Coexpression cluster:C927

Full id: C927_Lens_gall_Ciliary_mesodermal_Fibroblast_Meningeal_cholangiocellular

Phase1 CAGE Peaks

Hg19::chr1:12416343..12416350,+	p@chr1:12416343..12416350 +
Hg19::chr1:218519119..218519130,+	p16@TGFB2
Hg19::chr1:218519150..218519159,+	p20@TGFB2
Hg19::chr1:218519166..218519227,+	p4@TGFB2
Hg19::chr1:218519393..218519489,+	p2@TGFB2
Hg19::chr1:218519541..218519558,+	p14@TGFB2
Hg19::chr1:218519582..218519594,+	p8@TGFB2
Hg19::chr1:218519607..218519630,+	p5@TGFB2
Hg19::chr1:218519642..218519668,+	p3@TGFB2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
vascular associated smooth muscle cell	7.43e-09	32
non-terminally differentiated cell	7.63e-09	180
smooth muscle cell	2.08e-07	42
smooth muscle myoblast	2.08e-07	42
contractile cell	3.12e-07	59

Uber Anatomy

Ontology term	p-value	n
multi-tissue structure	3.03e-30	347
anatomical cluster	3.77e-29	286
cell layer	7.08e-28	312
organism subdivision	1.69e-27	365
epithelium	1.93e-26	309
anatomical conduit	1.61e-25	241
head	2.26e-24	123
ectoderm-derived structure	6.77e-23	169
anterior region of body	2.29e-22	129
craniocervical region	2.29e-22	129
ectoderm	3.24e-22	173
presumptive ectoderm	3.24e-22	173
tube	5.99e-21	194
multi-cellular organism	4.65e-20	659
neural plate	6.92e-20	86
presumptive neural plate	6.92e-20	86
central nervous system	1.16e-19	82
regional part of nervous system	2.32e-19	94
nervous system	2.32e-19	94
neurectoderm	8.47e-19	90
brain	1.34e-18	69
future brain	1.34e-18	69
regional part of brain	2.58e-17	59
embryonic structure	3.97e-17	605
developing anatomical structure	3.97e-17	605
anatomical system	4.11e-17	625
embryo	4.25e-17	612
anatomical group	6.39e-17	626
germ layer	9.44e-17	604
embryonic tissue	9.44e-17	604
presumptive structure	9.44e-17	604
epiblast (generic)	9.44e-17	604
neural tube	7.37e-16	57
neural rod	7.37e-16	57
future spinal cord	7.37e-16	57
neural keel	7.37e-16	57
pre-chordal neural plate	2.43e-14	61
organ part	2.18e-12	219
regional part of forebrain	1.95e-11	41
forebrain	1.95e-11	41
future forebrain	1.95e-11	41
gray matter	2.14e-11	34
brain grey matter	2.14e-11	34
anterior neural tube	2.81e-11	42
telencephalon	3.19e-11	34
organ	3.41e-11	511
regional part of telencephalon	5.00e-11	33
cerebral hemisphere	7.89e-11	32
trunk mesenchyme	8.91e-10	143
adult organism	1.34e-09	115
mesenchyme	3.53e-09	238
entire embryonic mesenchyme	3.53e-09	238
cerebral cortex	3.72e-09	25
pallium	3.72e-09	25
vasculature	4.57e-09	79
vascular system	4.57e-09	79
trunk	6.95e-09	216
epithelial tube	2.44e-08	118
regional part of cerebral cortex	9.59e-08	22
primordium	2.88e-07	168
somite	3.34e-07	83
paraxial mesoderm	3.34e-07	83
presomitic mesoderm	3.34e-07	83
presumptive segmental plate	3.34e-07	83
trunk paraxial mesoderm	3.34e-07	83
presumptive paraxial mesoderm	3.34e-07	83
cardiovascular system	3.52e-07	110
vasculature of head	4.15e-07	11
vasculature of organ	4.15e-07	11
skeletal muscle tissue	4.67e-07	61
striated muscle tissue	4.67e-07	61
myotome	4.67e-07	61
neocortex	4.73e-07	20
muscle tissue	4.83e-07	63
musculature	4.83e-07	63
musculature of body	4.83e-07	63
circulatory system	6.26e-07	113

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTBP2#1488	3	20.905666779776	0.000316544236772394	0.00324240521226678
CTCF#10664	8	4.76467233162225	1.10088565904027e-05	0.000284874621765378
E2F1#1869	8	4.3621237465594	2.18983367577486e-05	0.000481178285849465
E2F6#1876	7	3.90223223576463	0.000306742359949273	0.00316309886756933
POLR2A#5430	8	1.90884726805162	0.011661228959883	0.0425864428051338
SMARCB1#6598	8	16.2246362499177	6.9314124393577e-10	6.59899529402077e-08
ZNF263#10127	8	7.30830367734282	3.84008362723504e-07	1.87496257103693e-05

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.