Coexpression cluster:C2593

Full id: C2593_heart_thyroid_retina_left_umbilical_smooth_pituitary

Phase1 CAGE Peaks

Hg19::chr1:55013889..55013912,+	p1@ACOT11
Hg19::chr1:55013918..55013934,+	p3@ACOT11
Hg19::chr4:186733169..186733170,-	p29@SORBS2
Hg19::chr4:186733332..186733356,-	p5@SORBS2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016291	acyl-CoA thioesterase activity	0.0164969859543486
GO:0016289	CoA hydrolase activity	0.0164969859543486
GO:0009266	response to temperature stimulus	0.0164969859543486
GO:0009628	response to abiotic stimulus	0.0464543083416553
GO:0016790	thiolester hydrolase activity	0.0464543083416553
GO:0004091	carboxylesterase activity	0.0464543083416553
GO:0006631	fatty acid metabolic process	0.0464543083416553

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	4.19e-47	115
regional part of nervous system	8.52e-36	94
nervous system	8.52e-36	94
central nervous system	2.85e-34	82
neural tube	1.79e-32	57
neural rod	1.79e-32	57
future spinal cord	1.79e-32	57
neural keel	1.79e-32	57
brain	5.89e-31	69
future brain	5.89e-31	69
regional part of brain	2.07e-30	59
neural plate	1.44e-29	86
presumptive neural plate	1.44e-29	86
neurectoderm	7.29e-29	90
regional part of forebrain	1.59e-26	41
forebrain	1.59e-26	41
future forebrain	1.59e-26	41
anterior region of body	1.12e-25	129
craniocervical region	1.12e-25	129
anterior neural tube	2.50e-25	42
head	3.66e-25	123
ectoderm-derived structure	7.45e-23	169
ectoderm	9.58e-23	173
presumptive ectoderm	9.58e-23	173
pre-chordal neural plate	1.31e-22	61
telencephalon	5.74e-22	34
gray matter	9.01e-22	34
brain grey matter	9.01e-22	34
regional part of telencephalon	2.88e-21	33
cerebral hemisphere	5.14e-21	32
multi-tissue structure	5.70e-18	347
cerebral cortex	2.51e-16	25
pallium	2.51e-16	25
regional part of cerebral cortex	2.04e-15	22
organ	2.50e-14	511
neocortex	3.74e-14	20
organism subdivision	9.67e-14	365
embryo	1.83e-13	612
multi-cellular organism	2.30e-12	659
embryonic structure	2.62e-12	605
developing anatomical structure	2.62e-12	605
germ layer	5.48e-12	604
embryonic tissue	5.48e-12	604
presumptive structure	5.48e-12	604
epiblast (generic)	5.48e-12	604
anatomical cluster	1.76e-10	286
anatomical system	1.77e-10	625
tube	2.05e-10	194
anatomical group	2.61e-10	626
cell layer	3.01e-10	312
anatomical conduit	3.01e-10	241
epithelium	4.43e-10	309
posterior neural tube	2.88e-08	15
chordal neural plate	2.88e-08	15
organ part	2.96e-07	219
basal ganglion	3.35e-07	9
nuclear complex of neuraxis	3.35e-07	9
aggregate regional part of brain	3.35e-07	9
collection of basal ganglia	3.35e-07	9
cerebral subcortex	3.35e-07	9
segmental subdivision of nervous system	4.45e-07	13
nucleus of brain	6.73e-07	9
neural nucleus	6.73e-07	9
tissue	7.68e-07	787

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
USF1#7391	4	6.36149927720796	0.000610501139914083	0.00508291841131114

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.