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Coexpression cluster:C3369: Difference between revisions

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|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321120138485501!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0319636667900087!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167114893827268!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0293687628071353!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0189811105420284
|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321120138485501!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0319636667900087!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167114893827268!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0293687628071353!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0189811105420284
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}}
}}

Revision as of 16:05, 26 November 2012


Full id: C3369_peripheral_thyroid_medulloblastoma_argyrophil_neuroblastoma_Adipocyte_neuroectodermal



Phase1 CAGE Peaks

Hg19::chr13:37494248..37494260,-p3@SMAD9
Hg19::chr13:37494275..37494304,-p2@SMAD9
Hg19::chr13:37494306..37494324,-p4@SMAD9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism1.92e-27114
neurectoderm7.12e-2486
nervous system9.13e-2389
neural plate3.23e-2182
presumptive neural plate3.23e-2182
neural tube6.71e-2156
neural rod6.71e-2156
future spinal cord6.71e-2156
neural keel6.71e-2156
central nervous system1.87e-2081
regional part of nervous system6.72e-1953
regional part of brain6.72e-1953
anatomical cluster7.93e-18373
brain5.80e-1768
future brain5.80e-1768
structure with developmental contribution from neural crest9.62e-17132
organ system subdivision4.11e-16223
ectoderm-derived structure3.46e-14171
ectoderm3.46e-14171
presumptive ectoderm3.46e-14171
ecto-epithelium3.98e-14104
regional part of forebrain7.69e-1441
forebrain7.69e-1441
anterior neural tube7.69e-1441
future forebrain7.69e-1441
pre-chordal neural plate1.21e-1361
multi-tissue structure1.60e-12342
telencephalon8.63e-1234
brain grey matter8.90e-1234
gray matter8.90e-1234
multi-cellular organism2.17e-11656
epithelium9.40e-11306
regional part of telencephalon9.44e-1132
cerebral hemisphere1.52e-1032
cell layer3.21e-10309
tube3.24e-10192
cerebral cortex3.70e-0925
pallium3.70e-0925
anatomical conduit4.43e-09240
regional part of cerebral cortex1.11e-0822
posterior neural tube1.57e-0815
chordal neural plate1.57e-0815
neocortex1.00e-0720
developing anatomical structure3.35e-07581
germ layer3.94e-07560
germ layer / neural crest3.94e-07560
embryonic tissue3.94e-07560
presumptive structure3.94e-07560
germ layer / neural crest derived structure3.94e-07560
epiblast (generic)3.94e-07560
embryo4.34e-07592
anatomical system5.49e-07624
embryonic structure5.58e-07564
segmental subdivision of nervous system5.88e-0713
anatomical group7.28e-07625
Disease
Ontology termp-valuen
neuroectodermal tumor2.23e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321120138485501
EGR1#195834.988179094810140.008056488137383440.0319636667900087
EP300#203336.77394172622320.003216880500103790.0167114893827268
MYC#460935.22228187160940.007020843755740150.0293687628071353
USF1#739136.361499277207960.00388404057290560.0189811105420284



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.