Coexpression cluster:C1760

Full id: C1760_brain_occipital_temporal_duodenum_parietal_medulloblastoma_myeloma

Phase1 CAGE Peaks

Hg19::chr16:28303874..28303916,+	p2@SBK1
Hg19::chr1:200992739..200992763,-	p3@KIF21B
Hg19::chr1:200992771..200992815,-	p1@KIF21B
Hg19::chr1:200992827..200992867,-	p2@KIF21B
Hg19::chr3:111393542..111393579,+	p1@PLCXD2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	4.70e-31	177
hematopoietic stem cell	2.41e-30	168
angioblastic mesenchymal cell	2.41e-30	168
hematopoietic oligopotent progenitor cell	2.74e-28	161
hematopoietic multipotent progenitor cell	2.74e-28	161
leukocyte	2.72e-24	136
nongranular leukocyte	8.38e-23	115
lymphocyte	1.15e-22	53
common lymphoid progenitor	1.15e-22	53
lymphoid lineage restricted progenitor cell	2.02e-22	52
nucleate cell	1.99e-21	55
hematopoietic lineage restricted progenitor cell	5.48e-19	120
T cell	3.63e-14	25
pro-T cell	3.63e-14	25
mature alpha-beta T cell	2.68e-11	18
alpha-beta T cell	2.68e-11	18
immature T cell	2.68e-11	18
mature T cell	2.68e-11	18
immature alpha-beta T cell	2.68e-11	18
myeloid cell	1.99e-09	108
common myeloid progenitor	1.99e-09	108
CD8-positive, alpha-beta T cell	5.46e-08	11
lymphocyte of B lineage	5.51e-08	24
pro-B cell	5.51e-08	24

Uber Anatomy

Ontology term	p-value	n
central nervous system	1.10e-17	81
neural tube	8.55e-17	56
neural rod	8.55e-17	56
future spinal cord	8.55e-17	56
neural keel	8.55e-17	56
adult organism	7.92e-16	114
regional part of nervous system	8.18e-16	53
regional part of brain	8.18e-16	53
nervous system	1.39e-14	89
regional part of forebrain	8.11e-14	41
forebrain	8.11e-14	41
anterior neural tube	8.11e-14	41
future forebrain	8.11e-14	41
brain	1.88e-13	68
future brain	1.88e-13	68
telencephalon	6.58e-13	34
brain grey matter	7.43e-13	34
gray matter	7.43e-13	34
cerebral hemisphere	2.12e-12	32
regional part of cerebral cortex	2.12e-12	22
regional part of telencephalon	3.86e-12	32
neocortex	1.55e-11	20
cerebral cortex	8.05e-10	25
pallium	8.05e-10	25
blood	3.42e-09	15
haemolymphatic fluid	3.42e-09	15
organism substance	3.42e-09	15
neural plate	6.77e-09	82
presumptive neural plate	6.77e-09	82
pre-chordal neural plate	2.01e-08	61
neurectoderm	2.64e-08	86
hemolymphoid system	3.49e-08	108
hematopoietic system	5.17e-08	98
blood island	5.17e-08	98

Disease

Ontology term	p-value	n
hematologic cancer	1.00e-10	51
immune system cancer	1.00e-10	51
leukemia	3.83e-08	39

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	5	4.90738921487932	0.000351281809925646	0.00352696798181355
E2F6#1876	4	4.01372458535791	0.00663211823393388	0.0282934437414248
EGR1#1958	5	4.98817909481014	0.000323739800059071	0.00330702865594379
ETS1#2113	3	5.8372565533214	0.00925327904563143	0.0349715281988384
MYC#4609	4	4.17782549728752	0.00569196903682344	0.0256787712413306
SIN3A#25942	4	4.32710778145211	0.00497705285576288	0.0232436803292501
SRF#6722	3	8.27830695730069	0.00340484607377615	0.0173606756382906

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.