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Coexpression cluster:C1286

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Full id: C1286_myelodysplastic_acute_leukemia_biphenotypic_CD14CD16_splenic_Dendritic



Phase1 CAGE Peaks

Hg19::chr8:130560794..130560810,-p@chr8:130560794..130560810
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Hg19::chr8:130560812..130560823,-p@chr8:130560812..130560823
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Hg19::chr8:130560843..130560854,-p@chr8:130560843..130560854
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Hg19::chr8:130560902..130560915,-p@chr8:130560902..130560915
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Hg19::chr8:130560925..130560948,-p@chr8:130560925..130560948
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Hg19::chr8:130560949..130560959,-p@chr8:130560949..130560959
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Hg19::chr8:27184282..27184305,+p6@PTK2B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
myeloid cell7.90e-33108
common myeloid progenitor7.90e-33108
hematopoietic oligopotent progenitor cell4.30e-28161
hematopoietic multipotent progenitor cell4.30e-28161
hematopoietic stem cell2.03e-26168
angioblastic mesenchymal cell2.03e-26168
macrophage dendritic cell progenitor1.77e-2461
hematopoietic cell1.83e-24177
monopoietic cell1.99e-2359
monocyte1.99e-2359
monoblast1.99e-2359
promonocyte1.99e-2359
granulocyte monocyte progenitor cell1.10e-2167
myeloid lineage restricted progenitor cell2.92e-2066
myeloid leukocyte1.10e-1972
classical monocyte1.78e-1942
CD14-positive, CD16-negative classical monocyte1.78e-1942
hematopoietic lineage restricted progenitor cell5.16e-17120
nongranular leukocyte8.18e-17115
defensive cell2.05e-1648
phagocyte2.05e-1648
intermediate monocyte2.76e-159
CD14-positive, CD16-positive monocyte2.76e-159
leukocyte4.11e-15136
non-classical monocyte7.33e-103
CD14-low, CD16-positive monocyte7.33e-103
immature conventional dendritic cell6.37e-085
common dendritic progenitor6.37e-085
stuff accumulating cell5.48e-0787
Uber Anatomy
Ontology termp-valuen
immune system4.46e-2193
hematopoietic system1.37e-1998
blood island1.37e-1998
bone marrow2.54e-1876
hemolymphoid system4.94e-17108
bone element1.71e-1682
skeletal element1.93e-1490
skeletal system2.41e-12100
hemopoietic organ4.60e-107
immune organ4.60e-107
spleen2.54e-093
gastrointestinal system mesentery2.54e-093
stomach region2.54e-093
mesentery2.54e-093
gastrointestinal system serosa2.54e-093
mesentery of stomach2.54e-093
gut mesentery2.54e-093
dorsal mesentery2.54e-093
dorsal mesogastrium2.54e-093
peritoneal cavity2.54e-093
spleen primordium2.54e-093
neural tube9.33e-0856
neural rod9.33e-0856
future spinal cord9.33e-0856
neural keel9.33e-0856
regional part of nervous system3.41e-0753
regional part of brain3.41e-0753
brainstem6.49e-076
basal ganglion6.63e-079
nuclear complex of neuraxis6.63e-079
aggregate regional part of brain6.63e-079
collection of basal ganglia6.63e-079
cerebral subcortex6.63e-079
neural nucleus6.91e-079
nucleus of brain6.91e-079
Disease
Ontology termp-valuen
myeloid leukemia8.41e-2231
leukemia3.40e-2139
hematologic cancer5.73e-1951
immune system cancer5.73e-1951


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538620.87811582197453.22775058778003e-082.17345611629374e-06
BCL11A#53335624.31667580309181.29931738009616e-089.61043965013196e-07
EBF1#187978.9064668465692.2473547136215e-071.19324595290247e-05
IRF4#3662412.52257867813950.0001356731131035550.00177719356069513
MEF2A#4205410.71041766265370.0002487360970091120.00268309742155904
NFKB1#479075.488063424193846.66568321176054e-060.000195002041723546
PAX5#507965.716770455295286.92762487228137e-050.00109956567482704
POU2F2#545267.805249192350731.11144903558223e-050.000284715785693336
RXRA#625638.603407345342830.003716461561497260.0187409361702097
SRF#6722611.82615279614389.50741412579311e-074.0677788770328e-05
USF1#739165.452713666178259.13505145927422e-050.00133173595666547
USF2#7392611.13616918720251.35815928956223e-065.33853210547948e-05
YY1#752864.209574928446160.000411683378865750.0039233324578301



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.