Coexpression cluster:C3841

Full id: C3841_cerebellum_skeletal_insula_paracentral_frontal_occipital_parietal

Phase1 CAGE Peaks

Hg19::chr1:10270644..10270651,+	p4@KIF1B
Hg19::chr1:53192114..53192150,+	p1@ZYG11B
Hg19::chr2:170683942..170683972,+	p1@UBR3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0008089	anterograde axon cargo transport	0.010993053729904
GO:0008088	axon cargo transport	0.010993053729904
GO:0019894	kinesin binding	0.010993053729904
GO:0007274	neuromuscular synaptic transmission	0.010993053729904
GO:0007270	nerve-nerve synaptic transmission	0.0185633133458944

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
adult organism	4.74e-45	114
neural tube	3.88e-28	56
neural rod	3.88e-28	56
future spinal cord	3.88e-28	56
neural keel	3.88e-28	56
central nervous system	9.75e-28	81
regional part of nervous system	1.87e-26	53
regional part of brain	1.87e-26	53
brain	1.87e-26	68
future brain	1.87e-26	68
nervous system	6.90e-26	89
regional part of forebrain	1.93e-25	41
forebrain	1.93e-25	41
anterior neural tube	1.93e-25	41
future forebrain	1.93e-25	41
telencephalon	1.51e-21	34
brain grey matter	1.84e-21	34
gray matter	1.84e-21	34
cerebral hemisphere	1.88e-20	32
regional part of telencephalon	2.46e-20	32
neural plate	1.08e-19	82
presumptive neural plate	1.08e-19	82
neurectoderm	2.39e-18	86
ectoderm-derived structure	2.59e-17	171
ectoderm	2.59e-17	171
presumptive ectoderm	2.59e-17	171
cerebral cortex	3.47e-16	25
pallium	3.47e-16	25
pre-chordal neural plate	8.26e-16	61
regional part of cerebral cortex	1.36e-15	22
organ system subdivision	6.72e-15	223
neocortex	2.05e-14	20
ecto-epithelium	2.50e-14	104
structure with developmental contribution from neural crest	5.91e-14	132
organ	1.76e-12	503
multi-cellular organism	5.80e-11	656
anatomical system	1.01e-09	624
anatomical group	1.32e-09	625
germ layer	4.05e-07	560
germ layer / neural crest	4.05e-07	560
embryonic tissue	4.05e-07	560
presumptive structure	4.05e-07	560
germ layer / neural crest derived structure	4.05e-07	560
epiblast (generic)	4.05e-07	560
embryonic structure	4.62e-07	564
basal ganglion	7.74e-07	9
nuclear complex of neuraxis	7.74e-07	9
aggregate regional part of brain	7.74e-07	9
collection of basal ganglia	7.74e-07	9
cerebral subcortex	7.74e-07	9
developing anatomical structure	9.57e-07	581
neural nucleus	9.91e-07	9
nucleus of brain	9.91e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0190057223604282
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0128098719105501
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0276799794488489
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0329428725223493

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.