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Coexpression cluster:C2670

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Full id: C2670_uterus_lung_cervix_adipose_penis_ductus_seminal



Phase1 CAGE Peaks

  Short description
Hg19::chr2:173686542..173686585,+ p5@RAPGEF4
Hg19::chr5:38557323..38557328,- p12@LIFR
Hg19::chr5:38557343..38557361,- p4@LIFR
Hg19::chr5:38557372..38557385,- p5@LIFR


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0004923leukemia inhibitory factor receptor activity0.0046508889673849
GO:0030552cAMP binding0.022470032592992
GO:0016208AMP binding0.022470032592992
GO:0005952cAMP-dependent protein kinase complex0.022470032592992
GO:0030551cyclic nucleotide binding0.022470032592992
GO:0008603cAMP-dependent protein kinase regulator activity0.022470032592992
GO:0004896hematopoietin/interferon-class (D200-domain) cytokine receptor activity0.0457985933512357



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
endothelial cell of vascular tree5.68e-1024
Uber Anatomy
Ontology termp-valuen
adult organism8.90e-78114
neural tube1.12e-2256
neural rod1.12e-2256
future spinal cord1.12e-2256
neural keel1.12e-2256
anatomical cluster2.82e-21373
regional part of nervous system1.71e-2053
regional part of brain1.71e-2053
anatomical conduit3.71e-20240
regional part of forebrain3.49e-1941
forebrain3.49e-1941
anterior neural tube3.49e-1941
future forebrain3.49e-1941
telencephalon6.76e-1834
brain grey matter8.84e-1834
gray matter8.84e-1834
central nervous system1.16e-1781
neural plate2.89e-1782
presumptive neural plate2.89e-1782
neurectoderm9.15e-1786
nervous system1.60e-1689
cerebral hemisphere3.20e-1632
structure with developmental contribution from neural crest3.41e-16132
regional part of telencephalon3.99e-1632
tube7.16e-16192
brain2.71e-1568
future brain2.71e-1568
organ system subdivision1.49e-14223
pre-chordal neural plate2.89e-1261
ecto-epithelium6.87e-12104
regional part of cerebral cortex3.19e-1122
neocortex4.03e-1120
cerebral cortex1.47e-1025
pallium1.47e-1025
multi-tissue structure5.44e-10342
multi-cellular organism1.49e-09656
neural nucleus1.60e-099
nucleus of brain1.60e-099
ectoderm-derived structure7.06e-09171
ectoderm7.06e-09171
presumptive ectoderm7.06e-09171
epithelium3.06e-08306
anatomical system3.52e-08624
anatomical group4.11e-08625
cell layer5.64e-08309
telencephalic nucleus9.20e-087
basal ganglion1.33e-079
nuclear complex of neuraxis1.33e-079
aggregate regional part of brain1.33e-079
collection of basal ganglia1.33e-079
cerebral subcortex1.33e-079
compound organ1.98e-0768
embryo3.54e-07592
embryonic structure6.60e-07564
organ8.56e-07503


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.12.49947
MA0031.12.36201
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.90157
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.00910927
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MXI1#460137.471178721569470.003741314738550960.0186385789915819
SMARCA4#65973117.5744274809161.03069197590886e-064.32828465106337e-05
SMARCB1#6598313.68953683586810.0006305783409379340.00518232383925219
SMARCC1#6599332.74751948972364.71941722862287e-050.000824922537138316
SMARCC2#6601370.61653082017324.74678670742709e-060.000147237795348078
ZNF263#1012736.166381227758010.006539814347975980.0279808140388473



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.