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|ontology_enrichment_disease=DOID:2394!7.95e-07!14
|ontology_enrichment_disease=DOID:2394!7.95e-07!14
|ontology_enrichment_uberon=UBERON:0004535!1.47e-38!110;UBERON:0001009!2.23e-38!113;UBERON:0002049!9.27e-33!79;UBERON:0007798!9.27e-33!79;UBERON:0000055!1.70e-30!69;UBERON:0004872!9.16e-30!84;UBERON:0001981!2.80e-27!60;UBERON:0007500!2.80e-27!60;UBERON:0004537!2.80e-27!60;UBERON:0006965!2.80e-27!60;UBERON:0003914!2.09e-25!118;UBERON:0000914!5.59e-23!83;UBERON:0002329!5.59e-23!83;UBERON:0003077!5.59e-23!83;UBERON:0003059!5.59e-23!83;UBERON:0007282!5.59e-23!83;UBERON:0009618!5.59e-23!83;UBERON:0007285!5.59e-23!83;UBERON:0004290!1.66e-22!70;UBERON:0000477!2.37e-21!286;UBERON:0001637!2.82e-20!42;UBERON:0003509!2.82e-20!42;UBERON:0004572!2.82e-20!42;UBERON:0000490!5.32e-20!138;UBERON:0001134!6.89e-20!61;UBERON:0002036!6.89e-20!61;UBERON:0003082!6.89e-20!61;UBERON:0002385!1.27e-19!63;UBERON:0001015!1.27e-19!63;UBERON:0000383!1.27e-19!63;UBERON:0005256!2.06e-19!143;UBERON:0000486!4.70e-17!82;UBERON:0004573!1.09e-15!33;UBERON:0004571!1.09e-15!33;UBERON:0000119!1.24e-15!312;UBERON:0000468!3.18e-15!659;UBERON:0004111!3.44e-15!241;UBERON:0000483!4.46e-15!309;UBERON:0002100!1.05e-14!216;UBERON:0000481!1.49e-14!347;UBERON:0000467!1.49e-13!625;UBERON:0003104!3.20e-13!238;UBERON:0009142!3.20e-13!238;UBERON:0000480!3.21e-13!626;UBERON:0000475!3.60e-13!365;UBERON:0000025!2.08e-12!194;UBERON:0001986!2.63e-12!18;UBERON:0004638!2.63e-12!18;UBERON:0004852!2.63e-12!18;UBERON:0000487!1.88e-11!22;UBERON:0000926!5.43e-11!448;UBERON:0004120!5.43e-11!448;UBERON:0006603!5.43e-11!448;UBERON:0006914!3.30e-10!25;UBERON:0000947!1.47e-09!21;UBERON:0010191!1.47e-09!21;UBERON:0002050!6.49e-09!605;UBERON:0005423!6.49e-09!605;UBERON:0000948!8.23e-09!24;UBERON:0005498!8.23e-09!24;UBERON:0004140!8.23e-09!24;UBERON:0009881!8.23e-09!24;UBERON:0004141!8.23e-09!24;UBERON:0003084!8.23e-09!24;UBERON:0007005!8.23e-09!24;UBERON:0004139!8.23e-09!24;UBERON:0004291!8.23e-09!24;UBERON:0000923!9.30e-09!604;UBERON:0005291!9.30e-09!604;UBERON:0006598!9.30e-09!604;UBERON:0002532!9.30e-09!604;UBERON:0000922!1.12e-08!612;UBERON:0007100!1.37e-08!27;UBERON:0003103!1.24e-07!69;UBERON:0000479!2.06e-07!787;UBERON:0003915!7.23e-07!9;UBERON:0004700!7.23e-07!9;UBERON:0001917!7.23e-07!9
|ontology_enrichment_uberon=UBERON:0004535!1.47e-38!110;UBERON:0001009!2.23e-38!113;UBERON:0002049!9.27e-33!79;UBERON:0007798!9.27e-33!79;UBERON:0000055!1.70e-30!69;UBERON:0004872!9.16e-30!84;UBERON:0001981!2.80e-27!60;UBERON:0007500!2.80e-27!60;UBERON:0004537!2.80e-27!60;UBERON:0006965!2.80e-27!60;UBERON:0003914!2.09e-25!118;UBERON:0000914!5.59e-23!83;UBERON:0002329!5.59e-23!83;UBERON:0003077!5.59e-23!83;UBERON:0003059!5.59e-23!83;UBERON:0007282!5.59e-23!83;UBERON:0009618!5.59e-23!83;UBERON:0007285!5.59e-23!83;UBERON:0004290!1.66e-22!70;UBERON:0000477!2.37e-21!286;UBERON:0001637!2.82e-20!42;UBERON:0003509!2.82e-20!42;UBERON:0004572!2.82e-20!42;UBERON:0000490!5.32e-20!138;UBERON:0001134!6.89e-20!61;UBERON:0002036!6.89e-20!61;UBERON:0003082!6.89e-20!61;UBERON:0002385!1.27e-19!63;UBERON:0001015!1.27e-19!63;UBERON:0000383!1.27e-19!63;UBERON:0005256!2.06e-19!143;UBERON:0000486!4.70e-17!82;UBERON:0004573!1.09e-15!33;UBERON:0004571!1.09e-15!33;UBERON:0000119!1.24e-15!312;UBERON:0000468!3.18e-15!659;UBERON:0004111!3.44e-15!241;UBERON:0000483!4.46e-15!309;UBERON:0002100!1.05e-14!216;UBERON:0000481!1.49e-14!347;UBERON:0000467!1.49e-13!625;UBERON:0003104!3.20e-13!238;UBERON:0009142!3.20e-13!238;UBERON:0000480!3.21e-13!626;UBERON:0000475!3.60e-13!365;UBERON:0000025!2.08e-12!194;UBERON:0001986!2.63e-12!18;UBERON:0004638!2.63e-12!18;UBERON:0004852!2.63e-12!18;UBERON:0000487!1.88e-11!22;UBERON:0000926!5.43e-11!448;UBERON:0004120!5.43e-11!448;UBERON:0006603!5.43e-11!448;UBERON:0006914!3.30e-10!25;UBERON:0000947!1.47e-09!21;UBERON:0010191!1.47e-09!21;UBERON:0002050!6.49e-09!605;UBERON:0005423!6.49e-09!605;UBERON:0000948!8.23e-09!24;UBERON:0005498!8.23e-09!24;UBERON:0004140!8.23e-09!24;UBERON:0009881!8.23e-09!24;UBERON:0004141!8.23e-09!24;UBERON:0003084!8.23e-09!24;UBERON:0007005!8.23e-09!24;UBERON:0004139!8.23e-09!24;UBERON:0004291!8.23e-09!24;UBERON:0000923!9.30e-09!604;UBERON:0005291!9.30e-09!604;UBERON:0006598!9.30e-09!604;UBERON:0002532!9.30e-09!604;UBERON:0000922!1.12e-08!612;UBERON:0007100!1.37e-08!27;UBERON:0003103!1.24e-07!69;UBERON:0000479!2.06e-07!787;UBERON:0003915!7.23e-07!9;UBERON:0004700!7.23e-07!9;UBERON:0001917!7.23e-07!9
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}}
}}

Revision as of 13:23, 5 September 2012


Full id: C2004_Endothelial_mesenchymal_Renal_Smooth_Hepatic_leiomyoma_Preadipocyte



Phase1 CAGE Peaks

Hg19::chr7:93551017..93551029,+p7@GNG11
Hg19::chr7:93551089..93551142,+p2@GNG11
Hg19::chr7:93551321..93551336,+p6@GNG11
Hg19::chr7:93551356..93551375,+p1@GNG11
Hg19::chr7:93551389..93551406,+p5@GNG11


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
cardiovascular system1.47e-38110
circulatory system2.23e-38113
vasculature9.27e-3379
vascular system9.27e-3379
vessel1.70e-3069
splanchnic layer of lateral plate mesoderm9.16e-3084
blood vessel2.80e-2760
epithelial tube open at both ends2.80e-2760
blood vasculature2.80e-2760
vascular cord2.80e-2760
epithelial tube2.09e-25118
somite5.59e-2383
paraxial mesoderm5.59e-2383
presomitic mesoderm5.59e-2383
presumptive segmental plate5.59e-2383
trunk paraxial mesoderm5.59e-2383
presumptive paraxial mesoderm5.59e-2383
dermomyotome1.66e-2270
anatomical cluster2.37e-21286
artery2.82e-2042
arterial blood vessel2.82e-2042
arterial system2.82e-2042
unilaminar epithelium5.32e-20138
skeletal muscle tissue6.89e-2061
striated muscle tissue6.89e-2061
myotome6.89e-2061
muscle tissue1.27e-1963
musculature1.27e-1963
musculature of body1.27e-1963
trunk mesenchyme2.06e-19143
multilaminar epithelium4.70e-1782
systemic artery1.09e-1533
systemic arterial system1.09e-1533
cell layer1.24e-15312
multi-cellular organism3.18e-15659
anatomical conduit3.44e-15241
epithelium4.46e-15309
trunk1.05e-14216
multi-tissue structure1.49e-14347
anatomical system1.49e-13625
mesenchyme3.20e-13238
entire embryonic mesenchyme3.20e-13238
anatomical group3.21e-13626
organism subdivision3.60e-13365
tube2.08e-12194
endothelium2.63e-1218
blood vessel endothelium2.63e-1218
cardiovascular system endothelium2.63e-1218
simple squamous epithelium1.88e-1122
mesoderm5.43e-11448
mesoderm-derived structure5.43e-11448
presumptive mesoderm5.43e-11448
squamous epithelium3.30e-1025
aorta1.47e-0921
aortic system1.47e-0921
embryonic structure6.49e-09605
developing anatomical structure6.49e-09605
heart8.23e-0924
primitive heart tube8.23e-0924
primary heart field8.23e-0924
anterior lateral plate mesoderm8.23e-0924
heart tube8.23e-0924
heart primordium8.23e-0924
cardiac mesoderm8.23e-0924
cardiogenic plate8.23e-0924
heart rudiment8.23e-0924
germ layer9.30e-09604
embryonic tissue9.30e-09604
presumptive structure9.30e-09604
epiblast (generic)9.30e-09604
embryo1.12e-08612
primary circulatory organ1.37e-0827
compound organ1.24e-0769
tissue2.06e-07787
endothelial tube7.23e-079

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066444.288205098460020.005152015588243280.0239472765152227
EBF1#187947.12517347725520.0007230531046774210.00577463815855358
FOS#235358.99795530889441.69470025615156e-050.000389937871892956
GATA2#2624410.19594538684320.0001775447777609820.0021583749324385
NR3C1#2908514.9730233311731.32777388277837e-065.26067437570144e-05
RAD21#588536.21302033727380.007751055068811640.0318994538492185
REST#597847.720022972902420.0005286363773650570.00457492994826228
SMARCB1#6598414.60217262492594.30486693344344e-050.000768934492324097
TFAP2A#7020516.5186343730458.12390055913032e-073.54407706973689e-05
TFAP2C#7022510.80922860986026.77323239348459e-060.000197539686663819



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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