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Coexpression cluster:C2595

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Full id: C2595_Melanocyte_granulocyte_Monocytederived_CD14_acute_CD4_Macrophage



Phase1 CAGE Peaks

Hg19::chr1:6086340..6086351,+p5@KCNAB2
Hg19::chr1:6086354..6086365,+p4@KCNAB2
Hg19::chr1:6086385..6086411,+p1@KCNAB2
Hg19::chr1:6086424..6086442,+p3@KCNAB2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.67e-70172
angioblastic mesenchymal cell1.67e-70172
hematopoietic oligopotent progenitor cell9.82e-67165
hematopoietic multipotent progenitor cell9.82e-67165
hematopoietic cell2.28e-66182
leukocyte8.71e-64140
hematopoietic lineage restricted progenitor cell2.30e-55124
nongranular leukocyte4.52e-55119
myeloid cell1.49e-44112
common myeloid progenitor1.49e-44112
myeloid leukocyte4.43e-4076
granulocyte monocyte progenitor cell1.73e-3671
myeloid lineage restricted progenitor cell9.85e-3670
macrophage dendritic cell progenitor5.35e-3465
monopoietic cell6.25e-3463
monocyte6.25e-3463
monoblast6.25e-3463
promonocyte6.25e-3463
classical monocyte3.61e-2645
CD14-positive, CD16-negative classical monocyte7.96e-2642
lymphocyte1.57e-1853
common lymphoid progenitor1.57e-1853
lymphoid lineage restricted progenitor cell4.10e-1852
T cell9.37e-1125
pro-T cell9.37e-1125
mature alpha-beta T cell5.70e-0818
alpha-beta T cell5.70e-0818
immature T cell5.70e-0818
mature T cell5.70e-0818
immature alpha-beta T cell5.70e-0818
mesenchymal cell1.36e-07358
lymphocyte of B lineage1.50e-0724
pro-B cell1.50e-0724
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.84e-40102
blood island8.84e-40102
hemolymphoid system5.25e-34112
bone marrow8.14e-3180
bone element1.98e-2586
immune system2.60e-23115
skeletal element1.03e-16101
skeletal system1.03e-16101
blood5.70e-0715
haemolymphatic fluid5.70e-0715
organism substance5.70e-0715
Disease
Ontology termp-valuen
hematologic cancer6.52e-1251
immune system cancer6.52e-1251
leukemia2.10e-0939


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.