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Coexpression cluster:C3524: Difference between revisions

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|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0324635139118418!STAT3#6774;3:10.5194649971542:0.000858918453041531:0.00642168976427836
|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0324635139118418!STAT3#6774;3:10.5194649971542:0.000858918453041531:0.00642168976427836
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}}
}}

Revision as of 16:11, 26 November 2012


Full id: C3524_adrenal_trachea_skeletal_diaphragm_stomach_aorta_throat



Phase1 CAGE Peaks

Hg19::chr15:84322458..84322470,+p2@ADAMTSL3
Hg19::chr15:84322827..84322861,+p3@ADAMTSL3
Hg19::chr15:84322865..84322888,+p1@ADAMTSL3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism5.22e-47114
nervous system1.82e-2089
neural tube4.41e-2056
neural rod4.41e-2056
future spinal cord4.41e-2056
neural keel4.41e-2056
central nervous system3.23e-1981
neural plate4.56e-1882
presumptive neural plate4.56e-1882
regional part of nervous system4.92e-1853
regional part of brain4.92e-1853
neurectoderm4.94e-1886
brain4.21e-1668
future brain4.21e-1668
organ system subdivision8.83e-16223
anatomical cluster2.01e-15373
structure with developmental contribution from neural crest2.80e-15132
regional part of forebrain5.72e-1541
forebrain5.72e-1541
anterior neural tube5.72e-1541
future forebrain5.72e-1541
telencephalon1.96e-1234
brain grey matter2.63e-1234
gray matter2.63e-1234
pre-chordal neural plate2.94e-1261
ecto-epithelium1.52e-11104
regional part of telencephalon2.50e-1132
cerebral hemisphere2.56e-1132
ectoderm-derived structure2.76e-11171
ectoderm2.76e-11171
presumptive ectoderm2.76e-11171
multi-cellular organism1.11e-10656
cerebral cortex3.76e-1025
pallium3.76e-1025
multi-tissue structure1.60e-09342
anatomical conduit6.85e-09240
embryo7.19e-09592
organ8.91e-09503
regional part of cerebral cortex5.35e-0822
neocortex5.43e-0820
developing anatomical structure9.85e-08581
tube1.27e-07192
anatomical system3.06e-07624
anatomical group3.73e-07625
embryonic structure7.19e-07564
germ layer8.34e-07560
germ layer / neural crest8.34e-07560
embryonic tissue8.34e-07560
presumptive structure8.34e-07560
germ layer / neural crest derived structure8.34e-07560
epiblast (generic)8.34e-07560


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0324635139118418
STAT3#6774310.51946499715420.0008589184530415310.00642168976427836



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.