Coexpression cluster:C4701

Full id: C4701_Mast_optic_mature_small_substantia_adrenal_serous

Phase1 CAGE Peaks

Hg19::chr7:79764112..79764209,+	p1@GNAI1
Hg19::chr7:79764242..79764256,+	p3@GNAI1
Hg19::chr7:79764393..79764437,+	p2@GNAI1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.81e-24	94
nervous system	1.81e-24	94
central nervous system	1.05e-23	82
neural tube	7.51e-23	57
neural rod	7.51e-23	57
future spinal cord	7.51e-23	57
neural keel	7.51e-23	57
ectoderm-derived structure	9.36e-23	169
head	3.48e-22	123
ectoderm	8.54e-22	173
presumptive ectoderm	8.54e-22	173
regional part of brain	3.53e-21	59
brain	1.62e-20	69
future brain	1.62e-20	69
organism subdivision	1.94e-20	365
anterior region of body	9.94e-20	129
craniocervical region	9.94e-20	129
neural plate	4.78e-19	86
presumptive neural plate	4.78e-19	86
anterior neural tube	5.04e-18	42
neurectoderm	1.15e-17	90
regional part of forebrain	1.52e-17	41
forebrain	1.52e-17	41
future forebrain	1.52e-17	41
telencephalon	3.21e-17	34
gray matter	3.40e-17	34
brain grey matter	3.40e-17	34
regional part of telencephalon	1.38e-16	33
multi-cellular organism	4.26e-16	659
cerebral hemisphere	6.64e-16	32
pre-chordal neural plate	2.99e-15	61
anatomical system	1.26e-14	625
organ	2.06e-14	511
anatomical group	2.88e-14	626
organ part	3.17e-14	219
regional part of cerebral cortex	2.06e-13	22
adult organism	3.07e-13	115
multi-tissue structure	2.43e-12	347
neocortex	2.45e-12	20
cerebral cortex	4.27e-12	25
pallium	4.27e-12	25
anatomical cluster	1.49e-10	286
epithelium	3.34e-10	309
cell layer	4.47e-10	312
embryo	2.08e-09	612
embryonic structure	3.29e-09	605
developing anatomical structure	3.29e-09	605
anatomical conduit	3.34e-09	241
germ layer	5.76e-09	604
embryonic tissue	5.76e-09	604
presumptive structure	5.76e-09	604
epiblast (generic)	5.76e-09	604

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BHLHE40#8553	3	44.8718135469774	1.10603738662898e-05	0.000285853597184222
CTBP2#1488	2	41.8113335595521	0.000754340825991485	0.00593644800887082
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0281322314172399
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0327741580253814
NR3C1#2908	2	9.98201555411536	0.0127847436554717	0.0460819962945232
SMARCB1#6598	2	12.1684771874383	0.00867500222192174	0.0330141951337421
SMC3#9126	2	10.0299552299552	0.012665637976747	0.0457822505331215
TFAP2A#7020	2	11.0124229153633	0.0105499065521556	0.0390357007865295
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0191197828711203

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.