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Coexpression cluster:C421

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Full id: C421_Smooth_Fibroblast_epithelioid_hepatic_Sertoli_Ewing_tenocyte



Phase1 CAGE Peaks

Hg19::chr10:74856613..74856631,-p1@P4HA1
Hg19::chr5:121399703..121399718,-p@chr5:121399703..121399718
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Hg19::chr5:121400446..121400468,-p@chr5:121400446..121400468
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Hg19::chr5:121400825..121400873,-p@chr5:121400825..121400873
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Hg19::chr5:121400881..121400901,-p@chr5:121400881..121400901
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Hg19::chr5:121401627..121401642,-p@chr5:121401627..121401642
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Hg19::chr5:121401645..121401695,-p@chr5:121401645..121401695
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Hg19::chr5:121401698..121401726,-p@chr5:121401698..121401726
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Hg19::chr5:121401731..121401748,-p@chr5:121401731..121401748
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Hg19::chr5:121401877..121401903,-p@chr5:121401877..121401903
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Hg19::chr5:121402009..121402030,-p@chr5:121402009..121402030
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Hg19::chr5:121402258..121402287,-p@chr5:121402258..121402287
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Hg19::chr5:121406259..121406287,-p@chr5:121406259..121406287
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Hg19::chr5:121409731..121409737,-p@chr5:121409731..121409737
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Hg19::chr5:121409743..121409755,-p@chr5:121409743..121409755
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Hg19::chr5:121411148..121411162,-p@chr5:121411148..121411162
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Hg19::chr5:121411232..121411247,-p@chr5:121411232..121411247
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Hg19::chr5:121412666..121412683,-p9@LOX
Hg19::chr5:121413171..121413182,-p5@LOX
Hg19::chr5:121413944..121413965,-p1@LOX
Hg19::chr5:121413974..121413986,-p4@LOX
Hg19::chr5:121414004..121414025,-p3@LOX
Hg19::chr5:121414045..121414063,-p2@LOX
Hg19::chr5:121414152..121414179,-p10@LOX


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0031545peptidyl-proline 4-dioxygenase activity0.00429753038433406
GO:0048251elastic fiber assembly0.00429753038433406
GO:0004656procollagen-proline 4-dioxygenase activity0.00429753038433406
GO:0019798procollagen-proline dioxygenase activity0.00572961881385015
GO:0031543peptidyl-proline dioxygenase activity0.00572961881385015
GO:0004720protein-lysine 6-oxidase activity0.00572961881385015
GO:0030199collagen fibril organization0.00613869657258434
GO:0031418L-ascorbic acid binding0.01097934462629
GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor0.01097934462629
GO:0016638oxidoreductase activity, acting on the CH-NH2 group of donors0.0120286572408851
GO:0016491oxidoreductase activity0.0131707519804101
GO:0030324lung development0.0131707519804101
GO:0030323respiratory tube development0.0131707519804101
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.0131707519804101
GO:0030198extracellular matrix organization and biogenesis0.0131707519804101
GO:0005581collagen0.014493277316521
GO:0005788endoplasmic reticulum lumen0.0161644116411761
GO:0051213dioxygenase activity0.0171696269856064
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen0.0171696269856064
GO:0016701oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.0171696269856064
GO:0043062extracellular structure organization and biogenesis0.0171696269856064
GO:0035295tube development0.0218246679385887
GO:0005507copper ion binding0.0218246679385887
GO:0044420extracellular matrix part0.0234131593350398
GO:0001568blood vessel development0.027372249835033
GO:0001944vasculature development0.027372249835033
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0281005465565403
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0321332748221334
GO:0019842vitamin binding0.0361773988863747
GO:0007167enzyme linked receptor protein signaling pathway0.0427874371191506
GO:0046914transition metal ion binding0.0490018528809785



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
somite4.18e-2083
paraxial mesoderm4.18e-2083
presomitic mesoderm4.18e-2083
presumptive segmental plate4.18e-2083
trunk paraxial mesoderm4.18e-2083
presumptive paraxial mesoderm4.18e-2083
dermomyotome4.50e-1970
vasculature1.28e-1779
vascular system1.28e-1779
splanchnic layer of lateral plate mesoderm1.55e-1784
trunk mesenchyme2.03e-17143
skeletal muscle tissue3.48e-1761
striated muscle tissue3.48e-1761
myotome3.48e-1761
muscle tissue1.04e-1663
musculature1.04e-1663
musculature of body1.04e-1663
multilaminar epithelium1.14e-1682
vessel7.26e-1569
blood vessel6.56e-1460
epithelial tube open at both ends6.56e-1460
blood vasculature6.56e-1460
vascular cord6.56e-1460
epithelial tube7.66e-14118
unilaminar epithelium1.03e-13138
trunk6.85e-13216
artery7.13e-1342
arterial blood vessel7.13e-1342
arterial system7.13e-1342
cardiovascular system1.04e-12110
circulatory system1.72e-12113
multi-cellular organism2.28e-12659
systemic artery5.81e-1133
systemic arterial system5.81e-1133
organism subdivision8.83e-11365
mesenchyme2.47e-09238
entire embryonic mesenchyme2.47e-09238
anatomical system2.89e-09625
anatomical group3.43e-09626
multi-tissue structure9.93e-09347
cell layer1.14e-08312
epithelium3.14e-08309
surface structure8.37e-0895
anatomical cluster1.04e-07286
mesoderm2.22e-07448
mesoderm-derived structure2.22e-07448
presumptive mesoderm2.22e-07448
integument4.26e-0745
integumental system4.26e-0745
aorta5.25e-0721
aortic system5.25e-0721
Disease
Ontology termp-valuen
ovarian cancer2.47e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.