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Coexpression cluster:C2215

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Full id: C2215_CD14CD16_CD4_CD8_CD19_CD14_Basophils_Whole



Phase1 CAGE Peaks

Hg19::chr12:53689319..53689349,+p1@PFDN5
Hg19::chr1:160681597..160681619,-p1@CD48
Hg19::chr6:29691170..29691188,+p2@HLA-F
Hg19::chr6:32811861..32811872,+p1@LOC100507463


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.44e-58140
hematopoietic stem cell1.72e-50172
angioblastic mesenchymal cell1.72e-50172
hematopoietic lineage restricted progenitor cell2.21e-50124
nongranular leukocyte7.12e-50119
hematopoietic oligopotent progenitor cell4.86e-47165
hematopoietic multipotent progenitor cell4.86e-47165
hematopoietic cell4.41e-46182
myeloid leukocyte8.52e-2776
lymphocyte1.65e-2553
common lymphoid progenitor1.65e-2553
lymphoid lineage restricted progenitor cell3.65e-2552
CD14-positive, CD16-negative classical monocyte4.86e-2442
myeloid lineage restricted progenitor cell1.54e-2370
granulocyte monocyte progenitor cell2.10e-2371
macrophage dendritic cell progenitor2.73e-2265
monopoietic cell8.03e-2263
monocyte8.03e-2263
monoblast8.03e-2263
promonocyte8.03e-2263
myeloid cell2.21e-21112
common myeloid progenitor2.21e-21112
classical monocyte2.39e-2045
T cell1.07e-1225
pro-T cell1.07e-1225
lymphocyte of B lineage2.49e-1224
pro-B cell2.49e-1224
mature alpha-beta T cell2.07e-1118
alpha-beta T cell2.07e-1118
immature T cell2.07e-1118
mature T cell2.07e-1118
immature alpha-beta T cell2.07e-1118
mesenchymal cell2.56e-11358
connective tissue cell1.72e-10365
B cell4.61e-0914
CD8-positive, alpha-beta T cell6.14e-0811
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.23e-30102
blood island3.23e-30102
hemolymphoid system5.83e-28112
bone marrow7.69e-2180
immune system1.37e-16115
bone element2.09e-1686
skeletal element2.36e-13101
skeletal system2.36e-13101
connective tissue9.70e-10375
adult organism5.43e-08115
blood1.15e-0715
haemolymphatic fluid1.15e-0715
organism substance1.15e-0715
lateral plate mesoderm2.77e-07216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.