Coexpression cluster:C2236: Difference between revisions
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| ||
|tfbs_overrepresentation_for_novel_motifs=0.590005,0.298605,0.581696,0.741427,0.534346,0.739643,0.821651,0.395818,0.392841,0.462021,0.706765,0.867962,0.341754,0.809319,0.532789,0.559384,1.05593,0.471262,0.356737,0.635753,0.581762,0.505745,0.731221,1.3102,0.632849,0.892087,0.316693,0.728867,0.537869,0.297585,0.682839,1.09415,0.433165,0.344471,0.49475,0.285913,0.491074,0.740899,0.463978,0.371755,0.493145,0.66492,1.63146,0.53106,1.08066,0.61613,0.822818,0.694903,0.515703,1.33034,0.90714,0.83543,0.699149,1.17354,1.33024,0.812467,0.54284,0.777235,1.46445,0.776148,1.13655,0.825354,1.0193,1.02706,0.844545,0.991076,1.42026,1.79268,1.08337,1.62905,0.650393,0.402607,0.248021,1.32819,0.336329,1.54953,0.305238,1.00941,1.08,0.62601,0.362435,1.02594,0.844168,0.399165,1.27559,0.109222,0.221873,0.291738,0.934646,1.89266,1.51507,1.24792,1.11156,1.12407,0.535192,0.456994,0.934671,1.15558,0.939507,0.272395,0.465545,1.1057,1.14983,1.05974,0.979006,0.701817,1.04326,0.805616,0.632569,0.516141,0.594299,1.14697,0.575476,0.717043,1.46636,0.489254,0.785429,0.681522,0.988625,0.444962,1.31973,0.932085,1.74599,0.856196,1.57854,1.0102,0.814847,1.11673,1.36323,0.458105,1.24863,0.68598,1.37788,0.852645,1.52813,0.774456,0.676268,0.729481,1.48509,2.34913,1.94535,1.44718,0.8167,1.15194,0.980848,0.768101,0.963351,2.1895,0.661255,0.437774,1.23342,0.175846,1.24902,0.997363,0.824835,1.65997,0.917558,0.518428,0.632914,0.600782,1.44595,1.23002,1.07918,0.604379,0.997702,0.843324,0.423521,0.820225,0.644569 | |tfbs_overrepresentation_for_novel_motifs=0.590005,0.298605,0.581696,0.741427,0.534346,0.739643,0.821651,0.395818,0.392841,0.462021,0.706765,0.867962,0.341754,0.809319,0.532789,0.559384,1.05593,0.471262,0.356737,0.635753,0.581762,0.505745,0.731221,1.3102,0.632849,0.892087,0.316693,0.728867,0.537869,0.297585,0.682839,1.09415,0.433165,0.344471,0.49475,0.285913,0.491074,0.740899,0.463978,0.371755,0.493145,0.66492,1.63146,0.53106,1.08066,0.61613,0.822818,0.694903,0.515703,1.33034,0.90714,0.83543,0.699149,1.17354,1.33024,0.812467,0.54284,0.777235,1.46445,0.776148,1.13655,0.825354,1.0193,1.02706,0.844545,0.991076,1.42026,1.79268,1.08337,1.62905,0.650393,0.402607,0.248021,1.32819,0.336329,1.54953,0.305238,1.00941,1.08,0.62601,0.362435,1.02594,0.844168,0.399165,1.27559,0.109222,0.221873,0.291738,0.934646,1.89266,1.51507,1.24792,1.11156,1.12407,0.535192,0.456994,0.934671,1.15558,0.939507,0.272395,0.465545,1.1057,1.14983,1.05974,0.979006,0.701817,1.04326,0.805616,0.632569,0.516141,0.594299,1.14697,0.575476,0.717043,1.46636,0.489254,0.785429,0.681522,0.988625,0.444962,1.31973,0.932085,1.74599,0.856196,1.57854,1.0102,0.814847,1.11673,1.36323,0.458105,1.24863,0.68598,1.37788,0.852645,1.52813,0.774456,0.676268,0.729481,1.48509,2.34913,1.94535,1.44718,0.8167,1.15194,0.980848,0.768101,0.963351,2.1895,0.661255,0.437774,1.23342,0.175846,1.24902,0.997363,0.824835,1.65997,0.917558,0.518428,0.632914,0.600782,1.44595,1.23002,1.07918,0.604379,0.997702,0.843324,0.423521,0.820225,0.644569 | ||
|tfbs_overrepresentation_jaspar=MA0003.1;0.443649,MA0004.1;0.71247,MA0006.1;0.532262,MA0007.1;0.6918,MA0009.1;1.20602,MA0014.1;0.896009,MA0017.1;0.577281,MA0019.1;2.02743,MA0024.1;1.09684,MA0025.1;1.34373,MA0027.1;2.83281,MA0028.1;0.550763,MA0029.1;1.11704,MA0030.1;1.10506,MA0031.1;1.03735,MA0038.1;0.824639,MA0040.1;1.12314,MA0041.1;0.732902,MA0042.1;0.697662,MA0043.1;1.20635,MA0046.1;1.19471,MA0048.1;0.25531,MA0050.1;0.69864,MA0051.1;0.820063,MA0052.1;1.12718,MA0055.1;0.396851,MA0056.1;0,MA0057.1;0.248209,MA0058.1;0.605914,MA0059.1;0.604454,MA0060.1;0.393285,MA0061.1;0.360128,MA0063.1;0,MA0066.1;0.825101,MA0067.1;1.53181,MA0068.1;0.313194,MA0069.1;1.19071,MA0070.1;1.17908,MA0071.1;0.782546,MA0072.1;1.1744,MA0073.1;0.599068,MA0074.1;0.819248,MA0076.1;0.623864,MA0077.1;1.16637,MA0078.1;0.926725,MA0081.1;1.4709,MA0083.1;1.21381,MA0084.1;1.72172,MA0087.1;1.17185,MA0088.1;1.02755,MA0089.1;0,MA0090.1;1.54523,MA0091.1;0.715356,MA0092.1;0.673508,MA0093.1;0.535768,MA0095.1;0,MA0098.1;0,MA0100.1;0.83965,MA0101.1;0.539569,MA0103.1;0.521546,MA0105.1;0.232357,MA0106.1;0.869173,MA0107.1;0.453492,MA0108.2;1.03412,MA0109.1;0,MA0111.1;0.655276,MA0113.1;0.886811,MA0114.1;0.447443,MA0115.1;1.45393,MA0116.1;1.15856,MA0117.1;1.24497,MA0119.1;0.586221,MA0122.1;1.27173,MA0124.1;1.41151,MA0125.1;1.32534,MA0130.1;0,MA0131.1;0.94608,MA0132.1;0,MA0133.1;0,MA0135.1;1.23748,MA0136.1;0.832277,MA0139.1;0.912459,MA0140.1;0.779643,MA0141.1;0.602484,MA0142.1;1.00381,MA0143.1;0.887001,MA0144.1;0.430413,MA0145.1;0.569905,MA0146.1;0.061409,MA0147.1;0.46175,MA0148.1;0.739888,MA0149.1;0.769072,MA0062.2;0.931615,MA0035.2;0.778873,MA0039.2;0.777367,MA0138.2;0.928035,MA0002.2;0.98779,MA0137.2;0.558189,MA0104.2;0.392359,MA0047.2;0.856092,MA0112.2;1.05083,MA0065.2;0.199162,MA0150.1;0.633493,MA0151.1;0,MA0152.1;0.78681,MA0153.1;1.30799,MA0154.1;1.88496,MA0155.1;1.02191,MA0156.1;0.560797,MA0157.1;0.97481,MA0158.1;0,MA0159.1;0.462502,MA0160.1;0.756582,MA0161.1;0,MA0162.1;0.309472,MA0163.1;0.539587,MA0164.1;0.90014,MA0080.2;0.535868,MA0018.2;0.870662,MA0099.2;0.7872,MA0079.2;0.327251,MA0102.2;1.75932,MA0258.1;1.88931,MA0259.1;0.471671,MA0442.1;0 | |||
}} | }} |
Revision as of 20:30, 22 January 2013
Full id: C2236_Eosinophils_Neutrophils_CD14CD16_CD14_Mast_Whole_CD19
Phase1 CAGE Peaks
Hg19::chr12:7060508..7060609,+ | p1@PTPN6 |
Hg19::chr12:7060615..7060624,+ | p8@PTPN6 |
Hg19::chr19:41848208..41848225,- | p18@TGFB1 |
Hg19::chr5:55711409..55711446,+ | p@chr5:55711409..55711446 + |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
6.45030198789693e-06 | 0.00408304115833875 | 2 | 73 | Leishmaniasis (KEGG):05140 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006470 | protein amino acid dephosphorylation | 0.00206049010094955 |
GO:0045066 | regulatory T cell differentiation | 0.00206049010094955 |
GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 0.00206049010094955 |
GO:0009814 | defense response, incompatible interaction | 0.00206049010094955 |
GO:0009817 | defense response to fungus, incompatible interaction | 0.00206049010094955 |
GO:0050765 | negative regulation of phagocytosis | 0.00206049010094955 |
GO:0016311 | dephosphorylation | 0.00206049010094955 |
GO:0019049 | evasion of host defenses by virus | 0.00206049010094955 |
GO:0044415 | evasion or tolerance of host defenses | 0.00206049010094955 |
GO:0052173 | response to defenses of other organism during symbiotic interaction | 0.00206049010094955 |
GO:0048290 | isotype switching to IgA isotypes | 0.00206049010094955 |
GO:0035306 | positive regulation of dephosphorylation | 0.00206049010094955 |
GO:0044413 | avoidance of host defenses | 0.00206049010094955 |
GO:0051834 | evasion or tolerance of defenses of other organism during symbiotic interaction | 0.00206049010094955 |
GO:0048298 | positive regulation of isotype switching to IgA isotypes | 0.00206049010094955 |
GO:0051832 | avoidance of defenses of other organism during symbiotic interaction | 0.00206049010094955 |
GO:0035304 | regulation of protein amino acid dephosphorylation | 0.00206049010094955 |
GO:0052200 | response to host defenses | 0.00206049010094955 |
GO:0048296 | regulation of isotype switching to IgA isotypes | 0.00206049010094955 |
GO:0035307 | positive regulation of protein amino acid dephosphorylation | 0.00206049010094955 |
GO:0009611 | response to wounding | 0.00257793593993739 |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 0.00268755622605763 |
GO:0007406 | negative regulation of neuroblast proliferation | 0.00268755622605763 |
GO:0007184 | SMAD protein nuclear translocation | 0.00316989145488023 |
GO:0045806 | negative regulation of endocytosis | 0.00316989145488023 |
GO:0031536 | positive regulation of exit from mitosis | 0.00316989145488023 |
GO:0035303 | regulation of dephosphorylation | 0.00355241227247147 |
GO:0001784 | phosphotyrosine binding | 0.00355241227247147 |
GO:0048535 | lymph node development | 0.00355241227247147 |
GO:0009605 | response to external stimulus | 0.00374612507344501 |
GO:0045830 | positive regulation of isotype switching | 0.00374612507344501 |
GO:0008354 | germ cell migration | 0.00374612507344501 |
GO:0045309 | protein phosphorylated amino acid binding | 0.00374612507344501 |
GO:0051283 | negative regulation of sequestering of calcium ion | 0.00405788400909243 |
GO:0051282 | regulation of sequestering of calcium ion | 0.00405788400909243 |
GO:0051209 | release of sequestered calcium ion into cytosol | 0.00405788400909243 |
GO:0030279 | negative regulation of ossification | 0.00405788400909243 |
GO:0050777 | negative regulation of immune response | 0.00405788400909243 |
GO:0045191 | regulation of isotype switching | 0.00405788400909243 |
GO:0002683 | negative regulation of immune system process | 0.00405788400909243 |
GO:0031575 | G1/S transition checkpoint | 0.00405788400909243 |
GO:0051208 | sequestering of calcium ion | 0.00405788400909243 |
GO:0051219 | phosphoprotein binding | 0.00405788400909243 |
GO:0050764 | regulation of phagocytosis | 0.00405788400909243 |
GO:0006915 | apoptosis | 0.00405788400909243 |
GO:0012501 | programmed cell death | 0.00405788400909243 |
GO:0002208 | somatic diversification of immunoglobulins during immune response | 0.00405788400909243 |
GO:0002381 | immunoglobulin production during immune response | 0.00405788400909243 |
GO:0051101 | regulation of DNA binding | 0.00405788400909243 |
GO:0002204 | somatic recombination of immunoglobulin genes during immune response | 0.00405788400909243 |
GO:0005160 | transforming growth factor beta receptor binding | 0.00405788400909243 |
GO:0001837 | epithelial to mesenchymal transition | 0.00405788400909243 |
GO:0019048 | virus-host interaction | 0.00405788400909243 |
GO:0045190 | isotype switching | 0.00405788400909243 |
GO:0046851 | negative regulation of bone remodeling | 0.00405788400909243 |
GO:0050768 | negative regulation of neurogenesis | 0.00405788400909243 |
GO:0050680 | negative regulation of epithelial cell proliferation | 0.00405788400909243 |
GO:0050832 | defense response to fungus | 0.00405788400909243 |
GO:0016265 | death | 0.00405788400909243 |
GO:0008219 | cell death | 0.00405788400909243 |
GO:0016447 | somatic recombination of immunoglobulin gene segments | 0.00405788400909243 |
GO:0045930 | negative regulation of progression through mitotic cell cycle | 0.00405788400909243 |
GO:0016202 | regulation of striated muscle development | 0.00405788400909243 |
GO:0010458 | exit from mitosis | 0.00405788400909243 |
GO:0007096 | regulation of exit from mitosis | 0.00405788400909243 |
GO:0051238 | sequestering of metal ion | 0.00405788400909243 |
GO:0016444 | somatic cell DNA recombination | 0.00447846922097053 |
GO:0016445 | somatic diversification of immunoglobulins | 0.00447846922097053 |
GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | 0.00447846922097053 |
GO:0002200 | somatic diversification of immune receptors | 0.00470872117487484 |
GO:0007405 | neuroblast proliferation | 0.00493247861524983 |
GO:0050679 | positive regulation of epithelial cell proliferation | 0.00501082262934408 |
GO:0002377 | immunoglobulin production | 0.00501082262934408 |
GO:0050871 | positive regulation of B cell activation | 0.00501082262934408 |
GO:0009620 | response to fungus | 0.00508305403775861 |
GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 0.00508305403775861 |
GO:0030278 | regulation of ossification | 0.00508305403775861 |
GO:0006950 | response to stress | 0.00552651683656853 |
GO:0042306 | regulation of protein import into nucleus | 0.00552651683656853 |
GO:0051701 | interaction with host | 0.00552651683656853 |
GO:0000060 | protein import into nucleus, translocation | 0.00552651683656853 |
GO:0033157 | regulation of intracellular protein transport | 0.00552651683656853 |
GO:0048468 | cell development | 0.00563188635386827 |
GO:0051092 | activation of NF-kappaB transcription factor | 0.00564007429432708 |
GO:0046850 | regulation of bone remodeling | 0.00565877078367979 |
GO:0014031 | mesenchymal cell development | 0.00565877078367979 |
GO:0048762 | mesenchymal cell differentiation | 0.00565877078367979 |
GO:0051241 | negative regulation of multicellular organismal process | 0.00565877078367979 |
GO:0045937 | positive regulation of phosphate metabolic process | 0.00565877078367979 |
GO:0050864 | regulation of B cell activation | 0.00565877078367979 |
GO:0032386 | regulation of intracellular transport | 0.00565877078367979 |
GO:0042552 | myelination | 0.005821067193276 |
GO:0007093 | mitotic cell cycle checkpoint | 0.00591625123079949 |
GO:0002440 | production of molecular mediator of immune response | 0.00591625123079949 |
GO:0051223 | regulation of protein transport | 0.00600746294850141 |
GO:0051098 | regulation of binding | 0.00600746294850141 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0061577800398386 |
GO:0051091 | positive regulation of transcription factor activity | 0.00621760082049371 |
GO:0050678 | regulation of epithelial cell proliferation | 0.00621760082049371 |
GO:0051051 | negative regulation of transport | 0.00621760082049371 |
GO:0001763 | morphogenesis of a branching structure | 0.00621760082049371 |
GO:0044403 | symbiosis, encompassing mutualism through parasitism | 0.00621760082049371 |
GO:0007272 | ensheathment of neurons | 0.00621760082049371 |
GO:0008366 | axon ensheathment | 0.00621760082049371 |
GO:0044419 | interspecies interaction between organisms | 0.00621760082049371 |
GO:0007346 | regulation of progression through mitotic cell cycle | 0.00621760082049371 |
GO:0050673 | epithelial cell proliferation | 0.00635188300532194 |
GO:0030100 | regulation of endocytosis | 0.00642418962948427 |
GO:0030424 | axon | 0.00642418962948427 |
GO:0030141 | secretory granule | 0.00692716904027421 |
GO:0050767 | regulation of neurogenesis | 0.00705019239876943 |
GO:0047485 | protein N-terminus binding | 0.00717101349592748 |
GO:0001508 | regulation of action potential | 0.00727858622798703 |
GO:0051235 | maintenance of localization | 0.00727858622798703 |
GO:0006909 | phagocytosis | 0.00727858622798703 |
GO:0030217 | T cell differentiation | 0.00727858622798703 |
GO:0006793 | phosphorus metabolic process | 0.00739714753182425 |
GO:0006796 | phosphate metabolic process | 0.00739714753182425 |
GO:0001666 | response to hypoxia | 0.00820673422484349 |
GO:0048869 | cellular developmental process | 0.00820673422484349 |
GO:0030154 | cell differentiation | 0.00820673422484349 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 0.00843866546840953 |
GO:0016064 | immunoglobulin mediated immune response | 0.0084684843854286 |
GO:0051251 | positive regulation of lymphocyte activation | 0.0084684843854286 |
GO:0051090 | regulation of transcription factor activity | 0.00849735185625042 |
GO:0019724 | B cell mediated immunity | 0.00849735185625042 |
GO:0030308 | negative regulation of cell growth | 0.00859244092463929 |
GO:0045792 | negative regulation of cell size | 0.008686039487641 |
GO:0000075 | cell cycle checkpoint | 0.00893765386618177 |
GO:0022415 | viral reproductive process | 0.00902714296975374 |
GO:0042113 | B cell activation | 0.00951369295350302 |
GO:0045926 | negative regulation of growth | 0.00951369295350302 |
GO:0010033 | response to organic substance | 0.00959680958217342 |
GO:0042493 | response to drug | 0.009678681137634 |
GO:0030098 | lymphocyte differentiation | 0.00975933528817835 |
GO:0007088 | regulation of mitosis | 0.0101412323453735 |
GO:0051174 | regulation of phosphorus metabolic process | 0.0102921391075896 |
GO:0019220 | regulation of phosphate metabolic process | 0.0102921391075896 |
GO:0007204 | elevation of cytosolic calcium ion concentration | 0.0102921391075896 |
GO:0051480 | cytosolic calcium ion homeostasis | 0.0102921391075896 |
GO:0002449 | lymphocyte mediated immunity | 0.0105108110616537 |
GO:0043687 | post-translational protein modification | 0.0106637744193752 |
GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 0.0107141565090489 |
GO:0002250 | adaptive immune response | 0.0107141565090489 |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0107141565090489 |
GO:0051249 | regulation of lymphocyte activation | 0.0107141565090489 |
GO:0051093 | negative regulation of developmental process | 0.0107811289564368 |
GO:0002443 | leukocyte mediated immunity | 0.0108471922724222 |
GO:0050865 | regulation of cell activation | 0.0110503331282197 |
GO:0043005 | neuron projection | 0.011113708774458 |
GO:0051247 | positive regulation of protein metabolic process | 0.0115846157013033 |
GO:0007166 | cell surface receptor linked signal transduction | 0.0116834586654113 |
GO:0014706 | striated muscle development | 0.0116834586654113 |
GO:0001503 | ossification | 0.0116834586654113 |
GO:0031214 | biomineral formation | 0.0116834586654113 |
GO:0002521 | leukocyte differentiation | 0.0118720457812149 |
GO:0046849 | bone remodeling | 0.012502112220223 |
GO:0006606 | protein import into nucleus | 0.012502112220223 |
GO:0051170 | nuclear import | 0.0125243917682088 |
GO:0042110 | T cell activation | 0.0125243917682088 |
GO:0050776 | regulation of immune response | 0.0125243917682088 |
GO:0002682 | regulation of immune system process | 0.0127007283478821 |
GO:0007050 | cell cycle arrest | 0.0127488499470269 |
GO:0048771 | tissue remodeling | 0.0131721626333633 |
GO:0006464 | protein modification process | 0.0134340631775533 |
GO:0002252 | immune effector process | 0.0135505160932149 |
GO:0051049 | regulation of transport | 0.0135505160932149 |
GO:0045087 | innate immune response | 0.0139588481081739 |
GO:0055074 | calcium ion homeostasis | 0.0140362234715278 |
GO:0006874 | cellular calcium ion homeostasis | 0.0140362234715278 |
GO:0043412 | biopolymer modification | 0.0140489859928888 |
GO:0017038 | protein import | 0.0145395928833342 |
GO:0006875 | cellular metal ion homeostasis | 0.0145395928833342 |
GO:0055065 | metal ion homeostasis | 0.0145395928833342 |
GO:0042060 | wound healing | 0.0153949540833138 |
GO:0006913 | nucleocytoplasmic transport | 0.017988952623837 |
GO:0046649 | lymphocyte activation | 0.0180032059714914 |
GO:0051169 | nuclear transport | 0.0180172957615725 |
GO:0030097 | hemopoiesis | 0.0184895278787589 |
GO:0001558 | regulation of cell growth | 0.0185007391088173 |
GO:0032502 | developmental process | 0.0187647019955975 |
GO:0007517 | muscle development | 0.0194240394070176 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.0194299237665899 |
GO:0045321 | leukocyte activation | 0.0199954876014571 |
GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.0199954876014571 |
GO:0002520 | immune system development | 0.0201083690822038 |
GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0201104356201654 |
GO:0006310 | DNA recombination | 0.0213027112445465 |
GO:0010324 | membrane invagination | 0.0213027112445465 |
GO:0006897 | endocytosis | 0.0213027112445465 |
GO:0030003 | cellular cation homeostasis | 0.0213961365321492 |
GO:0016049 | cell growth | 0.0213961365321492 |
GO:0040008 | regulation of growth | 0.0213961365321492 |
GO:0055080 | cation homeostasis | 0.0214970119510755 |
GO:0008361 | regulation of cell size | 0.0215911465360642 |
GO:0051707 | response to other organism | 0.0215911465360642 |
GO:0001775 | cell activation | 0.0216833518416847 |
GO:0001501 | skeletal development | 0.0216833518416847 |
GO:0006917 | induction of apoptosis | 0.021876068821807 |
GO:0012502 | induction of programmed cell death | 0.021876068821807 |
GO:0004725 | protein tyrosine phosphatase activity | 0.0221662759483106 |
GO:0006605 | protein targeting | 0.0221662759483106 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0225409065093586 |
GO:0008285 | negative regulation of cell proliferation | 0.0225409065093586 |
GO:0045786 | negative regulation of progression through cell cycle | 0.0225409065093586 |
GO:0008284 | positive regulation of cell proliferation | 0.0231140999528246 |
GO:0016477 | cell migration | 0.0231140999528246 |
GO:0050793 | regulation of developmental process | 0.0231736693375057 |
GO:0006873 | cellular ion homeostasis | 0.0231736693375057 |
GO:0055082 | cellular chemical homeostasis | 0.0231736693375057 |
GO:0007067 | mitosis | 0.0232577860515655 |
GO:0048699 | generation of neurons | 0.0234376026025504 |
GO:0000087 | M phase of mitotic cell cycle | 0.0236157051062257 |
GO:0008083 | growth factor activity | 0.0242700046495253 |
GO:0043065 | positive regulation of apoptosis | 0.0244424856494988 |
GO:0043068 | positive regulation of programmed cell death | 0.0245186743594489 |
GO:0022008 | neurogenesis | 0.024782603119839 |
GO:0007276 | gamete generation | 0.0248564992906902 |
GO:0050801 | ion homeostasis | 0.0250230604966794 |
GO:0051239 | regulation of multicellular organismal process | 0.0258384340947735 |
GO:0045941 | positive regulation of transcription | 0.025906467296979 |
GO:0016044 | membrane organization and biogenesis | 0.0262500139072716 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0264182343048339 |
GO:0009607 | response to biotic stimulus | 0.0264182343048339 |
GO:0006954 | inflammatory response | 0.0264182343048339 |
GO:0016481 | negative regulation of transcription | 0.0264182343048339 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0271117065808389 |
GO:0048878 | chemical homeostasis | 0.0271719441412501 |
GO:0009888 | tissue development | 0.0271726741397441 |
GO:0022414 | reproductive process | 0.0271726741397441 |
GO:0000279 | M phase | 0.0271726741397441 |
GO:0016563 | transcription activator activity | 0.0273195892415244 |
GO:0042995 | cell projection | 0.0274350947975721 |
GO:0004721 | phosphoprotein phosphatase activity | 0.0274350947975721 |
GO:0019953 | sexual reproduction | 0.0274920948196355 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0277215898472288 |
GO:0000278 | mitotic cell cycle | 0.0282074449957576 |
GO:0019226 | transmission of nerve impulse | 0.0284318936848912 |
GO:0051704 | multi-organism process | 0.0285690544056786 |
GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0296399746567695 |
GO:0031988 | membrane-bound vesicle | 0.02990063306683 |
GO:0000074 | regulation of progression through cell cycle | 0.02990063306683 |
GO:0051726 | regulation of cell cycle | 0.0302810314848609 |
GO:0009887 | organ morphogenesis | 0.0304075868306677 |
GO:0031325 | positive regulation of cellular metabolic process | 0.0305330867900803 |
GO:0022403 | cell cycle phase | 0.0307403978631971 |
GO:0019725 | cellular homeostasis | 0.0311110003802775 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0313896883456635 |
GO:0006928 | cell motility | 0.0313896883456635 |
GO:0051674 | localization of cell | 0.0313896883456635 |
GO:0009893 | positive regulation of metabolic process | 0.0318139601688625 |
GO:0007165 | signal transduction | 0.0318139601688625 |
GO:0005578 | proteinaceous extracellular matrix | 0.0340217146424188 |
GO:0051246 | regulation of protein metabolic process | 0.0340217146424188 |
GO:0031410 | cytoplasmic vesicle | 0.0341276918296541 |
GO:0031982 | vesicle | 0.0345507055252033 |
GO:0009892 | negative regulation of metabolic process | 0.0347328780898267 |
GO:0016791 | phosphoric monoester hydrolase activity | 0.0347559323918043 |
GO:0007154 | cell communication | 0.0361918096548299 |
GO:0044267 | cellular protein metabolic process | 0.0363645558128093 |
GO:0042127 | regulation of cell proliferation | 0.0367711650166377 |
GO:0044260 | cellular macromolecule metabolic process | 0.037023657213381 |
GO:0032989 | cellular structure morphogenesis | 0.0370459803513501 |
GO:0000902 | cell morphogenesis | 0.0370459803513501 |
GO:0042592 | homeostatic process | 0.0370595047182018 |
GO:0019538 | protein metabolic process | 0.0391184422583096 |
GO:0005615 | extracellular space | 0.0403561355709879 |
GO:0006886 | intracellular protein transport | 0.0403561355709879 |
GO:0042981 | regulation of apoptosis | 0.0432959286704676 |
GO:0042578 | phosphoric ester hydrolase activity | 0.0434249170822596 |
GO:0043067 | regulation of programmed cell death | 0.0434249170822596 |
GO:0006952 | defense response | 0.0438609639151437 |
GO:0042221 | response to chemical stimulus | 0.0440711758487935 |
GO:0016192 | vesicle-mediated transport | 0.0451662904214498 |
GO:0022402 | cell cycle process | 0.046399908682708 |
GO:0007267 | cell-cell signaling | 0.0473308073613599 |
GO:0065009 | regulation of a molecular function | 0.049421473323182 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 1.95e-59 | 98 |
blood island | 1.95e-59 | 98 |
hemolymphoid system | 4.98e-54 | 108 |
bone marrow | 1.04e-45 | 76 |
immune system | 5.18e-45 | 93 |
bone element | 1.71e-40 | 82 |
skeletal element | 1.16e-34 | 90 |
skeletal system | 9.44e-29 | 100 |
connective tissue | 5.96e-18 | 371 |
lateral plate mesoderm | 1.15e-16 | 203 |
musculoskeletal system | 1.30e-09 | 167 |
blood | 3.24e-09 | 15 |
haemolymphatic fluid | 3.24e-09 | 15 |
organism substance | 3.24e-09 | 15 |
Ontology term | p-value | n |
---|---|---|
hematologic cancer | 5.26e-07 | 51 |
immune system cancer | 5.26e-07 | 51 |
leukemia | 8.36e-07 | 39 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.443649 |
MA0004.1 | 0.71247 |
MA0006.1 | 0.532262 |
MA0007.1 | 0.6918 |
MA0009.1 | 1.20602 |
MA0014.1 | 0.896009 |
MA0017.1 | 0.577281 |
MA0019.1 | 2.02743 |
MA0024.1 | 1.09684 |
MA0025.1 | 1.34373 |
MA0027.1 | 2.83281 |
MA0028.1 | 0.550763 |
MA0029.1 | 1.11704 |
MA0030.1 | 1.10506 |
MA0031.1 | 1.03735 |
MA0038.1 | 0.824639 |
MA0040.1 | 1.12314 |
MA0041.1 | 0.732902 |
MA0042.1 | 0.697662 |
MA0043.1 | 1.20635 |
MA0046.1 | 1.19471 |
MA0048.1 | 0.25531 |
MA0050.1 | 0.69864 |
MA0051.1 | 0.820063 |
MA0052.1 | 1.12718 |
MA0055.1 | 0.396851 |
MA0056.1 | 0 |
MA0057.1 | 0.248209 |
MA0058.1 | 0.605914 |
MA0059.1 | 0.604454 |
MA0060.1 | 0.393285 |
MA0061.1 | 0.360128 |
MA0063.1 | 0 |
MA0066.1 | 0.825101 |
MA0067.1 | 1.53181 |
MA0068.1 | 0.313194 |
MA0069.1 | 1.19071 |
MA0070.1 | 1.17908 |
MA0071.1 | 0.782546 |
MA0072.1 | 1.1744 |
MA0073.1 | 0.599068 |
MA0074.1 | 0.819248 |
MA0076.1 | 0.623864 |
MA0077.1 | 1.16637 |
MA0078.1 | 0.926725 |
MA0081.1 | 1.4709 |
MA0083.1 | 1.21381 |
MA0084.1 | 1.72172 |
MA0087.1 | 1.17185 |
MA0088.1 | 1.02755 |
MA0089.1 | 0 |
MA0090.1 | 1.54523 |
MA0091.1 | 0.715356 |
MA0092.1 | 0.673508 |
MA0093.1 | 0.535768 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.83965 |
MA0101.1 | 0.539569 |
MA0103.1 | 0.521546 |
MA0105.1 | 0.232357 |
MA0106.1 | 0.869173 |
MA0107.1 | 0.453492 |
MA0108.2 | 1.03412 |
MA0109.1 | 0 |
MA0111.1 | 0.655276 |
MA0113.1 | 0.886811 |
MA0114.1 | 0.447443 |
MA0115.1 | 1.45393 |
MA0116.1 | 1.15856 |
MA0117.1 | 1.24497 |
MA0119.1 | 0.586221 |
MA0122.1 | 1.27173 |
MA0124.1 | 1.41151 |
MA0125.1 | 1.32534 |
MA0130.1 | 0 |
MA0131.1 | 0.94608 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.23748 |
MA0136.1 | 0.832277 |
MA0139.1 | 0.912459 |
MA0140.1 | 0.779643 |
MA0141.1 | 0.602484 |
MA0142.1 | 1.00381 |
MA0143.1 | 0.887001 |
MA0144.1 | 0.430413 |
MA0145.1 | 0.569905 |
MA0146.1 | 0.061409 |
MA0147.1 | 0.46175 |
MA0148.1 | 0.739888 |
MA0149.1 | 0.769072 |
MA0062.2 | 0.931615 |
MA0035.2 | 0.778873 |
MA0039.2 | 0.777367 |
MA0138.2 | 0.928035 |
MA0002.2 | 0.98779 |
MA0137.2 | 0.558189 |
MA0104.2 | 0.392359 |
MA0047.2 | 0.856092 |
MA0112.2 | 1.05083 |
MA0065.2 | 0.199162 |
MA0150.1 | 0.633493 |
MA0151.1 | 0 |
MA0152.1 | 0.78681 |
MA0153.1 | 1.30799 |
MA0154.1 | 1.88496 |
MA0155.1 | 1.02191 |
MA0156.1 | 0.560797 |
MA0157.1 | 0.97481 |
MA0158.1 | 0 |
MA0159.1 | 0.462502 |
MA0160.1 | 0.756582 |
MA0161.1 | 0 |
MA0162.1 | 0.309472 |
MA0163.1 | 0.539587 |
MA0164.1 | 0.90014 |
MA0080.2 | 0.535868 |
MA0018.2 | 0.870662 |
MA0099.2 | 0.7872 |
MA0079.2 | 0.327251 |
MA0102.2 | 1.75932 |
MA0258.1 | 1.88931 |
MA0259.1 | 0.471671 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
EBF1#1879 | 3 | 6.67985013492675 | 0.00518429411827891 | 0.0240395370696147 |
PBX3#5090 | 2 | 10.9572563433721 | 0.0117453018068803 | 0.0428245906789825 |
SPI1#6688 | 3 | 6.15324263139204 | 0.00658038711305903 | 0.0280922600433605 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.