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Coexpression cluster:C293

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Full id: C293_CD14_CD14CD16_Basophils_Peripheral_immature_Eosinophils_CD34



Phase1 CAGE Peaks

Hg19::chr10:104563028..104563065,-p@chr10:104563028..104563065
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Hg19::chr11:10921577..10921613,+p@chr11:10921577..10921613
+
Hg19::chr11:109898250..109898258,+p@chr11:109898250..109898258
+
Hg19::chr11:503682..503702,+p@chr11:503682..503702
+
Hg19::chr12:116996410..116996424,+p@chr12:116996410..116996424
+
Hg19::chr12:69004435..69004453,-p@chr12:69004435..69004453
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Hg19::chr13:41591558..41591570,+p@chr13:41591558..41591570
+
Hg19::chr15:67385901..67385913,-p@chr15:67385901..67385913
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Hg19::chr15:67402220..67402236,+p@chr15:67402220..67402236
+
Hg19::chr16:11892467..11892492,-p@chr16:11892467..11892492
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Hg19::chr17:7036438..7036444,+p@chr17:7036438..7036444
+
Hg19::chr17:79790192..79790220,+p@chr17:79790192..79790220
+
Hg19::chr17:81147275..81147285,-p@chr17:81147275..81147285
-
Hg19::chr17:81147409..81147425,-p@chr17:81147409..81147425
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Hg19::chr17:81148156..81148167,-p@chr17:81148156..81148167
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Hg19::chr17:8856790..8856815,+p@chr17:8856790..8856815
+
Hg19::chr1:234535009..234535013,+p@chr1:234535009..234535013
+
Hg19::chr1:236230397..236230414,+p@chr1:236230397..236230414
+
Hg19::chr1:27986166..27986179,-p@chr1:27986166..27986179
-
Hg19::chr1:42230480..42230491,+p@chr1:42230480..42230491
+
Hg19::chr22:44464675..44464690,-p@chr22:44464675..44464690
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Hg19::chr22:50743236..50743253,+p@chr22:50743236..50743253
+
Hg19::chr2:10169430..10169492,+p@chr2:10169430..10169492
+
Hg19::chr2:145273135..145273151,-p@chr2:145273135..145273151
-
Hg19::chr2:145440056..145440091,+p@chr2:145440056..145440091
+
Hg19::chr2:145440766..145440771,-p@chr2:145440766..145440771
-
Hg19::chr2:145441152..145441172,+p@chr2:145441152..145441172
+
Hg19::chr2:145441185..145441198,+p@chr2:145441185..145441198
+
Hg19::chr2:208366677..208366692,-p@chr2:208366677..208366692
-
Hg19::chr2:238603376..238603380,+p@chr2:238603376..238603380
+
Hg19::chr2:243028282..243028329,+p@chr2:243028282..243028329
+
Hg19::chr3:148863449..148863470,+p@chr3:148863449..148863470
+
Hg19::chr3:188118437..188118443,+p@chr3:188118437..188118443
+
Hg19::chr4:130015616..130015630,-p@chr4:130015616..130015630
-
Hg19::chr4:148604535..148604547,+p@chr4:148604535..148604547
+
Hg19::chr4:159731587..159731603,+p@chr4:159731587..159731603
+
Hg19::chr4:2788911..2788937,-p@chr4:2788911..2788937
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Hg19::chr4:3374939..3374950,+p@chr4:3374939..3374950
+
Hg19::chr5:100237661..100237690,-p@chr5:100237661..100237690
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Hg19::chr5:159846453..159846490,+p@chr5:159846453..159846490
+
Hg19::chr5:169757791..169757802,+p@chr5:169757791..169757802
+
Hg19::chr6:12052345..12052360,+p@chr6:12052345..12052360
+
Hg19::chr9:90216271..90216293,-p@chr9:90216271..90216293
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte9.29e-13142
CD14-positive, CD16-negative classical monocyte9.29e-13142
defensive cell3.87e-11348
phagocyte3.87e-11348
myeloid leukocyte1.09e-10372
granulocyte monocyte progenitor cell3.73e-9767
myeloid lineage restricted progenitor cell1.95e-9466
macrophage dendritic cell progenitor6.22e-9461
monopoietic cell6.85e-9359
monocyte6.85e-9359
monoblast6.85e-9359
promonocyte6.85e-9359
leukocyte5.90e-76136
myeloid cell1.25e-68108
common myeloid progenitor1.25e-68108
nongranular leukocyte1.63e-63115
hematopoietic lineage restricted progenitor cell1.79e-62120
hematopoietic stem cell2.47e-59168
angioblastic mesenchymal cell2.47e-59168
stuff accumulating cell7.75e-5887
hematopoietic cell9.83e-56177
hematopoietic oligopotent progenitor cell9.04e-53161
hematopoietic multipotent progenitor cell9.04e-53161
intermediate monocyte9.35e-339
CD14-positive, CD16-positive monocyte9.35e-339
mesenchymal cell6.00e-22354
connective tissue cell2.74e-21361
motile cell5.80e-19386
stem cell3.97e-16441
multi fate stem cell4.06e-16427
somatic stem cell1.00e-15433
non-classical monocyte7.09e-123
CD14-low, CD16-positive monocyte7.09e-123
basophil7.61e-123
single nucleate cell3.82e-113
mononuclear cell3.82e-113
natural killer cell6.10e-103
pro-NK cell6.10e-103
somatic cell3.12e-08588
granulocyte2.33e-078
Uber Anatomy
Ontology termp-valuen
bone marrow1.58e-8476
bone element1.25e-7782
hematopoietic system4.49e-7398
blood island4.49e-7398
skeletal element7.55e-7090
immune system2.85e-6793
hemolymphoid system2.44e-65108
skeletal system7.46e-62100
musculoskeletal system7.83e-33167
lateral plate mesoderm1.18e-29203
connective tissue2.18e-20371
mesoderm3.83e-15315
mesoderm-derived structure3.83e-15315
presumptive mesoderm3.83e-15315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#1053873.965223547584310.00172000239750150.0106652811490031
BCL11A#5333585.278038158810620.0001140276771569360.00156100885759513
EBF1#1879183.728288447400982.96527101020769e-071.49753355432824e-05
MEF2A#420593.923001818297590.0003757219878006550.00373287944101148
MEF2C#420865.764375045482430.0005669836506498940.00483389432573259
SPI1#6688173.24356975918345.14672540128264e-060.000157861631184892
USF1#7391142.071185811183990.004714302297936050.0222222882151175



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data