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Coexpression cluster:C2771

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Full id: C2771_tubular_Mast_mucinous_smallcell_bile_gall_cerebellum



Phase1 CAGE Peaks

Hg19::chr4:11430464..11430477,-p3@HS3ST1
Hg19::chr4:11430488..11430492,-p8@HS3ST1
Hg19::chr4:11430494..11430527,-p1@HS3ST1
Hg19::chr4:11430734..11430759,-p4@HS3ST1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism1.39e-20115
anatomical conduit2.47e-17241
embryo7.95e-16612
tube1.21e-15194
embryonic structure5.76e-15605
developing anatomical structure5.76e-15605
germ layer1.24e-14604
embryonic tissue1.24e-14604
presumptive structure1.24e-14604
epiblast (generic)1.24e-14604
anatomical system4.58e-14625
anatomical group8.04e-14626
neural tube9.54e-1457
neural rod9.54e-1457
future spinal cord9.54e-1457
neural keel9.54e-1457
central nervous system2.74e-1382
organ3.17e-13511
anatomical cluster8.94e-13286
neural plate1.33e-1286
presumptive neural plate1.33e-1286
multi-cellular organism8.22e-12659
cell layer1.01e-11312
epithelium1.90e-11309
regional part of brain3.24e-1159
neurectoderm6.19e-1190
anterior region of body1.16e-10129
craniocervical region1.16e-10129
ectoderm-derived structure1.90e-10169
head1.96e-10123
anterior neural tube4.99e-1042
regional part of forebrain7.38e-1041
forebrain7.38e-1041
future forebrain7.38e-1041
regional part of nervous system8.78e-1094
nervous system8.78e-1094
brain1.17e-0969
future brain1.17e-0969
ectoderm1.97e-09173
presumptive ectoderm1.97e-09173
pre-chordal neural plate8.32e-0961
gray matter1.07e-0834
brain grey matter1.07e-0834
telencephalon1.17e-0834
cerebral hemisphere2.18e-0832
organ part2.29e-08219
regional part of telencephalon2.88e-0833
compound organ8.04e-0869
cerebral cortex2.36e-0725
pallium2.36e-0725
regional part of cerebral cortex6.14e-0722
neocortex8.54e-0720
Disease
Ontology termp-valuen
squamous cell carcinoma3.05e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00819028830053602
RAD21#5885410.35503389545638.6948481184721e-050.00129744426724547
REST#597837.237521537096020.004104697304192610.0195883245032018
SMC3#9126415.04493284493281.95092670935632e-050.000439027870283268
YY1#752844.911170749853860.00171871838055440.0106998825075537
ZNF263#1012748.221841637010680.0002187871180958320.00249616646567736



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.