GO:0051179 | localization | 0.0219577964512983 |
GO:0050840 | extracellular matrix binding | 0.0219577964512983 |
GO:0043621 | protein self-association | 0.0219577964512983 |
GO:0045213 | neurotransmitter receptor metabolic process | 0.0219577964512983 |
GO:0005313 | L-glutamate transmembrane transporter activity | 0.0219577964512983 |
GO:0015172 | acidic amino acid transmembrane transporter activity | 0.0219577964512983 |
GO:0001504 | neurotransmitter uptake | 0.0249850850611956 |
GO:0051262 | protein tetramerization | 0.0278661202732491 |
GO:0015291 | secondary active transmembrane transporter activity | 0.0296954910337121 |
GO:0060041 | retina development in camera-type eye | 0.0299153999596034 |
GO:0042135 | neurotransmitter catabolic process | 0.0321993161904013 |
GO:0007268 | synaptic transmission | 0.0321993161904013 |
GO:0015075 | ion transmembrane transporter activity | 0.0323653279984625 |
GO:0004407 | histone deacetylase activity | 0.0357847268869069 |
GO:0033558 | protein deacetylase activity | 0.0357847268869069 |
GO:0019213 | deacetylase activity | 0.0394701876471836 |
GO:0042402 | biogenic amine catabolic process | 0.0394701876471836 |
GO:0019226 | transmission of nerve impulse | 0.0394701876471836 |
GO:0042219 | amino acid derivative catabolic process | 0.0432429813478802 |
GO:0006898 | receptor-mediated endocytosis | 0.0432429813478802 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
CNS neuron (sensu Vertebrata) | 2.16e-22 | 23 |
neuroblast (sensu Vertebrata) | 2.16e-22 | 23 |
neuron | 1.62e-13 | 33 |
neuronal stem cell | 1.62e-13 | 33 |
neuroblast | 1.62e-13 | 33 |
electrically signaling cell | 1.62e-13 | 33 |
electrically responsive cell | 1.93e-10 | 39 |
electrically active cell | 1.93e-10 | 39 |
neural cell | 6.85e-09 | 43 |
ectodermal cell | 1.50e-08 | 44 |
neurectodermal cell | 1.50e-08 | 44 |
non-terminally differentiated cell | 4.47e-07 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 3.43156 |
MA0004.1 | 0.305832 |
MA0006.1 | 1.20095 |
MA0007.1 | 0.084375 |
MA0009.1 | 0.388771 |
MA0014.1 | 3.08692 |
MA0017.1 | 0.141194 |
MA0019.1 | 0.248074 |
MA0024.1 | 0.353393 |
MA0025.1 | 1.43891 |
MA0027.1 | 1.95996 |
MA0028.1 | 0.12595 |
MA0029.1 | 0.336166 |
MA0030.1 | 0.341346 |
MA0031.1 | 0.84229 |
MA0038.1 | 0.17284 |
MA0040.1 | 0.399043 |
MA0041.1 | 0.464369 |
MA0042.1 | 0.0533455 |
MA0043.1 | 0.469769 |
MA0046.1 | 0.418434 |
MA0048.1 | 0.67799 |
MA0050.1 | 0.111159 |
MA0051.1 | 0.178537 |
MA0052.1 | 0.405693 |
MA0055.1 | 0.378635 |
MA0056.1 | 0 |
MA0057.1 | 0.830691 |
MA0058.1 | 0.189695 |
MA0059.1 | 0.203408 |
MA0060.1 | 0.0114726 |
MA0061.1 | 0.380864 |
MA0063.1 | 0 |
MA0066.1 | 0.165937 |
MA0067.1 | 0.690195 |
MA0068.1 | 2.96294 |
MA0069.1 | 0.405974 |
MA0070.1 | 0.397975 |
MA0071.1 | 0.357212 |
MA0072.1 | 0.391015 |
MA0073.1 | 2.55311 |
MA0074.1 | 0.443199 |
MA0076.1 | 0.0413193 |
MA0077.1 | 0.373365 |
MA0078.1 | 0.200156 |
MA0081.1 | 0.0645216 |
MA0083.1 | 1.18326 |
MA0084.1 | 0.999346 |
MA0087.1 | 0.432564 |
MA0088.1 | 1.80197 |
MA0089.1 | 0 |
MA0090.1 | 0.942377 |
MA0091.1 | 0.32331 |
MA0092.1 | 0.555994 |
MA0093.1 | 0.314468 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.137416 |
MA0101.1 | 0.0588523 |
MA0103.1 | 0.350053 |
MA0105.1 | 0.672153 |
MA0106.1 | 0.592733 |
MA0107.1 | 0.338168 |
MA0108.2 | 0.264668 |
MA0109.1 | 0 |
MA0111.1 | 0.27977 |
MA0113.1 | 0.186674 |
MA0114.1 | 0.0743624 |
MA0115.1 | 0.472164 |
MA0116.1 | 0.279815 |
MA0117.1 | 0.44472 |
MA0119.1 | 0.059082 |
MA0122.1 | 0.461557 |
MA0124.1 | 0.641584 |
MA0125.1 | 0.574947 |
MA0130.1 | 0 |
MA0131.1 | 0.685442 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.501131 |
MA0136.1 | 0.156089 |
MA0139.1 | 0.92028 |
MA0140.1 | 0.13735 |
MA0141.1 | 1.06715 |
MA0142.1 | 0.817195 |
MA0143.1 | 0.573785 |
MA0144.1 | 0.0765684 |
MA0145.1 | 0.087554 |
MA0146.1 | 0.392056 |
MA0147.1 | 1.00524 |
MA0148.1 | 0.327464 |
MA0149.1 | 0.220008 |
MA0062.2 | 0.00387198 |
MA0035.2 | 0.432878 |
MA0039.2 | 0.224742 |
MA0138.2 | 2.716 |
MA0002.2 | 0.114411 |
MA0137.2 | 0.0441189 |
MA0104.2 | 1.3763 |
MA0047.2 | 0.987855 |
MA0112.2 | 1.31116 |
MA0065.2 | 0.273313 |
MA0150.1 | 0.286158 |
MA0151.1 | 0 |
MA0152.1 | 0.172422 |
MA0153.1 | 0.515592 |
MA0154.1 | 0.459593 |
MA0155.1 | 1.1957 |
MA0156.1 | 0.0410387 |
MA0157.1 | 0.762276 |
MA0158.1 | 0 |
MA0159.1 | 1.05755 |
MA0160.1 | 0.331527 |
MA0161.1 | 0 |
MA0162.1 | 0.824796 |
MA0163.1 | 1.34258 |
MA0164.1 | 0.15631 |
MA0080.2 | 0.146586 |
MA0018.2 | 0.488272 |
MA0099.2 | 0.234689 |
MA0079.2 | 2.90175 |
MA0102.2 | 1.04989 |
MA0258.1 | 0.570617 |
MA0259.1 | 0.386929 |
MA0442.1 | 0 |