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{{Coexpression_clusters
{
|full_id=C2536_cervix_occipital_breast_parietal_uterus_smooth_temporal

Latest revision as of 12:07, 17 September 2013


Full id: C2536_cervix_occipital_breast_parietal_uterus_smooth_temporal



Phase1 CAGE Peaks

Hg19::chr1:164528340..164528379,+p4@PBX1
Hg19::chr1:164528384..164528409,+p3@PBX1
Hg19::chr1:164528410..164528428,+p1@PBX1
Hg19::chr1:164528445..164528459,+p2@PBX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism3.18e-37114
organ system subdivision4.85e-26223
central nervous system3.48e-2581
nervous system2.13e-2389
anatomical cluster3.30e-23373
multi-tissue structure2.49e-22342
brain3.75e-2168
future brain3.75e-2168
ectoderm-derived structure4.04e-21171
ectoderm4.04e-21171
presumptive ectoderm4.04e-21171
neurectoderm6.03e-2186
neural plate9.00e-2182
presumptive neural plate9.00e-2182
neural tube1.11e-2056
neural rod1.11e-2056
future spinal cord1.11e-2056
neural keel1.11e-2056
regional part of nervous system1.47e-1953
regional part of brain1.47e-1953
regional part of forebrain3.08e-1841
forebrain3.08e-1841
anterior neural tube3.08e-1841
future forebrain3.08e-1841
structure with developmental contribution from neural crest6.57e-18132
multi-cellular organism3.04e-17656
pre-chordal neural plate9.92e-1761
telencephalon2.38e-1634
cerebral hemisphere4.63e-1632
brain grey matter1.11e-1534
gray matter1.11e-1534
regional part of telencephalon1.56e-1532
ecto-epithelium9.76e-15104
organ part1.22e-14218
cerebral cortex4.75e-1425
pallium4.75e-1425
regional part of cerebral cortex1.57e-1322
neocortex1.01e-1220
germ layer6.22e-12560
germ layer / neural crest6.22e-12560
embryonic tissue6.22e-12560
presumptive structure6.22e-12560
germ layer / neural crest derived structure6.22e-12560
epiblast (generic)6.22e-12560
anatomical group6.72e-12625
anatomical conduit7.03e-12240
anatomical system8.90e-12624
embryonic structure1.36e-11564
cell layer1.89e-11309
organ2.04e-11503
epithelium2.78e-11306
embryo1.36e-10592
developing anatomical structure2.98e-10581
tube3.17e-10192
subdivision of digestive tract8.25e-07118


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.720743
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.12.45009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.12.70115
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.98562
MA0115.11.45393
MA0116.10.457606
MA0117.12.78257
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.21.83323
MA0039.21.5472
MA0138.20.928035
MA0002.22.63392
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.25.94823
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.11.37853
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.231.8079
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.00268178406597281
GATA2#2624412.7449317335543.78864877853583e-050.000722048703980846
GTF2F1#2962412.73966087675773.79492332235515e-050.000718524287279641
IRF1#365947.63716375356390.0002938853996185490.00307638541152266
MXI1#460149.96157162875930.0001015224754950450.00142435596698374
NFYA#4800418.42558069983058.67100748407158e-060.000234487661996104
NFYB#4801416.75979325353651.26678572070404e-050.000311444995020267
PBX3#5090421.91451268674414.33289161192893e-060.000136466485843862
RAD21#5885410.35503389545638.6948481184721e-050.00129430051688299
SP2#6668426.15353049384462.13562021071447e-067.74720525136537e-05
TAF1#687243.343046285745290.008005664898701650.0322384282381146
TAF7#687938.574802053692940.00250055433515240.0140353304782599
TBP#690843.706770687096390.005296377814784350.0244355878693406
ZNF263#1012748.221841637010680.0002187871180958320.00248963911819684



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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