Coexpression cluster:C88

Full id: C88_Melanocyte_melanoma_Macrophage_Mesenchymal_migratory_Dendritic_Monocytederived

Phase1 CAGE Peaks

Hg19::chr10:106240041..106240047,-	p1@ENST00000447860
Hg19::chr10:29811685..29811692,-	p36@SVIL
Hg19::chr10:4046629..4046639,+	p@chr10:4046629..4046639 +
Hg19::chr10:93335091..93335099,-	p6@BC044257
Hg19::chr11:109962897..109962926,+	p@chr11:109962897..109962926 +
Hg19::chr11:12398061..12398074,+	p@chr11:12398061..12398074 +
Hg19::chr11:126225529..126225660,+	p1@ST3GAL4
Hg19::chr11:14586167..14586191,+	p@chr11:14586167..14586191 +
Hg19::chr11:2920725..2920736,-	p5@SLC22A18AS
Hg19::chr11:2920738..2920749,-	p7@SLC22A18AS
Hg19::chr11:2920857..2920864,+	p13@SLC22A18
Hg19::chr11:61112944..61112955,+	p9@DAK
Hg19::chr11:88909137..88909155,-	p@chr11:88909137..88909155 -
Hg19::chr12:124850619..124850624,-	p@chr12:124850619..124850624 -
Hg19::chr12:132312931..132312971,+	p1@MMP17
Hg19::chr12:28947878..28947885,-	p@chr12:28947878..28947885 -
Hg19::chr12:56351171..56351183,-	p8@PMEL
Hg19::chr12:56364848..56364864,+	p12@CDK2
Hg19::chr12:63025600..63025629,+	p@chr12:63025600..63025629 +
Hg19::chr12:89817974..89818019,+	p@chr12:89817974..89818019 +
Hg19::chr13:49155067..49155077,-	p@chr13:49155067..49155077 -
Hg19::chr13:49155365..49155378,+	p@chr13:49155365..49155378 +
Hg19::chr13:52459545..52459551,-	p@chr13:52459545..52459551 -
Hg19::chr14:93559337..93559385,-	p@chr14:93559337..93559385 -
Hg19::chr15:28341225..28341238,-	p@chr15:28341225..28341238 -
Hg19::chr15:28344444..28344469,-	p1@OCA2
Hg19::chr15:28360857..28360860,-	p@chr15:28360857..28360860 -
Hg19::chr15:28413731..28413765,-	p@chr15:28413731..28413765 -
Hg19::chr15:42694546..42694554,+	p18@CAPN3
Hg19::chr15:42694558..42694570,+	p10@CAPN3
Hg19::chr15:42694573..42694641,+	p7@CAPN3
Hg19::chr15:42694649..42694650,+	p24@CAPN3
Hg19::chr15:42694665..42694671,+	p16@CAPN3
Hg19::chr15:42697065..42697078,+	p8@CAPN3
Hg19::chr15:56649336..56649342,+	p@chr15:56649336..56649342 +
Hg19::chr15:77861183..77861202,+	p2@ENST00000560590 p2@ENST00000561123
Hg19::chr15:81474930..81474948,+	p9@IL16
Hg19::chr15:93221398..93221407,-	p@chr15:93221398..93221407 -
Hg19::chr15:93221436..93221457,-	p@chr15:93221436..93221457 -
Hg19::chr16:1521954..1521959,-	p@chr16:1521954..1521959 -
Hg19::chr16:27730289..27730294,+	p@chr16:27730289..27730294 +
Hg19::chr16:27730402..27730415,+	p@chr16:27730402..27730415 +
Hg19::chr16:27771451..27771455,+	p@chr16:27771451..27771455 +
Hg19::chr16:68678809..68678833,+	p5@CDH3
Hg19::chr16:68678836..68678860,+	p4@CDH3
Hg19::chr16:68678879..68678886,+	p10@CDH3
Hg19::chr16:68678892..68678897,+	p12@CDH3
Hg19::chr16:68678900..68678907,+	p11@CDH3
Hg19::chr16:68678922..68678943,+	p6@CDH3
Hg19::chr16:68678959..68679004,+	p7@CDH3
Hg19::chr16:68680075..68680109,-	p@chr16:68680075..68680109 -
Hg19::chr16:84074735..84074743,+	p@chr16:84074735..84074743 +
Hg19::chr16:89985263..89985286,+	p1@ENST00000540694
Hg19::chr16:89986242..89986250,+	p@chr16:89986242..89986250 +
Hg19::chr16:89986251..89986268,+	p@chr16:89986251..89986268 +
Hg19::chr17:30850461..30850471,-	p@chr17:30850461..30850471 -
Hg19::chr17:505227..505267,-	p@chr17:505227..505267 -
Hg19::chr17:75316266..75316279,+	p33@SEPT9
Hg19::chr17:75316336..75316406,+	p5@SEPT9
Hg19::chr17:77923564..77923575,-	p@chr17:77923564..77923575 -
Hg19::chr17:77923585..77923600,-	p@chr17:77923585..77923600 -
Hg19::chr17:77924634..77924661,-	p2@TBC1D16
Hg19::chr17:77924675..77924686,-	p3@TBC1D16
Hg19::chr17:77924692..77924709,-	p4@TBC1D16
Hg19::chr17:77925754..77925770,-	p@chr17:77925754..77925770 -
Hg19::chr17:77925806..77925817,-	p@chr17:77925806..77925817 -
Hg19::chr17:77925869..77925876,-	p@chr17:77925869..77925876 -
Hg19::chr18:20715441..20715457,+	p1@CABLES1
Hg19::chr18:67872552..67872584,-	p@chr18:67872552..67872584 -
Hg19::chr18:67872703..67872710,-	p@chr18:67872703..67872710 -
Hg19::chr18:74845949..74845955,-	p47@MBP
Hg19::chr19:1168968..1168981,-	p@chr19:1168968..1168981 -
Hg19::chr19:15235947..15235958,-	p5@ILVBL
Hg19::chr19:15235970..15236010,-	p3@ILVBL
Hg19::chr19:19569270..19569277,+	p32@GATAD2A
Hg19::chr19:29374467..29374501,+	p@chr19:29374467..29374501 +
Hg19::chr19:3544396..3544409,-	p@chr19:3544396..3544409 -
Hg19::chr19:3544594..3544603,-	p@chr19:3544594..3544603 -
Hg19::chr19:3544629..3544640,-	p@chr19:3544629..3544640 -
Hg19::chr19:3546150..3546160,-	p@chr19:3546150..3546160 -
Hg19::chr19:3546308..3546322,-	p@chr19:3546308..3546322 -
Hg19::chr19:3547305..3547318,-	p@chr19:3547305..3547318 -
Hg19::chr19:3547534..3547553,-	p@chr19:3547534..3547553 -
Hg19::chr19:3547903..3547940,-	p@chr19:3547903..3547940 -
Hg19::chr19:3547999..3548008,-	p@chr19:3547999..3548008 -
Hg19::chr19:3551058..3551077,-	p@chr19:3551058..3551077 -
Hg19::chr19:3551104..3551146,-	p@chr19:3551104..3551146 -
Hg19::chr19:3551160..3551196,-	p@chr19:3551160..3551196 -
Hg19::chr19:3553724..3553727,-	p@chr19:3553724..3553727 -
Hg19::chr19:3554540..3554542,-	p@chr19:3554540..3554542 -
Hg19::chr19:3557499..3557510,-	p3@MFSD12
Hg19::chr19:3557570..3557590,-	p1@MFSD12
Hg19::chr19:3557606..3557617,-	p2@MFSD12
Hg19::chr19:3557773..3557778,-	p13@MFSD12
Hg19::chr19:3557800..3557811,-	p9@MFSD12
Hg19::chr19:3557823..3557843,-	p5@MFSD12
Hg19::chr19:3557867..3557877,-	p7@MFSD12
Hg19::chr19:3557918..3557927,-	p8@MFSD12
Hg19::chr19:3557930..3557939,-	p12@MFSD12
Hg19::chr19:3557974..3557985,-	p11@MFSD12
Hg19::chr19:3557989..3557998,-	p10@MFSD12
Hg19::chr19:3558028..3558043,-	p6@MFSD12
Hg19::chr19:3558051..3558082,-	p4@MFSD12
Hg19::chr19:3558086..3558102,-	p@chr19:3558086..3558102 -
Hg19::chr19:3572689..3572697,+	p22@HMG20B
Hg19::chr19:3572758..3572795,+	p7@HMG20B
Hg19::chr19:3572925..3573014,+	p1@HMG20B
Hg19::chr19:3573783..3573829,-	p@chr19:3573783..3573829 -
Hg19::chr19:3574157..3574180,+	p4@HMG20B
Hg19::chr19:3574330..3574393,+	p2@HMG20B
Hg19::chr19:3574400..3574430,+	p6@HMG20B
Hg19::chr19:3574468..3574478,+	p19@HMG20B
Hg19::chr1:1497446..1497455,-	p4@AK129493
Hg19::chr1:1497497..1497523,-	p1@AK129493
Hg19::chr1:1497528..1497559,-	p2@AK129493
Hg19::chr1:1497566..1497576,-	p3@AK129493
Hg19::chr1:1535369..1535429,-	p2@LOC643988
Hg19::chr1:1535455..1535568,-	p1@LOC643988
Hg19::chr1:154401791..154401807,+	p11@IL6R
Hg19::chr1:16007955..16007970,+	p@chr1:16007955..16007970 +
Hg19::chr1:16007974..16007985,+	p@chr1:16007974..16007985 +
Hg19::chr1:16007995..16008026,+	p@chr1:16007995..16008026 +
Hg19::chr1:161676969..161676980,+	p5@FCRLA
Hg19::chr1:161676983..161676994,+	p3@FCRLA
Hg19::chr1:207083151..207083160,-	p14@FAIM3
Hg19::chr1:207083172..207083189,-	p8@FAIM3
Hg19::chr1:207083199..207083262,-	p3@FAIM3
Hg19::chr1:207083310..207083326,-	p6@FAIM3
Hg19::chr1:207083343..207083348,-	p19@FAIM3
Hg19::chr1:207083660..207083669,-	p20@FAIM3
Hg19::chr1:216221933..216221937,-	p@chr1:216221933..216221937 -
Hg19::chr1:236035593..236035595,-	p@chr1:236035593..236035595 -
Hg19::chr1:236046760..236046770,-	p13@LYST
Hg19::chr1:2488970..2488979,+	p21@TNFRSF14
Hg19::chr1:2488990..2488993,+	p29@TNFRSF14
Hg19::chr1:2489069..2489079,+	p20@TNFRSF14
Hg19::chr1:32705788..32705829,-	p2@MTMR9LP
Hg19::chr1:64104373..64104382,+	p@chr1:64104373..64104382 +
Hg19::chr1:64104401..64104429,+	p@chr1:64104401..64104429 +
Hg19::chr20:55091919..55091934,+	p1@FAM209A
Hg19::chr20:55091968..55091976,+	p6@FAM209A
Hg19::chr21:38568192..38568213,+	p@chr21:38568192..38568213 +
Hg19::chr21:38568227..38568233,+	p@chr21:38568227..38568233 +
Hg19::chr22:19939035..19939049,+	p21@COMT
Hg19::chr22:19939060..19939090,+	p10@COMT
Hg19::chr22:20877924..20877934,+	p39@MED15
Hg19::chr22:20877995..20878006,+	p40@MED15
Hg19::chr22:20878024..20878053,+	p16@MED15
Hg19::chr22:20878077..20878083,+	p47@MED15
Hg19::chr22:20878094..20878105,+	p41@MED15
Hg19::chr22:26899907..26899914,-	p@chr22:26899907..26899914 -
Hg19::chr22:47377231..47377232,-	p@chr22:47377231..47377232 -
Hg19::chr2:10559858..10559877,+	p3@HPCAL1
Hg19::chr2:11752379..11752396,+	p5@GREB1
Hg19::chr2:128400745..128400763,-	p23@LIMS2
Hg19::chr2:128400774..128400781,-	p51@LIMS2
Hg19::chr2:128400788..128400798,-	p44@LIMS2
Hg19::chr2:128400821..128400830,-	p39@LIMS2
Hg19::chr2:163099546..163099567,-	p4@FAP
Hg19::chr2:202285267..202285291,-	p3@TRAK2
Hg19::chr2:232086654..232086692,+	p@chr2:232086654..232086692 +
Hg19::chr2:238395042..238395061,+	p2@MLPH
Hg19::chr2:240116933..240116969,-	p1@MGC16025
Hg19::chr2:242350325..242350332,+	p8@FARP2
Hg19::chr2:242350337..242350369,+	p3@FARP2
Hg19::chr2:65216118..65216131,+	p7@SLC1A4
Hg19::chr2:65216141..65216162,+	p9@SLC1A4
Hg19::chr2:65216462..65216567,+	p1@SLC1A4
Hg19::chr3:132136879..132136891,+	p@chr3:132136879..132136891 +
Hg19::chr3:48601207..48601222,-	p1@UCN2
Hg19::chr3:69951861..69951868,+	p@chr3:69951861..69951868 +
Hg19::chr3:69987438..69987455,+	p@chr3:69987438..69987455 +
Hg19::chr5:159894757..159894771,+	p4@uc003lyl.3
Hg19::chr5:159894797..159894808,+	p9@uc003lyl.3
Hg19::chr5:159894810..159894819,+	p12@uc003lyl.3
Hg19::chr5:159894828..159894839,+	p6@uc003lyl.3
Hg19::chr5:159894844..159894853,+	p10@uc003lyl.3
Hg19::chr5:159894864..159894881,+	p5@uc003lyl.3
Hg19::chr5:159894905..159894938,+	p2@uc003lyl.3
Hg19::chr5:159894950..159894958,+	p8@uc003lyl.3
Hg19::chr5:159895000..159895003,+	p7@uc003lyl.3
Hg19::chr5:159895082..159895093,+	p11@uc003lyl.3
Hg19::chr5:159896855..159896863,+	p@chr5:159896855..159896863 +
Hg19::chr5:159904569..159904581,-	p@chr5:159904569..159904581 -
Hg19::chr5:39462314..39462332,-	p15@DAB2
Hg19::chr5:79421543..79421571,-	p@chr5:79421543..79421571 -
Hg19::chr6:10435032..10435061,-	p1@LINC00518
Hg19::chr6:132834443..132834454,-	p6@STX7
Hg19::chr6:16238880..16238915,+	p2@GMPR
Hg19::chr6:9251842..9251865,+	p@chr6:9251842..9251865 +
Hg19::chr7:150775279..150775302,-	p@chr7:150775279..150775302 -
Hg19::chr7:20685431..20685438,+	p@chr7:20685431..20685438 +
Hg19::chr7:2692208..2692218,+	p51@TTYH3
Hg19::chr7:2692417..2692437,+	p3@TTYH3
Hg19::chr7:2692544..2692555,+	p17@TTYH3
Hg19::chr7:2701678..2701748,+	p7@TTYH3
Hg19::chr7:2701975..2702006,+	p18@TTYH3
Hg19::chr7:2702100..2702127,+	p20@TTYH3
Hg19::chr7:4008614..4008625,-	p@chr7:4008614..4008625 -
Hg19::chr7:43832250..43832263,+	p@chr7:43832250..43832263 +
Hg19::chr7:47443023..47443044,-	p16@TNS3
Hg19::chr8:12668962..12668969,-	p2@ENST00000534827
Hg19::chr8:12669036..12669054,-	p1@ENST00000534827
Hg19::chr8:20111065..20111086,-	p@chr8:20111065..20111086 -
Hg19::chr8:20111535..20111554,-	p@chr8:20111535..20111554 -
Hg19::chr8:29605604..29605613,-	p4@C8orf75
Hg19::chr8:29605633..29605652,-	p2@C8orf75
Hg19::chr8:41467069..41467095,+	p@chr8:41467069..41467095 +
Hg19::chr8:72870195..72870205,+	p@chr8:72870195..72870205 +
Hg19::chr9:12694022..12694033,+	p15@TYRP1
Hg19::chr9:12709145..12709150,+	p@chr9:12709145..12709150 +
Hg19::chr9:134406030..134406042,-	p@chr9:134406030..134406042 -
Hg19::chr9:82185685..82185693,+	p@chr9:82185685..82185693 +
Hg19::chrX:54522195..54522218,-	p5@FGD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005886	plasma membrane	0.0034475627203576
GO:0045009	chitosome	0.00438051250148185
GO:0033162	melanosome membrane	0.00438051250148185
GO:0005737	cytoplasm	0.0147934230677054
GO:0048770	pigment granule	0.0147934230677054
GO:0042470	melanosome	0.0147934230677054
GO:0044459	plasma membrane part	0.0314164411585982
GO:0046148	pigment biosynthetic process	0.0389661244552435
GO:0044425	membrane part	0.0389661244552435
GO:0005515	protein binding	0.0389661244552435
GO:0030027	lamellipodium	0.0389661244552435
GO:0035173	histone kinase activity	0.0389661244552435
GO:0005395	eye pigment precursor transporter activity	0.0389661244552435
GO:0015173	aromatic amino acid transmembrane transporter activity	0.0389661244552435
GO:0005302	L-tyrosine transmembrane transporter activity	0.0389661244552435
GO:0005896	interleukin-6 receptor complex	0.0389661244552435
GO:0016206	catechol O-methyltransferase activity	0.0389661244552435
GO:0042440	pigment metabolic process	0.0389661244552435
GO:0016020	membrane	0.0389661244552435
GO:0031410	cytoplasmic vesicle	0.0441059691015092
GO:0031982	vesicle	0.0441059691015092
GO:0019748	secondary metabolic process	0.0441059691015092
GO:0008509	anion transmembrane transporter activity	0.0441059691015092
GO:0019981	interleukin-6 binding	0.0441059691015092
GO:0015746	citrate transport	0.0441059691015092
GO:0051302	regulation of cell division	0.0441059691015092
GO:0006842	tricarboxylic acid transport	0.0441059691015092
GO:0015137	citrate transmembrane transporter activity	0.0441059691015092
GO:0043209	myelin sheath	0.0441059691015092
GO:0004915	interleukin-6 receptor activity	0.0441059691015092
GO:0015105	arsenite transmembrane transporter activity	0.0441059691015092
GO:0004371	glycerone kinase activity	0.0441059691015092
GO:0015142	tricarboxylic acid transmembrane transporter activity	0.0441059691015092
GO:0015171	amino acid transmembrane transporter activity	0.0481266501877381

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	8.82e-09	180
pigment cell	7.17e-07	14

Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	2.50e-17	659
organ	6.71e-17	511
anatomical system	1.17e-14	625
anatomical group	2.61e-14	626
embryo	1.28e-12	612
neural tube	1.43e-11	57
neural rod	1.43e-11	57
future spinal cord	1.43e-11	57
neural keel	1.43e-11	57
embryonic structure	1.83e-11	605
developing anatomical structure	1.83e-11	605
anatomical cluster	2.40e-11	286
germ layer	2.74e-11	604
embryonic tissue	2.74e-11	604
presumptive structure	2.74e-11	604
epiblast (generic)	2.74e-11	604
organ part	4.65e-11	219
organism subdivision	5.03e-11	365
neural plate	1.81e-10	86
presumptive neural plate	1.81e-10	86
epithelium	2.97e-10	309
gray matter	3.23e-10	34
brain grey matter	3.23e-10	34
telencephalon	3.32e-10	34
cell layer	8.24e-10	312
regional part of telencephalon	9.36e-10	33
regional part of brain	1.10e-09	59
neurectoderm	1.26e-09	90
cerebral hemisphere	3.35e-09	32
anterior neural tube	3.99e-09	42
regional part of forebrain	4.23e-09	41
forebrain	4.23e-09	41
future forebrain	4.23e-09	41
tube	4.97e-09	194
pre-chordal neural plate	9.24e-09	61
anatomical conduit	1.55e-08	241
adult organism	3.54e-08	115
central nervous system	4.19e-08	82
brain	4.58e-08	69
future brain	4.58e-08	69
regional part of nervous system	1.88e-07	94
nervous system	1.88e-07	94
head	2.46e-07	123
regional part of cerebral cortex	2.94e-07	22
multi-tissue structure	3.91e-07	347
larynx	4.31e-07	9
cerebral cortex	5.41e-07	25
pallium	5.41e-07	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BCL11A#53335	15	1.98851320819676	0.00940956792991135	0.0355018194802215
BHLHE40#8553	11	2.30649508886333	0.00910975007435419	0.0344714923194013
BRF2#55290	3	15.0641436644208	0.00110426921224957	0.00767579183082412
GATA2#2624	27	1.60800540563532	0.0100166355359509	0.0375575284964162
PRDM1#639	12	7.39239004359593	1.19925028668985e-07	6.91216891234003e-06
STAT1#6772	22	2.1287146025158	0.00075455913225001	0.00593414165760985

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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