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{{Coexpression_clusters
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|full_id=C2393_Melanocyte_pons_occipital_postcentral_parietal_paracentral_medulla
|id=C2393
|ontology_enrichment_celltype=CL:0000055!2.37e-08!180
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!1.61e-35!115;UBERON:0001049!1.54e-28!57;UBERON:0005068!1.54e-28!57;UBERON:0006241!1.54e-28!57;UBERON:0007135!1.54e-28!57;UBERON:0005743!6.83e-28!86;UBERON:0003075!9.04e-28!86;UBERON:0007284!9.04e-28!86;UBERON:0002616!9.64e-27!59;UBERON:0000073!1.50e-25!94;UBERON:0001016!1.50e-25!94;UBERON:0002346!1.82e-25!90;UBERON:0001017!2.59e-25!82;UBERON:0000955!8.08e-25!69;UBERON:0006238!8.08e-25!69;UBERON:0003080!3.75e-20!42;UBERON:0002780!1.18e-19!41;UBERON:0001890!1.18e-19!41;UBERON:0006240!1.18e-19!41;UBERON:0000033!1.21e-19!123;UBERON:0003056!2.73e-19!61;UBERON:0000153!1.71e-18!129;UBERON:0007811!1.71e-18!129;UBERON:0002020!4.46e-18!34;UBERON:0003528!4.46e-18!34;UBERON:0001893!4.78e-18!34;UBERON:0002791!2.68e-17!33;UBERON:0001869!6.78e-17!32;UBERON:0004121!5.50e-16!169;UBERON:0000924!5.30e-15!173;UBERON:0006601!5.30e-15!173;UBERON:0002619!3.34e-13!22;UBERON:0000475!4.94e-13!365;UBERON:0000956!1.59e-12!25;UBERON:0000203!1.59e-12!25;UBERON:0001950!5.39e-12!20;UBERON:0003076!1.46e-09!15;UBERON:0003057!1.46e-09!15;UBERON:0000025!2.15e-09!194;UBERON:0000119!3.07e-09!312;UBERON:0000062!9.19e-09!511;UBERON:0000483!1.13e-08!309;UBERON:0000477!2.60e-08!286;UBERON:0004111!3.44e-08!241;UBERON:0000468!4.12e-08!659;UBERON:0004732!7.02e-08!13;UBERON:0004733!1.39e-07!12;UBERON:0002028!1.39e-07!12;UBERON:0007277!1.39e-07!12;UBERON:0000481!2.00e-07!347;UBERON:0002308!3.71e-07!9;UBERON:0000125!3.71e-07!9;UBERON:0000467!3.98e-07!625;UBERON:0000480!5.45e-07!626;UBERON:0002420!6.84e-07!9;UBERON:0007245!6.84e-07!9;UBERON:0010009!6.84e-07!9;UBERON:0010011!6.84e-07!9;UBERON:0000454!6.84e-07!9
}}

Latest revision as of 12:04, 17 September 2013


Full id: C2393_Melanocyte_pons_occipital_postcentral_parietal_paracentral_medulla



Phase1 CAGE Peaks

Hg19::chr17:1090536..1090553,-p13@ABR
Hg19::chr17:1090557..1090580,-p7@ABR
Hg19::chr17:1090599..1090620,-p11@ABR
Hg19::chr17:1090622..1090652,-p12@ABR


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
pigment cell7.51e-0914
melanocyte2.05e-0710
melanoblast2.05e-0710
Uber Anatomy
Ontology termp-valuen
adult organism2.08e-39114
neural tube2.86e-3056
neural rod2.86e-3056
future spinal cord2.86e-3056
neural keel2.86e-3056
neural plate1.50e-2882
presumptive neural plate1.50e-2882
regional part of nervous system8.99e-2853
regional part of brain8.99e-2853
central nervous system1.75e-2681
neurectoderm4.27e-2686
brain1.10e-2568
future brain1.10e-2568
structure with developmental contribution from neural crest4.45e-22132
regional part of forebrain6.96e-2241
forebrain6.96e-2241
anterior neural tube6.96e-2241
future forebrain6.96e-2241
nervous system1.37e-2189
ecto-epithelium2.74e-21104
pre-chordal neural plate2.51e-2061
telencephalon4.65e-2034
brain grey matter4.69e-2034
gray matter4.69e-2034
cerebral hemisphere8.72e-1932
regional part of telencephalon2.57e-1832
ectoderm-derived structure6.36e-15171
ectoderm6.36e-15171
presumptive ectoderm6.36e-15171
regional part of cerebral cortex1.61e-1322
cerebral cortex2.60e-1325
pallium2.60e-1325
neocortex3.88e-1220
posterior neural tube1.71e-0915
chordal neural plate1.71e-0915
neural nucleus1.72e-089
nucleus of brain1.72e-089
anatomical cluster9.11e-08373
organ system subdivision9.59e-08223
multi-tissue structure9.85e-08342
tube1.13e-07192
cell layer2.52e-07309
organ2.56e-07503
gyrus3.49e-076
multi-cellular organism3.73e-07656
segmental subdivision of hindbrain4.06e-0712
hindbrain4.06e-0712
presumptive hindbrain4.06e-0712
brainstem5.10e-076
anatomical conduit5.87e-07240
epithelium6.11e-07306


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.12.02223
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.11.70187
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.14.42006
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.01976
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.17.78226
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.70272
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.23.52208
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.577908
MA0150.11.53138
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774421.65264761012184.54636978835329e-060.000141525578040486
CTCF#1066445.360256373075030.001211145381643620.00816860268088333
PAX5#507946.669565531177830.0005052774169483260.00443637395112788
RAD21#5885410.35503389545638.6948481184721e-050.00129301045514041
SMC3#9126415.04493284493281.95092670935632e-050.000437613476371273
TAF1#687243.343046285745290.008005664898701650.032192501014766
YY1#752844.911170749853860.00171871838055440.0106757005439944
ZNF143#7702413.50087655222793.00867915035614e-050.000620381918625952
ZNF263#1012748.221841637010680.0002187871180958320.00248638822925034



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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