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Coexpression cluster:C2350: Difference between revisions

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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 12:03, 17 September 2013


Full id: C2350_medial_brain_amygdala_hippocampus_neuroectodermal_occipital_small



Phase1 CAGE Peaks

Hg19::chr15:77907614..77907624,-p17@LINGO1
Hg19::chr15:77907723..77907735,-p13@LINGO1
Hg19::chr19:42486186..42486199,-p6@ATP1A3
Hg19::chr6:110448757..110448782,-p9@WASF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0035235ionotropic glutamate receptor signaling pathway0.0147744428218659
GO:0006928cell motility0.0147744428218659
GO:0051674localization of cell0.0147744428218659
GO:0008542visual learning0.0147744428218659
GO:0005890sodium:potassium-exchanging ATPase complex0.0147744428218659
GO:0007632visual behavior0.0147744428218659
GO:0007613memory0.0147744428218659
GO:0030641cellular hydrogen ion homeostasis0.0147744428218659
GO:0008344adult locomotory behavior0.0147744428218659
GO:0030004cellular monovalent inorganic cation homeostasis0.0147744428218659
GO:0055067monovalent inorganic cation homeostasis0.0147744428218659
GO:0005391sodium:potassium-exchanging ATPase activity0.0147744428218659
GO:0007612learning0.0147744428218659
GO:0030317sperm motility0.0158154819779361
GO:0007215glutamate signaling pathway0.0158154819779361
GO:0030534adult behavior0.0190599366900479
GO:0030041actin filament polymerization0.0205939328850991
GO:0007611learning and/or memory0.0275956377504917
GO:0008154actin polymerization and/or depolymerization0.0355408482650936
GO:0042493response to drug0.0355408482650936
GO:0009416response to light stimulus0.0434963365107109
GO:0031402sodium ion binding0.0474286948824892
GO:0051258protein polymerization0.0474286948824892
GO:0009314response to radiation0.0474286948824892



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
neuron1.22e-116
neuroblast1.22e-116
electrically signaling cell1.22e-116
neuronal stem cell2.92e-118
neurectodermal cell7.99e-1059
embryonic stem cell4.55e-095
ectodermal cell4.03e-0772
Uber Anatomy
Ontology termp-valuen
nervous system1.59e-6189
central nervous system1.05e-5781
regional part of nervous system1.11e-4753
regional part of brain1.11e-4753
neural tube2.48e-4756
neural rod2.48e-4756
future spinal cord2.48e-4756
neural keel2.48e-4756
brain4.39e-4568
future brain4.39e-4568
regional part of forebrain8.72e-4341
forebrain8.72e-4341
anterior neural tube8.72e-4341
future forebrain8.72e-4341
cerebral hemisphere3.47e-4032
telencephalon3.99e-4034
brain grey matter5.80e-4034
gray matter5.80e-4034
neurectoderm4.50e-3986
regional part of telencephalon5.99e-3732
ectoderm-derived structure6.18e-37171
ectoderm6.18e-37171
presumptive ectoderm6.18e-37171
regional part of cerebral cortex6.83e-3722
neural plate1.58e-3382
presumptive neural plate1.58e-3382
neocortex3.92e-3320
cerebral cortex7.95e-3225
pallium7.95e-3225
pre-chordal neural plate3.27e-2961
ecto-epithelium5.33e-28104
adult organism1.35e-26114
organ system subdivision1.43e-21223
structure with developmental contribution from neural crest2.85e-19132
gyrus4.70e-136
temporal lobe2.64e-116
limbic system5.87e-115
parietal lobe1.09e-105
basal ganglion2.98e-109
nuclear complex of neuraxis2.98e-109
aggregate regional part of brain2.98e-109
collection of basal ganglia2.98e-109
cerebral subcortex2.98e-109
anatomical cluster4.55e-10373
neural nucleus1.43e-099
nucleus of brain1.43e-099
sympathetic nervous system3.73e-095
autonomic nervous system3.73e-095
tube9.75e-09192
brainstem1.47e-076
frontal cortex2.77e-073
occipital lobe3.25e-075
posterior neural tube5.05e-0715
chordal neural plate5.05e-0715
segmental subdivision of hindbrain7.55e-0712
hindbrain7.55e-0712
presumptive hindbrain7.55e-0712
telencephalic nucleus8.91e-077
Disease
Ontology termp-valuen
neuroectodermal tumor2.33e-1410
neuroendocrine tumor1.47e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.13.06856
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.11.9583
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0021048
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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