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Coexpression cluster:C2761

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Full id: C2761_Wilms_duodenum_amygdala_cerebellum_hippocampus_neuroblastoma_temporal



Phase1 CAGE Peaks

  Short description
Hg19::chr3:96532496..96532521,+ p@chr3:96532496..96532521
+
Hg19::chr3:96533374..96533391,+ p4@EPHA6
Hg19::chr3:96533397..96533411,+ p2@EPHA6
Hg19::chr3:96533413..96533443,+ p1@EPHA6


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube1.19e-4656
neural rod1.19e-4656
future spinal cord1.19e-4656
neural keel1.19e-4656
adult organism2.20e-44114
regional part of nervous system2.24e-4353
regional part of brain2.24e-4353
nervous system2.61e-4289
central nervous system1.29e-4181
brain3.77e-3768
future brain3.77e-3768
cerebral hemisphere1.65e-3632
telencephalon3.59e-3634
brain grey matter4.65e-3634
gray matter4.65e-3634
regional part of forebrain4.23e-3541
forebrain4.23e-3541
anterior neural tube4.23e-3541
future forebrain4.23e-3541
regional part of telencephalon1.07e-3332
neural plate2.52e-3282
presumptive neural plate2.52e-3282
neurectoderm2.02e-3186
regional part of cerebral cortex3.61e-3122
neocortex4.15e-2820
organ system subdivision6.33e-28223
cerebral cortex1.25e-2625
pallium1.25e-2625
pre-chordal neural plate3.16e-2561
ecto-epithelium1.36e-24104
ectoderm-derived structure2.74e-21171
ectoderm2.74e-21171
presumptive ectoderm2.74e-21171
structure with developmental contribution from neural crest1.74e-20132
anatomical cluster4.70e-16373
posterior neural tube2.33e-1215
chordal neural plate2.33e-1215
basal ganglion1.71e-119
nuclear complex of neuraxis1.71e-119
aggregate regional part of brain1.71e-119
collection of basal ganglia1.71e-119
cerebral subcortex1.71e-119
tube8.14e-11192
neural nucleus8.90e-119
nucleus of brain8.90e-119
multi-tissue structure1.59e-10342
gyrus5.14e-106
organ part8.14e-10218
anatomical conduit1.14e-09240
segmental subdivision of hindbrain2.39e-0912
hindbrain2.39e-0912
presumptive hindbrain2.39e-0912
limbic system3.31e-095
temporal lobe8.09e-096
brainstem1.01e-086
occipital lobe1.07e-085
telencephalic nucleus1.72e-087
segmental subdivision of nervous system1.86e-0813
parietal lobe3.16e-085
embryo3.19e-08592
corpus striatum1.53e-074
striatum1.53e-074
ventral part of telencephalon1.53e-074
future corpus striatum1.53e-074
organ1.97e-07503
epithelium4.29e-07306
cell layer7.32e-07309


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.12.45009
MA0017.10.577281
MA0019.13.35236
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.12.83685
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.11.9583
MA0101.10.539569
MA0103.11.29536
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.912459
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.11.37853
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.72671
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00818922779447613
MYC#460945.22228187160940.001344309395272740.00888878309166758
ZNF263#1012736.166381227758010.006539814347975980.0279853999298641



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.