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Coexpression cluster:C2369

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Full id: C2369_CD14CD16_Natural_CD8_CD14_Basophils_CD4_Whole



Phase1 CAGE Peaks

Hg19::chr16:30484054..30484084,+p1@ITGAL
Hg19::chr8:21771173..21771178,-p2@DOK2
Hg19::chr8:21771182..21771208,-p1@DOK2
Hg19::chr8:21771214..21771223,-p4@DOK2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005069transmembrane receptor protein tyrosine kinase docking protein activity0.00847732021019322
GO:0005066transmembrane receptor protein tyrosine kinase signaling protein activity0.012714857326154
GO:0005158insulin receptor binding0.021657885290216
GO:0008305integrin complex0.038793191786861
GO:0007229integrin-mediated signaling pathway0.038793191786861
GO:0007166cell surface receptor linked signal transduction0.038793191786861
GO:0032403protein complex binding0.038793191786861
GO:0043235receptor complex0.038793191786861
GO:0005057receptor signaling protein activity0.0493003668503964
GO:0004871signal transducer activity0.0493003668503964
GO:0060089molecular transducer activity0.0493003668503964
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0493003668503964



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell7.65e-79172
angioblastic mesenchymal cell7.65e-79172
hematopoietic oligopotent progenitor cell1.94e-74165
hematopoietic multipotent progenitor cell1.94e-74165
hematopoietic cell9.46e-74182
leukocyte1.82e-66140
nongranular leukocyte3.99e-56119
hematopoietic lineage restricted progenitor cell4.24e-56124
myeloid cell6.07e-47112
common myeloid progenitor6.07e-47112
myeloid leukocyte1.95e-3576
granulocyte monocyte progenitor cell2.11e-3171
myeloid lineage restricted progenitor cell8.20e-3170
macrophage dendritic cell progenitor1.16e-2965
monopoietic cell3.82e-2963
monocyte3.82e-2963
monoblast3.82e-2963
promonocyte3.82e-2963
CD14-positive, CD16-negative classical monocyte2.13e-2642
classical monocyte7.82e-2445
lymphocyte5.37e-2353
common lymphoid progenitor5.37e-2353
lymphoid lineage restricted progenitor cell8.85e-2352
T cell9.75e-1625
pro-T cell9.75e-1625
mesenchymal cell1.23e-14358
mature alpha-beta T cell1.69e-1318
alpha-beta T cell1.69e-1318
immature T cell1.69e-1318
mature T cell1.69e-1318
immature alpha-beta T cell1.69e-1318
connective tissue cell1.73e-13365
motile cell1.05e-09390
CD8-positive, alpha-beta T cell4.09e-0911
intermediate monocyte2.25e-089
CD14-positive, CD16-positive monocyte2.25e-089
lymphocyte of B lineage5.83e-0724
pro-B cell5.83e-0724
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.30e-41102
blood island8.30e-41102
hemolymphoid system3.51e-36112
bone marrow1.20e-2780
bone element4.48e-2486
immune system3.69e-22115
adult organism2.01e-17115
skeletal element3.61e-17101
skeletal system3.61e-17101
connective tissue4.94e-12375
lateral plate mesoderm2.39e-10216
blood2.49e-1015
haemolymphatic fluid2.49e-1015
organism substance2.49e-1015
Disease
Ontology termp-valuen
hematologic cancer1.70e-1351
immune system cancer1.70e-1351
leukemia1.82e-1239
myeloid leukemia1.41e-1031


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MEF2A#4205418.74323090964418.0978922767748e-060.000224392616474949
SPI1#668848.204323508522730.000220661881527680.00249385415483924
TAF1#687243.343046285745290.008005664898701650.0321850656846371
TBP#690843.706770687096390.005296377814784350.0243914102918363
ZEB1#6935312.66632401315790.000793336075912850.00613151975373804



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.