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Coexpression cluster:C3374: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0278743391371263!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00662625246284153
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0278743391371263!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00662625246284153
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}}
}}

Revision as of 16:05, 26 November 2012


Full id: C3374_caudate_putamen_amygdala_Mallassezderived_mesenchymal_astrocytoma_hippocampus



Phase1 CAGE Peaks

Hg19::chr13:45768800..45768816,-p1@KCTD4
Hg19::chr13:45768841..45768855,-p3@KCTD4
Hg19::chr13:45768859..45768871,-p4@KCTD4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
epithelial cell of Malassez5.31e-073
Uber Anatomy
Ontology termp-valuen
neural tube3.67e-5556
neural rod3.67e-5556
future spinal cord3.67e-5556
neural keel3.67e-5556
regional part of nervous system4.58e-5353
regional part of brain4.58e-5353
regional part of forebrain5.43e-4741
forebrain5.43e-4741
anterior neural tube5.43e-4741
future forebrain5.43e-4741
brain7.03e-4468
future brain7.03e-4468
ecto-epithelium3.09e-43104
brain grey matter1.72e-4234
gray matter1.72e-4234
central nervous system2.85e-4281
telencephalon4.75e-4234
nervous system5.69e-4289
regional part of telencephalon1.93e-3932
cerebral hemisphere4.09e-3932
neural plate5.55e-3782
presumptive neural plate5.55e-3782
neurectoderm1.46e-3486
pre-chordal neural plate5.18e-3261
cerebral cortex5.54e-3125
pallium5.54e-3125
regional part of cerebral cortex8.72e-3022
structure with developmental contribution from neural crest1.03e-29132
adult organism1.63e-29114
ectoderm-derived structure2.58e-29171
ectoderm2.58e-29171
presumptive ectoderm2.58e-29171
neocortex2.55e-2620
organ system subdivision7.36e-17223
tube6.52e-15192
basal ganglion2.46e-139
nuclear complex of neuraxis2.46e-139
aggregate regional part of brain2.46e-139
collection of basal ganglia2.46e-139
cerebral subcortex2.46e-139
neural nucleus8.37e-139
nucleus of brain8.37e-139
anatomical cluster2.26e-12373
anatomical conduit2.36e-12240
multi-tissue structure1.76e-11342
epithelium4.53e-11306
cell layer8.74e-11309
gyrus1.18e-106
limbic system1.68e-105
organ2.59e-10503
brainstem5.72e-106
telencephalic nucleus7.62e-107
organ part7.76e-10218
posterior neural tube8.09e-1015
chordal neural plate8.09e-1015
temporal lobe1.22e-096
segmental subdivision of nervous system2.71e-0913
occipital lobe1.23e-085
anatomical system3.17e-08624
anatomical group3.62e-08625
segmental subdivision of hindbrain7.07e-0812
hindbrain7.07e-0812
presumptive hindbrain7.07e-0812
developing anatomical structure4.99e-07581
embryo7.61e-07592
primary subdivision of cranial skeletal system8.78e-075


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0278743391371263
RAD21#5885310.35503389545630.0009004912073565420.00662625246284153



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.