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Coexpression cluster:C965

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Full id: C965_smooth_Osteoblast_Adipocyte_aorta_penis_Preadipocyte_normal



Phase1 CAGE Peaks

Hg19::chrX:153593573..153593599,-p6@FLNA
Hg19::chrX:153594489..153594515,-p@chrX:153594489..153594515
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Hg19::chrX:153594978..153595014,-p@chrX:153594978..153595014
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Hg19::chrX:153595130..153595149,-p@chrX:153595130..153595149
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Hg19::chrX:153595810..153595838,-p@chrX:153595810..153595838
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Hg19::chrX:153595864..153595919,-p@chrX:153595864..153595919
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Hg19::chrX:153596060..153596111,-p@chrX:153596060..153596111
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Hg19::chrX:153596325..153596358,-p@chrX:153596325..153596358
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Hg19::chrX:153599349..153599396,-p5@FLNA


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
somatic cell1.54e-20591
animal cell9.40e-18679
eukaryotic cell9.40e-18679
non-terminally differentiated cell1.54e-15180
multi fate stem cell1.63e-12430
somatic stem cell2.01e-12436
native cell2.26e-12722
stem cell1.69e-11444
CD14-positive, CD16-negative classical monocyte2.21e-1142
classical monocyte1.42e-1045
fibroblast1.78e-1075
mesodermal cell3.95e-09119
smooth muscle cell1.51e-0742
smooth muscle myoblast1.51e-0742
embryonic cell2.40e-07248
connective tissue cell2.59e-07365
mesenchymal cell3.26e-07358
contractile cell5.10e-0759
monopoietic cell5.14e-0763
monocyte5.14e-0763
monoblast5.14e-0763
promonocyte5.14e-0763
muscle precursor cell7.01e-0757
myoblast7.01e-0757
multi-potent skeletal muscle stem cell7.01e-0757
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm1.58e-11216
mesoderm1.26e-10448
mesoderm-derived structure1.26e-10448
presumptive mesoderm1.26e-10448
musculoskeletal system3.50e-09167
artery2.23e-0842
arterial blood vessel2.23e-0842
arterial system2.23e-0842
vasculature3.37e-0879
vascular system3.37e-0879
blood vessel1.11e-0760
epithelial tube open at both ends1.11e-0760
blood vasculature1.11e-0760
vascular cord1.11e-0760
vessel2.36e-0769
cardiovascular system3.10e-07110
connective tissue4.76e-07375
trunk mesenchyme5.78e-07143
somite6.38e-0783
paraxial mesoderm6.38e-0783
presomitic mesoderm6.38e-0783
presumptive segmental plate6.38e-0783
trunk paraxial mesoderm6.38e-0783
presumptive paraxial mesoderm6.38e-0783
dermomyotome9.58e-0770


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.