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Coexpression cluster:C4474: Difference between revisions

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|tf_chipseq_enrich=CEBPB#1051;3:7.97114762582482:0.00197418705528856:0.0115624787947107
|tf_chipseq_enrich=CEBPB#1051;3:7.97114762582482:0.00197418705528856:0.0115624787947107
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}}
}}

Revision as of 16:45, 26 November 2012


Full id: C4474_occipital_medial_Smooth_insula_Mesenchymal_hippocampus_parietal



Phase1 CAGE Peaks

Hg19::chr5:143584901..143584987,+p1@KCTD16
Hg19::chr5:143584993..143585004,+p4@KCTD16
Hg19::chr5:143585025..143585036,+p6@KCTD16


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
cerebral hemisphere7.31e-2832
telencephalon4.48e-2734
brain grey matter1.10e-2634
gray matter1.10e-2634
regional part of cerebral cortex1.18e-2522
regional part of telencephalon1.37e-2532
regional part of forebrain1.44e-2441
forebrain1.44e-2441
anterior neural tube1.44e-2441
future forebrain1.44e-2441
neural tube3.21e-2456
neural rod3.21e-2456
future spinal cord3.21e-2456
neural keel3.21e-2456
neocortex1.36e-2320
regional part of nervous system6.49e-2253
regional part of brain6.49e-2253
cerebral cortex1.41e-2125
pallium1.41e-2125
tube3.55e-21192
neural plate8.33e-2182
presumptive neural plate8.33e-2182
central nervous system1.70e-2081
brain3.49e-2068
future brain3.49e-2068
structure with developmental contribution from neural crest5.30e-20132
neurectoderm4.95e-1986
nervous system7.63e-1989
pre-chordal neural plate2.73e-1861
ecto-epithelium1.03e-13104
epithelium1.83e-13306
anatomical conduit2.03e-13240
cell layer4.91e-13309
adult organism3.89e-12114
anatomical cluster1.18e-11373
artery7.23e-1142
arterial blood vessel7.23e-1142
arterial system7.23e-1142
multi-tissue structure5.42e-10342
systemic artery6.05e-1033
systemic arterial system6.05e-1033
ectoderm-derived structure3.92e-09171
ectoderm3.92e-09171
presumptive ectoderm3.92e-09171
splanchnic layer of lateral plate mesoderm2.11e-0883
temporal lobe2.79e-086
gyrus6.45e-086
epithelial tube open at both ends8.70e-0859
blood vessel8.70e-0859
blood vasculature8.70e-0859
vascular cord8.70e-0859
omentum9.00e-086
peritoneum9.00e-086
abdominal cavity9.00e-086
visceral peritoneum9.00e-086
basal ganglion1.54e-079
nuclear complex of neuraxis1.54e-079
aggregate regional part of brain1.54e-079
collection of basal ganglia1.54e-079
cerebral subcortex1.54e-079
skeletal muscle tissue1.67e-0762
striated muscle tissue1.67e-0762
myotome1.67e-0762
parietal lobe4.03e-075
muscle tissue5.21e-0764
musculature5.21e-0764
musculature of body5.21e-0764
occipital lobe5.75e-075
organ part8.32e-07218


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.0115624787947107



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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