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Coexpression cluster:C3923

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Full id: C3923_mesenchymal_Mesothelial_Fibroblast_leiomyoma_basal_mature_epithelioid



Phase1 CAGE Peaks

  Short description
Hg19::chr1:203596195..203596206,+ p5@ATP2B4
Hg19::chr1:203596211..203596216,+ p6@ATP2B4
Hg19::chr1:203596217..203596249,+ p3@ATP2B4


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm1.47e-1583
epithelial tube open at both ends4.10e-1459
blood vessel4.10e-1459
blood vasculature4.10e-1459
vascular cord4.10e-1459
vasculature1.09e-1278
vascular system1.09e-1278
vessel2.23e-1268
artery6.62e-1242
arterial blood vessel6.62e-1242
arterial system6.62e-1242
dense mesenchyme tissue1.01e-1173
epithelial vesicle1.42e-1178
muscle tissue1.84e-1164
musculature1.84e-1164
musculature of body1.84e-1164
paraxial mesoderm1.93e-1172
presumptive paraxial mesoderm1.93e-1172
systemic artery3.15e-1133
systemic arterial system3.15e-1133
somite3.25e-1171
presomitic mesoderm3.25e-1171
presumptive segmental plate3.25e-1171
dermomyotome3.25e-1171
trunk paraxial mesoderm3.25e-1171
skeletal muscle tissue4.45e-1162
striated muscle tissue4.45e-1162
myotome4.45e-1162
circulatory system4.59e-10112
multilaminar epithelium1.53e-0983
cardiovascular system2.72e-09109
aorta3.99e-0921
aortic system3.99e-0921
epithelial tube5.16e-09117
multi-cellular organism5.76e-08656
trunk mesenchyme6.49e-08122
epithelium8.96e-08306
anatomical cluster9.41e-08373
mesenchyme9.81e-08160
entire embryonic mesenchyme9.81e-08160
cell layer1.31e-07309
unilaminar epithelium2.31e-07148
anatomical system2.75e-07624
anatomical group3.56e-07625
tube3.82e-07192
anatomical conduit8.47e-07240


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.12.4146
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.13.5636
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.13.33427
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.62945
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.12.37721
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.26.90173
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.0115262814102908
ELF1#199734.258097958807540.01295179875054610.0462578794100364
EP300#203336.77394172622320.003216880500103790.0167573336600499
GTF2F1#2962312.73966087675770.0004835525047438590.00434162139296285
IRF1#365937.63716375356390.002244692747297240.0128161746028306
JUN#3725312.51282919233630.0005103313992726250.00444450475388873
JUND#372736.994663941871030.002921845042734990.0156867616520948
MAFK#7975327.10073313782995.02195559325033e-050.000857987927700755
MAX#414936.452555509007120.003721913834265510.0186665846588962
MXI1#460139.96157162875930.001011470541259020.00720628773167003
MYC#460935.22228187160940.007020843755740150.0294702745470739
RAD21#5885310.35503389545630.0009004912073565420.00664357171553474
RFX5#5993312.04791082719510.0005717246050312580.00484898051200743
SMARCB1#6598318.25271578115740.000164397760679890.00203189795593456
SMC3#9126315.04493284493280.0002935825420371870.00309243238606371
SP1#666735.69838137814090.005403962701712170.0246714661918219
STAT3#6774310.51946499715420.0008589184530415310.0064295143575978
WRNIP1#568973109.8199643493767.53682839543883e-073.3240659661792e-05
ZBTB7A#5134137.35190930787590.002516255860282270.0140299634718926
ZNF263#1012738.221841637010680.001799043925565870.0109480450146938



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.