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Coexpression cluster:C2430

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Full id: C2430_MCF7_CD14_CD19_Natural_Neutrophils_CD8_CD4



Phase1 CAGE Peaks

Hg19::chr17:65713775..65713818,-p@chr17:65713775..65713818
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Hg19::chr1:145507436..145507501,-p1@ENST00000421764
Hg19::chr1:149899786..149899836,+p@chr1:149899786..149899836
+
Hg19::chr9:135905830..135905859,-p@chr9:135905830..135905859
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.45e-44140
hematopoietic stem cell2.95e-39172
angioblastic mesenchymal cell2.95e-39172
hematopoietic cell1.16e-38182
hematopoietic lineage restricted progenitor cell7.12e-37124
hematopoietic oligopotent progenitor cell5.21e-36165
hematopoietic multipotent progenitor cell5.21e-36165
nongranular leukocyte4.58e-35119
CD14-positive, CD16-negative classical monocyte9.30e-2342
classical monocyte9.85e-2345
myeloid leukocyte1.26e-2076
lymphoid lineage restricted progenitor cell9.03e-1952
lymphocyte1.22e-1853
common lymphoid progenitor1.22e-1853
myeloid cell2.57e-17112
common myeloid progenitor2.57e-17112
myeloid lineage restricted progenitor cell5.20e-1770
granulocyte monocyte progenitor cell1.22e-1671
macrophage dendritic cell progenitor8.78e-1665
monopoietic cell4.57e-1563
monocyte4.57e-1563
monoblast4.57e-1563
promonocyte4.57e-1563
native cell2.17e-13722
mature alpha-beta T cell7.76e-1118
alpha-beta T cell7.76e-1118
immature T cell7.76e-1118
mature T cell7.76e-1118
immature alpha-beta T cell7.76e-1118
T cell1.17e-0925
pro-T cell1.17e-0925
lymphocyte of B lineage1.44e-0824
pro-B cell1.44e-0824
B cell5.02e-0814
CD8-positive, alpha-beta T cell1.18e-0711
mesenchymal cell5.54e-07358
connective tissue cell8.56e-07365
motile cell9.13e-07390
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.82e-20102
blood island1.82e-20102
hemolymphoid system2.98e-20112
bone marrow7.02e-1580
bone element6.21e-1486
immune system1.24e-10115
skeletal element6.47e-10101
skeletal system6.47e-10101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.