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Coexpression cluster:C2545: Difference between revisions

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|tf_chipseq_enrich=CCNT2#905;4:6.33620157696263:0.000620310058721564:0.00512373949879955!E2F1#1869;4:4.90738921487932:0.00172402235736179:0.0106516310329217!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101480167292247!MYC#4609;4:5.2222818716094:0.00134430939527274:0.00887978805470175!RAD21#5885;4:10.3550338954563:8.6948481184721e-05:0.0012944850215896!ZBTB7A#51341;4:7.3519093078759:0.00034222354001599:0.00346735392857295!ZNF263#10127;4:8.22184163701068:0.000218787118095832:0.00248991040937241
|tf_chipseq_enrich=CCNT2#905;4:6.33620157696263:0.000620310058721564:0.00512373949879955!E2F1#1869;4:4.90738921487932:0.00172402235736179:0.0106516310329217!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101480167292247!MYC#4609;4:5.2222818716094:0.00134430939527274:0.00887978805470175!RAD21#5885;4:10.3550338954563:8.6948481184721e-05:0.0012944850215896!ZBTB7A#51341;4:7.3519093078759:0.00034222354001599:0.00346735392857295!ZNF263#10127;4:8.22184163701068:0.000218787118095832:0.00248991040937241
|tfbs_overrepresentation=0.191353,0.0774498,0.0285313,0.0631091,0.257053,0.363996,0.0569281,0.00615604,0.043387,0.0341265,0.181435,2.87481e-05,0.243414,0.164339,0.193153,0.0816702,0.183412,0.128744,0.0698403,0.141416,0.243245,0.172742,0.107781,0.124486,0.0550418,1.20948e-06,0.268949,0.119094,0.186914,0.122514,0.00379621,0.149094,0.0239693,0.267529,0.0877018,0.111013,0.000214462,0.0568767,0.157159,0.0879352,0.126525,0.0326801,0.182216,0.2375,0.157881,0.0480278,0.0503649,0.234372,0.145553,0.158244,0.19996,0.0715789,0.0924421,0.12203,0.255843,0.0508907,0.140644,0.273035,0.103044,0.138225,0.0390464,0.194086,0.142115,0.0999599,0.0720888,0.0667453,0.00296141,0.0792005,0.113084,0.216289,0.00050917,0.0892037,0.116917,0.155921,0.00995563,0.0227583,0.126543,0.0578308,0.0493551,0.00965832,0.125428,0.000439738,0.0562614,0.150119,0.0780785,0.000686125,0.0848546,0.268505,3.9269e-14,0.0827752,0.112676,0.0655645,0.12511,0.0626609,0.112199,0.150351,4.78277e-09,0.0213527,0.121709,0.0689843,0.0759036,0.350158,0.184542,0.0491142,0.280878,0.0541957,0.0883058,0.423154,0.0187949,0.000915719,0.23573,0.0450707,0.194256,0.0235108,0.132631,0.0447483,0.0270258,0.0748174,0.180926,0.110194,0.215858,0.275495,0.182323,0.112709,0.134107,0.0283927,0.119051,0.0196757,0.110868,0.016435,0.078637,0.0985137,0.0755515,0.0302655,0.164103,0.141472,0.085537,0.0730922,0.0438087,0.0052702,0.0302521,0.166414,0.262198,0.202388,6.21805e-07,0.0913381,0.129544,0.110696,0.0515825,0.157774,0.258146,0.186826,0.233377,0.0352845,0.0565357,0.153577,0.0984158,0.29227,0.0683304,0.0447121,0.291455,0.124982,0.152417,0.00137816,8.68159e-10,0.149398,0.0530169,0.166112,0.0534404,0.392741,0.2321,0.179282,2.04764e-08,0.0715212,0.105131,0.118265,0.0177884,0.234755,0.230552,0.0472274,0.205973,0.159869,0.0363736,0.15105,0.0970713,0.155237,0.236268,0.0532055,0.108938,0.224443,0.140245,0.000195464,0.160458,0.292792,1.98661e-08,0.0622664,0.102951,0.00325254,0.0891668,2.11932e-05,0.117261,0.0797088,0.0408965,0.0799774,0.177664,0.329956,0.0094037,0.197158,0.00387451,0.00246422,0.0606832,0.136664,0.158184,0.147626,0.393313,0.218801,0.21271,0.132273,0.0830988,0.134907,0.184613,0.462724,0.202467,0.208718,0.0972471,0.165147,0.180711,0.112956,0.0797807,0.0790532,1.55144e-12,0.137848,0.0553945,0.10068,0.00826774,0.122288,0.0624687,0.334388,0.21183,0.275612,0.235571,0.00284082,0.128998,0.109226,0.151958,0.178155,0.107176,2.28065e-05,0.003812,0.15291,0.206234,0.238926,0.239646,0.128521,0.1286,0.207017,0.14037,0.259646,0.0916845,0.0307561,0.0816983,0.226367,0.0241753,0.000887749,0.0457509,0.106603,0.106727,0.12083,0.154253,0.0993998,0.00993324,0.0834863,0.324356,0.0458938,0.113754,0.0504034,0.169684,0.000218453,0.000338943,3.65688e-08,0.73998,0.100371,0.000670052,3.59158e-14,0.420045,0.00044921,0.332539,0.0457383,0.00385231,0.389374,0.00236126,0.414547,0.000655012,0.017023,0.020249,0.364388,0.34505,0.369161,0.00558459,0.49089,0.687176,0.00807111,0.241524,0.45167,0.0299727,0.520726,0.143893,0.41477,0.279946,0.00704767,0.467825,0.563725,0.00309806,0.632838,7.38653e-05,0.460819,0.511459,3.86765e-05,0.322903,0.350886,0.00149966,0.583749,0.398372,0.286293,0.239547,0.036653,0.0105546,0.0018021,0.000193862,0.0115272,0.547291,0.00119114,0.00630994,0.369971,0.0117353,0.00804842,0.464342,0.318915,0.714007,0.235444,1.24944e-06,1.53499e-07,3.77863e-06,0.349116,0.302142,0.239545,0.432689,0.0845186,0.067384,0.145459,0.606382,5.38824e-10,0.0774588,0.316925,0.356561,0.0552678,0.211506,0.0883859,0.0962508,0.238465,6.79252e-09,0.000844682,0.0306084,0.00604019,0.0178234,0.284591,0.0235356,0.00879043,0.280307,0.393583,4.20451e-05,0.0596868,0.0984075,0.293026,2.25475e-06,0.0326188,6.22959e-07,0.372182,0.0194133,3.38892e-05,0.365653,1.4366e-06,4.93351e-06,3.96422e-07,3.5174e-06,0.172079,0.291917,0.421082,0.25441,0.202782,0.103116,0.166182,0.0124357,0.517001,0.620475,2.91706e-09,0.419676,0.188259,0.189182,0.477589,3.49013e-07,0.187849,0.560187,0.321282,0.198207,0.0616078,0.178485,0.329745,0.175552,0.129238,0.651295,0.00133237,0.360161,0.429696,0.386216,0.0861729,0.706685,0.000413361,0.259338,0.360203,0.333725,0.119902,0.289666,0.500627,0.00632745,0.452694,0.565545,1.81566e-10,0.265037,0.261923,0.0543569,0.00117039,0.341771,0.002507,3.31472e-15,0.356381,0.184395,0.55524,0.00336238,0.206945,0.304719,0.462531,0.296994,0.244339,0.117049,0.0786167,0.629381,0.00230637,0.433821,0.276604,0.436806,0.576549,0.499072,0.396083,0.00246373,0.00183829,0.0919254,0.0735469,0.248103,0.102621,0.0760107,0.187642,0.286156,0.261868,0.184029,1.66025e-06,0.0334242,0.146385,0.365815,0.0576261,0.00153351,0.164977,0.175633,0.139918,0.000975864,0.00352963,5.0158e-06,0.0238089,2.55916e-09,0.354433,0.48311,0.0614918,0.219485,0.149782,0.136923,0.118103,0.113892,0.207214,0.140201,0.0580534,0.00518407,0.161297,0.168389,0.270152,0.249506,0.432751,0.0660736,0.108971,0.0879235,0.00263193,0.145546,0.28124,0.0175667,0.251882,4.57832e-05,2.03714e-08,0.0637178,0.257309,8.62868e-05,0.166608,0.227224,0.238082,0.0259579,0.115115,0.124916,0.0149794,0.28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}}
}}

Revision as of 15:34, 26 November 2012


Full id: C2545_skeletal_Mast_Mesenchymal_stomach_lung_left_rectum



Phase1 CAGE Peaks

Hg19::chr1:184356112..184356185,+p1@C1orf21
Hg19::chr1:184356188..184356200,+p3@C1orf21
Hg19::chr1:184356231..184356262,+p2@C1orf21
Hg19::chr1:184356271..184356286,+p4@C1orf21


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.08e-30114
neural tube8.49e-2156
neural rod8.49e-2156
future spinal cord8.49e-2156
neural keel8.49e-2156
regional part of nervous system1.43e-1953
regional part of brain1.43e-1953
ectoderm-derived structure8.45e-19171
ectoderm8.45e-19171
presumptive ectoderm8.45e-19171
neural plate4.96e-1882
presumptive neural plate4.96e-1882
ecto-epithelium1.03e-17104
neurectoderm5.75e-1786
regional part of forebrain6.96e-1741
forebrain6.96e-1741
anterior neural tube6.96e-1741
future forebrain6.96e-1741
nervous system2.13e-1689
structure with developmental contribution from neural crest2.77e-16132
central nervous system2.92e-1681
brain grey matter7.69e-1634
gray matter7.69e-1634
brain7.99e-1668
future brain7.99e-1668
telencephalon1.09e-1534
cerebral hemisphere2.34e-1532
regional part of telencephalon4.60e-1532
regional part of cerebral cortex1.32e-1322
cerebral cortex5.75e-1325
pallium5.75e-1325
pre-chordal neural plate1.51e-1261
neocortex1.83e-1220
organ system subdivision5.01e-12223
anatomical cluster1.71e-11373
multi-cellular organism3.22e-11656
multi-tissue structure1.43e-10342
anatomical group4.99e-10625
anatomical system8.08e-10624
embryonic structure1.34e-09564
anatomical conduit2.33e-09240
germ layer5.55e-09560
germ layer / neural crest5.55e-09560
embryonic tissue5.55e-09560
presumptive structure5.55e-09560
germ layer / neural crest derived structure5.55e-09560
epiblast (generic)5.55e-09560
epithelium1.08e-08306
cell layer2.05e-08309
developing anatomical structure2.66e-07581
organ part3.28e-07218
organ3.46e-07503


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00512373949879955
E2F1#186944.907389214879320.001724022357361790.0106516310329217
EGR1#195844.988179094810140.001615011500076050.0101480167292247
MYC#460945.22228187160940.001344309395272740.00887978805470175
RAD21#5885410.35503389545638.6948481184721e-050.0012944850215896
ZBTB7A#5134147.35190930787590.000342223540015990.00346735392857295
ZNF263#1012748.221841637010680.0002187871180958320.00248991040937241



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.