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Coexpression cluster:C1237: Difference between revisions

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|gostat_on_coexpression_clusters=GO:0046982!protein heterodimerization activity!0.0432414929942305!6925$GO:0003714!transcription corepressor activity!0.0432414929942305!6925$GO:0000122!negative regulation of transcription from RNA polymerase II promoter!0.0432414929942305!6925$GO:0045892!negative regulation of transcription, DNA-dependent!0.0432414929942305!6925$GO:0005667!transcription factor complex!0.0432414929942305!6925$GO:0016564!transcription repressor activity!0.0432414929942305!6925$GO:0045893!positive regulation of transcription, DNA-dependent!0.0432414929942305!6925$GO:0045941!positive regulation of transcription!0.0432414929942305!6925$GO:0045935!positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0432414929942305!6925$GO:0016481!negative regulation of transcription!0.0432414929942305!6925$GO:0003712!transcription cofactor activity!0.0432414929942305!6925$GO:0045934!negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0432414929942305!6925$GO:0031325!positive regulation of cellular metabolic process!0.0432414929942305!6925$GO:0046983!protein dimerization activity!0.0432414929942305!6925$GO:0031324!negative regulation of cellular metabolic process!0.0432414929942305!6925$GO:0009893!positive regulation of metabolic process!0.0432414929942305!6925$GO:0006357!regulation of transcription from RNA polymerase II promoter!0.0432414929942305!6925$GO:0008134!transcription factor binding!0.0432414929942305!6925$GO:0009892!negative regulation of metabolic process!0.0432414929942305!6925$GO:0044451!nucleoplasm part!0.0432414929942305!6925$GO:0005654!nucleoplasm!0.0472868412642344!6925
|gostat_on_coexpression_clusters=GO:0046982!protein heterodimerization activity!0.0432414929942305!6925$GO:0003714!transcription corepressor activity!0.0432414929942305!6925$GO:0000122!negative regulation of transcription from RNA polymerase II promoter!0.0432414929942305!6925$GO:0045892!negative regulation of transcription, DNA-dependent!0.0432414929942305!6925$GO:0005667!transcription factor complex!0.0432414929942305!6925$GO:0016564!transcription repressor activity!0.0432414929942305!6925$GO:0045893!positive regulation of transcription, DNA-dependent!0.0432414929942305!6925$GO:0045941!positive regulation of transcription!0.0432414929942305!6925$GO:0045935!positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0432414929942305!6925$GO:0016481!negative regulation of transcription!0.0432414929942305!6925$GO:0003712!transcription cofactor activity!0.0432414929942305!6925$GO:0045934!negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0432414929942305!6925$GO:0031325!positive regulation of cellular metabolic process!0.0432414929942305!6925$GO:0046983!protein dimerization activity!0.0432414929942305!6925$GO:0031324!negative regulation of cellular metabolic process!0.0432414929942305!6925$GO:0009893!positive regulation of metabolic process!0.0432414929942305!6925$GO:0006357!regulation of transcription from RNA polymerase II promoter!0.0432414929942305!6925$GO:0008134!transcription factor binding!0.0432414929942305!6925$GO:0009892!negative regulation of metabolic process!0.0432414929942305!6925$GO:0044451!nucleoplasm part!0.0432414929942305!6925$GO:0005654!nucleoplasm!0.0472868412642344!6925
|id=C1237
|id=C1237
|ontology_enrichment_celltype=CL:0000222!7.92e-20!119;CL:0002139!4.52e-18!24;CL:0000115!1.70e-15!35;CL:0000071!5.30e-14!18;CL:0002546!5.30e-14!18;CL:0000213!1.73e-13!57;CL:0000215!1.73e-13!57;CL:0002078!4.18e-13!44;CL:0000055!1.18e-10!180;CL:0000680!5.77e-09!57;CL:0000056!5.77e-09!57;CL:0000355!5.77e-09!57;CL:0000187!1.35e-08!54;CL:0000393!4.11e-08!60;CL:0000211!4.11e-08!60;CL:1000413!8.13e-08!9;CL:0000183!1.42e-07!59;CL:0000192!4.80e-07!42;CL:0000514!4.80e-07!42
|ontology_enrichment_celltype=CL:0002139!2.67e-24!24;CL:0000115!9.22e-21!36;CL:0000071!5.93e-19!18;CL:0002546!5.93e-19!18;CL:0002078!1.28e-17!45;CL:0000213!6.60e-13!58;CL:0000215!6.60e-13!58;CL:0000222!1.25e-12!121;CL:1000413!2.54e-10!9;CL:0002544!1.88e-07!6;CL:0002543!1.92e-07!6;CL:0005020!6.73e-07!6;CL:0002138!6.73e-07!6;CL:0005022!6.73e-07!6
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000025!1.24e-30!194;UBERON:0004111!2.29e-28!241;UBERON:0004872!1.88e-26!84;UBERON:0000477!1.20e-25!286;UBERON:0007023!4.16e-25!115;UBERON:0000055!4.48e-25!69;UBERON:0002049!2.37e-24!79;UBERON:0007798!2.37e-24!79;UBERON:0001981!2.44e-22!60;UBERON:0007500!2.44e-22!60;UBERON:0004537!2.44e-22!60;UBERON:0006965!2.44e-22!60;UBERON:0000483!2.92e-22!309;UBERON:0000119!3.01e-22!312;UBERON:0001009!2.65e-20!113;UBERON:0000073!2.47e-19!94;UBERON:0001016!2.47e-19!94;UBERON:0004535!2.52e-19!110;UBERON:0001017!5.10e-19!82;UBERON:0005743!1.35e-18!86;UBERON:0001049!1.92e-18!57;UBERON:0005068!1.92e-18!57;UBERON:0006241!1.92e-18!57;UBERON:0007135!1.92e-18!57;UBERON:0002616!4.67e-17!59;UBERON:0000955!5.51e-17!69;UBERON:0006238!5.51e-17!69;UBERON:0003914!1.08e-16!118;UBERON:0000475!1.61e-16!365;UBERON:0003080!7.03e-16!42;UBERON:0000468!1.99e-15!659;UBERON:0002780!2.62e-15!41;UBERON:0001890!2.62e-15!41;UBERON:0006240!2.62e-15!41;UBERON:0003075!3.87e-15!86;UBERON:0007284!3.87e-15!86;UBERON:0002346!1.00e-14!90;UBERON:0001893!3.23e-14!34;UBERON:0001986!5.30e-14!18;UBERON:0004638!5.30e-14!18;UBERON:0004852!5.30e-14!18;UBERON:0002020!8.65e-14!34;UBERON:0003528!8.65e-14!34;UBERON:0002791!1.01e-13!33;UBERON:0001869!1.25e-13!32;UBERON:0001637!1.38e-13!42;UBERON:0003509!1.38e-13!42;UBERON:0004572!1.38e-13!42;UBERON:0000467!1.90e-12!625;UBERON:0000480!3.14e-12!626;UBERON:0000487!3.47e-12!22;UBERON:0006914!4.06e-12!25;UBERON:0000490!6.49e-12!138;UBERON:0000956!1.05e-11!25;UBERON:0000203!1.05e-11!25;UBERON:0004573!2.90e-11!33;UBERON:0004571!2.90e-11!33;UBERON:0003056!8.13e-11!61;UBERON:0000481!9.23e-11!347;UBERON:0002385!9.77e-11!63;UBERON:0001015!9.77e-11!63;UBERON:0000383!9.77e-11!63;UBERON:0001134!1.99e-10!61;UBERON:0002036!1.99e-10!61;UBERON:0003082!1.99e-10!61;UBERON:0002619!2.18e-10!22;UBERON:0004290!1.05e-09!70;UBERON:0000947!1.44e-09!21;UBERON:0010191!1.44e-09!21;UBERON:0001950!1.63e-09!20;UBERON:0007100!3.10e-08!27;UBERON:0003915!8.13e-08!9;UBERON:0004700!8.13e-08!9;UBERON:0001917!8.13e-08!9;UBERON:0000948!2.66e-07!24;UBERON:0005498!2.66e-07!24;UBERON:0004140!2.66e-07!24;UBERON:0009881!2.66e-07!24;UBERON:0004141!2.66e-07!24;UBERON:0003084!2.66e-07!24;UBERON:0007005!2.66e-07!24;UBERON:0004139!2.66e-07!24;UBERON:0004291!2.66e-07!24;UBERON:0000914!5.15e-07!83;UBERON:0002329!5.15e-07!83;UBERON:0003077!5.15e-07!83;UBERON:0003059!5.15e-07!83;UBERON:0007282!5.15e-07!83;UBERON:0009618!5.15e-07!83;UBERON:0007285!5.15e-07!83;UBERON:0000486!7.79e-07!82;UBERON:0000153!7.89e-07!129;UBERON:0007811!7.89e-07!129;UBERON:0000033!9.98e-07!123
|ontology_enrichment_uberon=UBERON:0000025!1.21e-27!192;UBERON:0007023!6.29e-26!114;UBERON:0004111!5.62e-25!240;UBERON:0000477!1.27e-23!373;UBERON:0000055!3.14e-23!68;UBERON:0004872!4.82e-21!83;UBERON:0007500!1.86e-20!59;UBERON:0001981!1.86e-20!59;UBERON:0004537!1.86e-20!59;UBERON:0006965!1.86e-20!59;UBERON:0002049!2.97e-20!78;UBERON:0007798!2.97e-20!78;UBERON:0004638!5.93e-19!18;UBERON:0001986!5.93e-19!18;UBERON:0004852!5.93e-19!18;UBERON:0001009!5.53e-17!112;UBERON:0000483!1.44e-16!306;UBERON:0000119!5.10e-16!309;UBERON:0001049!6.66e-16!56;UBERON:0005068!6.66e-16!56;UBERON:0006241!6.66e-16!56;UBERON:0007135!6.66e-16!56;UBERON:0004535!6.98e-16!109;UBERON:0001017!8.32e-16!81;UBERON:0003914!6.56e-15!117;UBERON:0000468!7.08e-15!656;UBERON:0001016!7.82e-15!89;UBERON:0001893!1.02e-14!34;UBERON:0000955!1.04e-14!68;UBERON:0006238!1.04e-14!68;UBERON:0003528!1.56e-14!34;UBERON:0002020!1.56e-14!34;UBERON:0002780!2.33e-14!41;UBERON:0001890!2.33e-14!41;UBERON:0003080!2.33e-14!41;UBERON:0006240!2.33e-14!41;UBERON:0000073!2.42e-14!53;UBERON:0002616!2.42e-14!53;UBERON:0000487!5.07e-14!22;UBERON:0001869!5.27e-14!32;UBERON:0002791!1.56e-13!32;UBERON:0006914!5.62e-13!25;UBERON:0002346!3.57e-12!86;UBERON:0003075!9.65e-12!82;UBERON:0007284!9.65e-12!82;UBERON:0001637!3.86e-11!42;UBERON:0003509!3.86e-11!42;UBERON:0004572!3.86e-11!42;UBERON:0000467!1.35e-10!624;UBERON:0000956!1.36e-10!25;UBERON:0000203!1.36e-10!25;UBERON:0000480!1.75e-10!625;UBERON:0010314!2.53e-10!132;UBERON:0003915!2.54e-10!9;UBERON:0004700!2.54e-10!9;UBERON:0001917!2.54e-10!9;UBERON:0000947!3.41e-10!21;UBERON:0010191!3.41e-10!21;UBERON:0004573!1.67e-09!33;UBERON:0004571!1.67e-09!33;UBERON:0003056!6.08e-09!61;UBERON:0001950!6.51e-09!20;UBERON:0002619!1.07e-08!22;UBERON:0000481!4.62e-08!342;UBERON:0000923!6.51e-08!560;UBERON:0010316!6.51e-08!560;UBERON:0005291!6.51e-08!560;UBERON:0006598!6.51e-08!560;UBERON:0010317!6.51e-08!560;UBERON:0002532!6.51e-08!560;UBERON:0002050!7.37e-08!564;UBERON:0001638!1.43e-07!9;UBERON:0003920!1.43e-07!9;UBERON:0004582!1.43e-07!9;UBERON:0000490!2.39e-07!148;UBERON:0005423!3.43e-07!581;UBERON:0011216!6.60e-07!223;UBERON:0010371!7.70e-07!104;UBERON:0000922!7.78e-07!592
|tf_chipseq_enrich=EP300#2033;4:3.87082384355611:0.0114256758668448:0.0418623456185722!FOS#2353;5:6.42711093492458:0.000293119596542414:0.00310824627305241!GATA2#2624;5:9.10352266682428:5.45256227113712e-05:0.00092384839557964!GATA3#2625;4:15.5637236326891:5.8119493323542e-05:0.000966859153108856!JUN#3725;5:8.9377351373831:5.96198127192225e-05:0.000984603671818925!POLR2A#5430;7:2.14745317655807:0.00474763644761028:0.0223471427326469!SUZ12#23512;2:14.318794546018:0.00781968192361486:0.03211986786834
|tf_chipseq_enrich=EP300#2033;4:3.87082384355611:0.0114256758668448:0.0418623456185722!FOS#2353;5:6.42711093492458:0.000293119596542414:0.00310824627305241!GATA2#2624;5:9.10352266682428:5.45256227113712e-05:0.00092384839557964!GATA3#2625;4:15.5637236326891:5.8119493323542e-05:0.000966859153108856!JUN#3725;5:8.9377351373831:5.96198127192225e-05:0.000984603671818925!POLR2A#5430;7:2.14745317655807:0.00474763644761028:0.0223471427326469!SUZ12#23512;2:14.318794546018:0.00781968192361486:0.03211986786834
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}}
}}

Revision as of 11:01, 19 October 2012


Full id: C1237_Endothelial_Preadipocyte_Lymphatic_Renal_lung_heart_skin



Phase1 CAGE Peaks

Hg19::chr18:53068893..53068902,-p28@TCF4
Hg19::chr18:53068911..53068935,-p4@TCF4
Hg19::chr18:53068940..53068951,-p21@TCF4
Hg19::chr18:53068982..53068993,-p20@TCF4
Hg19::chr2:225266779..225266786,-p4@FAM124B
Hg19::chr2:56412876..56412892,-p3@ENST00000432793
p3@uc010fca.1
Hg19::chr2:56412925..56412945,-p2@ENST00000432793
p2@uc010fca.1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0046982protein heterodimerization activity0.0432414929942305
GO:0003714transcription corepressor activity0.0432414929942305
GO:0000122negative regulation of transcription from RNA polymerase II promoter0.0432414929942305
GO:0045892negative regulation of transcription, DNA-dependent0.0432414929942305
GO:0005667transcription factor complex0.0432414929942305
GO:0016564transcription repressor activity0.0432414929942305
GO:0045893positive regulation of transcription, DNA-dependent0.0432414929942305
GO:0045941positive regulation of transcription0.0432414929942305
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0432414929942305
GO:0016481negative regulation of transcription0.0432414929942305
GO:0003712transcription cofactor activity0.0432414929942305
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0432414929942305
GO:0031325positive regulation of cellular metabolic process0.0432414929942305
GO:0046983protein dimerization activity0.0432414929942305
GO:0031324negative regulation of cellular metabolic process0.0432414929942305
GO:0009893positive regulation of metabolic process0.0432414929942305
GO:0006357regulation of transcription from RNA polymerase II promoter0.0432414929942305
GO:0008134transcription factor binding0.0432414929942305
GO:0009892negative regulation of metabolic process0.0432414929942305
GO:0044451nucleoplasm part0.0432414929942305
GO:0005654nucleoplasm0.0472868412642344



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
tube1.21e-27192
adult organism6.29e-26114
anatomical conduit5.62e-25240
anatomical cluster1.27e-23373
vessel3.14e-2368
splanchnic layer of lateral plate mesoderm4.82e-2183
epithelial tube open at both ends1.86e-2059
blood vessel1.86e-2059
blood vasculature1.86e-2059
vascular cord1.86e-2059
vasculature2.97e-2078
vascular system2.97e-2078
blood vessel endothelium5.93e-1918
endothelium5.93e-1918
cardiovascular system endothelium5.93e-1918
circulatory system5.53e-17112
epithelium1.44e-16306
cell layer5.10e-16309
neural tube6.66e-1656
neural rod6.66e-1656
future spinal cord6.66e-1656
neural keel6.66e-1656
cardiovascular system6.98e-16109
central nervous system8.32e-1681
epithelial tube6.56e-15117
multi-cellular organism7.08e-15656
nervous system7.82e-1589
telencephalon1.02e-1434
brain1.04e-1468
future brain1.04e-1468
brain grey matter1.56e-1434
gray matter1.56e-1434
regional part of forebrain2.33e-1441
forebrain2.33e-1441
anterior neural tube2.33e-1441
future forebrain2.33e-1441
regional part of nervous system2.42e-1453
regional part of brain2.42e-1453
simple squamous epithelium5.07e-1422
cerebral hemisphere5.27e-1432
regional part of telencephalon1.56e-1332
squamous epithelium5.62e-1325
neurectoderm3.57e-1286
neural plate9.65e-1282
presumptive neural plate9.65e-1282
artery3.86e-1142
arterial blood vessel3.86e-1142
arterial system3.86e-1142
anatomical system1.35e-10624
cerebral cortex1.36e-1025
pallium1.36e-1025
anatomical group1.75e-10625
structure with developmental contribution from neural crest2.53e-10132
endothelial tube2.54e-109
arterial system endothelium2.54e-109
endothelium of artery2.54e-109
aorta3.41e-1021
aortic system3.41e-1021
systemic artery1.67e-0933
systemic arterial system1.67e-0933
pre-chordal neural plate6.08e-0961
neocortex6.51e-0920
regional part of cerebral cortex1.07e-0822
multi-tissue structure4.62e-08342
germ layer6.51e-08560
germ layer / neural crest6.51e-08560
embryonic tissue6.51e-08560
presumptive structure6.51e-08560
germ layer / neural crest derived structure6.51e-08560
epiblast (generic)6.51e-08560
embryonic structure7.37e-08564
vein1.43e-079
venous blood vessel1.43e-079
venous system1.43e-079
unilaminar epithelium2.39e-07148
developing anatomical structure3.43e-07581
organ system subdivision6.60e-07223
ecto-epithelium7.70e-07104
embryo7.78e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203343.870823843556110.01142567586684480.0418623456185722
FOS#235356.427110934924580.0002931195965424140.00310824627305241
GATA2#262459.103522666824285.45256227113712e-050.00092384839557964
GATA3#2625415.56372363268915.8119493323542e-050.000966859153108856
JUN#372558.93773513738315.96198127192225e-050.000984603671818925
POLR2A#543072.147453176558070.004747636447610280.0223471427326469
SUZ12#23512214.3187945460180.007819681923614860.03211986786834



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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