MCL coexpression mm9:1723

Phase1 CAGE Peaks

	Short description
Mm9::chr18:82754158..82754162,+	p@chr18:82754158..82754162 +
Mm9::chr1:187242150..187242173,+	p@chr1:187242150..187242173 +
Mm9::chr2:102627166..102627177,+	p@chr2:102627166..102627177 +
Mm9::chr7:116902855..116902862,-	p@chr7:116902855..116902862 -
Mm9::chr7:116903722..116903727,-	p@chr7:116903722..116903727 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019911	structural constituent of myelin sheath	0.00591602515206222
GO:0015501	glutamate:sodium symporter activity	0.00591602515206222
GO:0015813	L-glutamate transport	0.00591602515206222
GO:0015800	acidic amino acid transport	0.00591602515206222
GO:0043209	myelin sheath	0.00591602515206222
GO:0005313	L-glutamate transmembrane transporter activity	0.00591602515206222
GO:0005283	sodium:amino acid symporter activity	0.00591602515206222
GO:0015172	acidic amino acid transmembrane transporter activity	0.00591602515206222
GO:0017153	sodium:dicarboxylate symporter activity	0.006572640891973
GO:0005416	cation:amino acid symporter activity	0.006572640891973
GO:0005310	dicarboxylic acid transmembrane transporter activity	0.006572640891973
GO:0006835	dicarboxylic acid transport	0.006572640891973
GO:0015296	anion:cation symporter activity	0.0107013754591181
GO:0005343	organic acid:sodium symporter activity	0.0107013754591181
GO:0015179	L-amino acid transmembrane transporter activity	0.0120893513204155
GO:0042552	myelination	0.0127004901604651
GO:0007272	ensheathment of neurons	0.0127004901604651
GO:0008366	axon ensheathment	0.0127004901604651
GO:0005275	amine transmembrane transporter activity	0.0138861597757711
GO:0015171	amino acid transmembrane transporter activity	0.0138861597757711
GO:0001508	regulation of action potential	0.0138861597757711
GO:0015370	solute:sodium symporter activity	0.0143285192318228
GO:0006865	amino acid transport	0.0154166184691794
GO:0015294	solute:cation symporter activity	0.0157527264978516
GO:0015837	amine transport	0.0157527264978516
GO:0046943	carboxylic acid transmembrane transporter activity	0.0157527264978516
GO:0005342	organic acid transmembrane transporter activity	0.0157527264978516
GO:0044459	plasma membrane part	0.0157527264978516
GO:0046942	carboxylic acid transport	0.0157527264978516
GO:0015849	organic acid transport	0.0157527264978516
GO:0005886	plasma membrane	0.0249424292848134
GO:0008509	anion transmembrane transporter activity	0.0275279381811922
GO:0015293	symporter activity	0.0316805465969565
GO:0015291	secondary active transmembrane transporter activity	0.0406419911411715

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.36e-21	23
neuroblast (sensu Vertebrata)	3.36e-21	23
neuron	4.25e-14	33
neuronal stem cell	4.25e-14	33
neuroblast	4.25e-14	33
electrically signaling cell	4.25e-14	33
raphe nuclei neuron	1.92e-12	3
neuron of the substantia nigra	2.95e-12	3
electrically responsive cell	1.39e-11	39
electrically active cell	1.39e-11	39
neuron of the ventral spinal cord	1.57e-11	3
neural cell	2.68e-10	43
ectodermal cell	5.16e-10	44
neurectodermal cell	5.16e-10	44
non-terminally differentiated cell	9.17e-09	49
neuron of the dorsal spinal cord	3.49e-08	2

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	6.44e-32	54
neural tube	8.82e-27	52
neural rod	8.82e-27	52
future spinal cord	8.82e-27	52
neural keel	8.82e-27	52
central nervous system	7.50e-25	73
gray matter	3.52e-24	34
nervous system	4.38e-24	75
spinal cord	3.92e-21	6
dorsal region element	3.92e-21	6
dorsum	3.92e-21	6
neurectoderm	4.58e-21	64
neural plate	4.58e-21	64
presumptive neural plate	4.58e-21	64
ectoderm-derived structure	3.49e-18	95
ectoderm	3.49e-18	95
presumptive ectoderm	3.49e-18	95
regional part of spinal cord	4.56e-18	5
gray matter of spinal cord	4.56e-18	5
ecto-epithelium	5.25e-18	73
regional part of midbrain	2.90e-15	4
midbrain	2.90e-15	4
presumptive midbrain	2.90e-15	4
midbrain neural tube	2.90e-15	4
anterior neural tube	6.82e-15	40
regional part of brain	1.02e-14	46
brain	2.41e-14	47
future brain	2.41e-14	47
posterior neural tube	5.43e-14	12
chordal neural plate	5.43e-14	12
structure with developmental contribution from neural crest	1.67e-13	92
regional part of forebrain	3.79e-13	39
forebrain	3.79e-13	39
future forebrain	3.79e-13	39
brain grey matter	4.31e-13	29
regional part of telencephalon	4.31e-13	29
telencephalon	4.31e-13	29
raphe nuclei	1.92e-12	3
reticular formation	1.92e-12	3
occipital lobe	2.58e-12	10
visual cortex	2.58e-12	10
neocortex	2.58e-12	10
substantia nigra	2.95e-12	3
telencephalic nucleus	2.95e-12	3
midbrain nucleus	2.95e-12	3
neural nucleus	2.95e-12	3
nucleus of brain	2.95e-12	3
pre-chordal neural plate	1.13e-11	49
ventral horn of spinal cord	1.57e-11	3
tube	3.74e-10	114
regional part of cerebral cortex	2.09e-09	17
anatomical conduit	3.12e-09	122
dorsal horn of spinal cord	3.49e-08	2
basal ganglion	1.38e-07	8
nuclear complex of neuraxis	1.38e-07	8
aggregate regional part of brain	1.38e-07	8
collection of basal ganglia	1.38e-07	8
cerebral subcortex	1.38e-07	8
cerebral cortex	1.87e-07	21
cerebral hemisphere	1.87e-07	21
pallium	1.87e-07	21
organ system subdivision	8.89e-07	194

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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