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Coexpression cluster:C2537: Difference between revisions

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|full_id=C2537_uterus_occipital_cervix_rectum_mesothelioma_Cardiac_parietal
|full_id=C2537_uterus_occipital_cervix_rectum_mesothelioma_Cardiac_parietal
|id=C2537
|id=C2537
|ontology_enrichment_celltype=CL:0000055!6.03e-07!180
|ontology_enrichment_celltype=
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0005743!1.08e-24!86;UBERON:0001017!2.28e-24!82;UBERON:0000073!4.56e-24!94;UBERON:0001016!4.56e-24!94;UBERON:0007023!1.17e-22!115;UBERON:0002346!1.06e-21!90;UBERON:0003075!1.80e-20!86;UBERON:0007284!1.80e-20!86;UBERON:0000924!9.98e-19!173;UBERON:0006601!9.98e-19!173;UBERON:0000955!2.05e-18!69;UBERON:0006238!2.05e-18!69;UBERON:0001049!7.88e-18!57;UBERON:0005068!7.88e-18!57;UBERON:0006241!7.88e-18!57;UBERON:0007135!7.88e-18!57;UBERON:0004121!1.28e-17!169;UBERON:0000481!2.71e-17!347;UBERON:0000475!3.03e-17!365;UBERON:0002616!5.22e-17!59;UBERON:0000468!1.10e-15!659;UBERON:0003056!2.68e-15!61;UBERON:0000033!3.21e-14!123;UBERON:0000153!3.48e-14!129;UBERON:0007811!3.48e-14!129;UBERON:0003080!3.98e-14!42;UBERON:0002780!7.77e-14!41;UBERON:0001890!7.77e-14!41;UBERON:0006240!7.77e-14!41;UBERON:0000477!2.81e-13!286;UBERON:0001893!4.95e-13!34;UBERON:0001869!5.98e-13!32;UBERON:0000119!8.20e-13!312;UBERON:0000483!1.31e-12!309;UBERON:0002791!1.32e-12!33;UBERON:0002020!1.36e-12!34;UBERON:0003528!1.36e-12!34;UBERON:0000956!2.64e-11!25;UBERON:0000203!2.64e-11!25;UBERON:0000064!2.98e-11!219;UBERON:0000922!4.73e-11!612;UBERON:0004111!1.82e-10!241;UBERON:0000062!1.94e-10!511;UBERON:0000467!3.96e-10!625;UBERON:0000480!4.53e-10!626;UBERON:0002619!6.15e-10!22;UBERON:0000025!1.50e-09!194;UBERON:0001950!2.77e-09!20;UBERON:0002050!7.41e-09!605;UBERON:0005423!7.41e-09!605;UBERON:0000923!1.59e-08!604;UBERON:0005291!1.59e-08!604;UBERON:0006598!1.59e-08!604;UBERON:0002532!1.59e-08!604
|ontology_enrichment_uberon=UBERON:0001017!3.76e-24!81;UBERON:0002346!8.86e-24!86;UBERON:0001016!9.89e-24!89;UBERON:0011216!4.49e-23!223;UBERON:0003075!2.34e-22!82;UBERON:0007284!2.34e-22!82;UBERON:0000477!1.29e-20!373;UBERON:0004121!3.48e-20!171;UBERON:0000924!3.48e-20!171;UBERON:0006601!3.48e-20!171;UBERON:0007023!2.25e-19!114;UBERON:0010314!7.33e-19!132;UBERON:0001049!4.69e-18!56;UBERON:0005068!4.69e-18!56;UBERON:0006241!4.69e-18!56;UBERON:0007135!4.69e-18!56;UBERON:0000955!9.99e-18!68;UBERON:0006238!9.99e-18!68;UBERON:0003056!7.92e-17!61;UBERON:0000073!9.75e-17!53;UBERON:0002616!9.75e-17!53;UBERON:0000481!9.85e-17!342;UBERON:0010371!4.10e-16!104;UBERON:0002780!1.34e-14!41;UBERON:0001890!1.34e-14!41;UBERON:0003080!1.34e-14!41;UBERON:0006240!1.34e-14!41;UBERON:0001893!4.74e-14!34;UBERON:0001869!9.85e-14!32;UBERON:0003528!2.11e-13!34;UBERON:0002020!2.11e-13!34;UBERON:0002791!3.48e-13!32;UBERON:0000468!3.90e-13!656;UBERON:0000956!9.08e-13!25;UBERON:0000203!9.08e-13!25;UBERON:0000119!6.11e-12!309;UBERON:0000483!1.09e-11!306;UBERON:0002619!3.03e-11!22;UBERON:0000062!7.01e-11!503;UBERON:0000064!8.24e-11!218;UBERON:0001950!1.56e-10!20;UBERON:0000922!2.72e-10!592;UBERON:0000923!6.48e-10!560;UBERON:0010316!6.48e-10!560;UBERON:0005291!6.48e-10!560;UBERON:0006598!6.48e-10!560;UBERON:0010317!6.48e-10!560;UBERON:0002532!6.48e-10!560;UBERON:0002050!8.10e-10!564;UBERON:0005423!1.21e-08!581;UBERON:0004111!4.15e-08!240;UBERON:0000467!8.53e-08!624;UBERON:0000480!1.17e-07!625;UBERON:0000025!1.25e-07!192
|tf_chipseq_enrich=FOXA1#3169;3:8.31106481203909:0.00274013818210985:0.0150374279649714
|tf_chipseq_enrich=FOXA1#3169;3:8.31106481203909:0.00274013818210985:0.0150374279649714
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}}
}}

Revision as of 14:08, 19 October 2012


Full id: C2537_uterus_occipital_cervix_rectum_mesothelioma_Cardiac_parietal



Phase1 CAGE Peaks

Hg19::chr1:164528911..164528940,+p7@PBX1
Hg19::chr1:164528942..164528964,+p11@PBX1
Hg19::chr1:164528975..164528998,+p13@PBX1
Hg19::chr1:164529004..164529015,+p15@PBX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
central nervous system3.76e-2481
neurectoderm8.86e-2486
nervous system9.89e-2489
organ system subdivision4.49e-23223
neural plate2.34e-2282
presumptive neural plate2.34e-2282
anatomical cluster1.29e-20373
ectoderm-derived structure3.48e-20171
ectoderm3.48e-20171
presumptive ectoderm3.48e-20171
adult organism2.25e-19114
structure with developmental contribution from neural crest7.33e-19132
neural tube4.69e-1856
neural rod4.69e-1856
future spinal cord4.69e-1856
neural keel4.69e-1856
brain9.99e-1868
future brain9.99e-1868
pre-chordal neural plate7.92e-1761
regional part of nervous system9.75e-1753
regional part of brain9.75e-1753
multi-tissue structure9.85e-17342
ecto-epithelium4.10e-16104
regional part of forebrain1.34e-1441
forebrain1.34e-1441
anterior neural tube1.34e-1441
future forebrain1.34e-1441
telencephalon4.74e-1434
cerebral hemisphere9.85e-1432
brain grey matter2.11e-1334
gray matter2.11e-1334
regional part of telencephalon3.48e-1332
multi-cellular organism3.90e-13656
cerebral cortex9.08e-1325
pallium9.08e-1325
cell layer6.11e-12309
epithelium1.09e-11306
regional part of cerebral cortex3.03e-1122
organ7.01e-11503
organ part8.24e-11218
neocortex1.56e-1020
embryo2.72e-10592
germ layer6.48e-10560
germ layer / neural crest6.48e-10560
embryonic tissue6.48e-10560
presumptive structure6.48e-10560
germ layer / neural crest derived structure6.48e-10560
epiblast (generic)6.48e-10560
embryonic structure8.10e-10564
developing anatomical structure1.21e-08581
anatomical conduit4.15e-08240
anatomical system8.53e-08624
anatomical group1.17e-07625
tube1.25e-07192


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA1#316938.311064812039090.002740138182109850.0150374279649714



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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