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Coexpression cluster:C4000: Difference between revisions

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|full_id=C4000_olfactory_Hepatocyte_small_brain_insula_temporal_nucleus
|full_id=C4000_olfactory_Hepatocyte_small_brain_insula_temporal_nucleus
|id=C4000
|id=C4000
|ontology_enrichment_celltype=CL:0002321!2.33e-08!248;CL:0000055!2.59e-08!180;CL:0000220!3.10e-08!246;CL:0000222!1.56e-07!119;CL:0000066!8.91e-07!254
|ontology_enrichment_celltype=CL:0002321!5.49e-07!250;CL:0000222!7.68e-07!121
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000119!1.12e-34!312;UBERON:0000481!4.93e-34!347;UBERON:0000483!8.13e-34!309;UBERON:0000477!4.32e-33!286;UBERON:0000475!2.65e-32!365;UBERON:0004111!1.39e-31!241;UBERON:0000025!6.60e-29!194;UBERON:0005743!6.04e-28!86;UBERON:0001017!8.96e-28!82;UBERON:0000073!9.74e-27!94;UBERON:0001016!9.74e-27!94;UBERON:0001049!1.76e-26!57;UBERON:0005068!1.76e-26!57;UBERON:0006241!1.76e-26!57;UBERON:0007135!1.76e-26!57;UBERON:0003075!8.25e-26!86;UBERON:0007284!8.25e-26!86;UBERON:0002616!1.49e-24!59;UBERON:0002346!8.97e-24!90;UBERON:0000955!9.95e-24!69;UBERON:0006238!9.95e-24!69;UBERON:0000033!5.20e-23!123;UBERON:0000468!4.66e-22!659;UBERON:0002780!1.65e-21!41;UBERON:0001890!1.65e-21!41;UBERON:0006240!1.65e-21!41;UBERON:0000467!2.07e-21!625;UBERON:0000480!2.65e-21!626;UBERON:0004121!3.39e-21!169;UBERON:0001893!6.49e-21!34;UBERON:0003080!7.06e-21!42;UBERON:0000153!9.75e-21!129;UBERON:0007811!9.75e-21!129;UBERON:0002020!1.08e-20!34;UBERON:0003528!1.08e-20!34;UBERON:0001869!2.07e-20!32;UBERON:0002791!3.11e-20!33;UBERON:0003056!3.53e-20!61;UBERON:0000924!4.23e-20!173;UBERON:0006601!4.23e-20!173;UBERON:0000922!4.39e-18!612;UBERON:0000064!1.51e-16!219;UBERON:0002050!1.97e-16!605;UBERON:0005423!1.97e-16!605;UBERON:0000956!2.15e-16!25;UBERON:0000203!2.15e-16!25;UBERON:0000923!3.34e-16!604;UBERON:0005291!3.34e-16!604;UBERON:0006598!3.34e-16!604;UBERON:0002532!3.34e-16!604;UBERON:0002619!8.88e-15!22;UBERON:0001950!1.79e-13!20;UBERON:0000062!3.77e-13!511;UBERON:0007023!4.59e-13!115;UBERON:0005256!8.12e-11!143;UBERON:0002100!1.74e-10!216;UBERON:0003104!3.79e-10!238;UBERON:0009142!3.79e-10!238;UBERON:0000490!2.32e-09!138;UBERON:0003914!2.69e-08!118;UBERON:0001007!5.22e-08!155;UBERON:0001555!5.22e-08!155;UBERON:0007026!5.22e-08!155;UBERON:0003076!7.82e-07!15;UBERON:0003057!7.82e-07!15
|ontology_enrichment_uberon=UBERON:0000477!6.39e-40!373;UBERON:0000481!1.24e-32!342;UBERON:0000119!1.13e-29!309;UBERON:0000483!6.11e-29!306;UBERON:0004111!9.71e-29!240;UBERON:0001017!2.73e-27!81;UBERON:0011216!7.16e-27!223;UBERON:0001049!1.12e-25!56;UBERON:0005068!1.12e-25!56;UBERON:0006241!1.12e-25!56;UBERON:0007135!1.12e-25!56;UBERON:0000025!3.09e-25!192;UBERON:0010314!3.14e-25!132;UBERON:0001016!3.74e-25!89;UBERON:0000073!1.70e-24!53;UBERON:0002616!1.70e-24!53;UBERON:0003075!4.60e-24!82;UBERON:0007284!4.60e-24!82;UBERON:0000955!9.95e-24!68;UBERON:0006238!9.95e-24!68;UBERON:0002346!3.26e-22!86;UBERON:0002780!2.02e-20!41;UBERON:0001890!2.02e-20!41;UBERON:0003080!2.02e-20!41;UBERON:0006240!2.02e-20!41;UBERON:0001893!3.71e-20!34;UBERON:0003528!6.15e-20!34;UBERON:0002020!6.15e-20!34;UBERON:0001869!6.31e-20!32;UBERON:0003056!2.97e-19!61;UBERON:0002791!5.69e-19!32;UBERON:0000468!6.15e-19!656;UBERON:0000467!1.81e-18!624;UBERON:0000480!2.17e-18!625;UBERON:0004121!2.64e-18!171;UBERON:0000924!2.64e-18!171;UBERON:0006601!2.64e-18!171;UBERON:0010371!5.39e-17!104;UBERON:0000956!5.45e-16!25;UBERON:0000203!5.45e-16!25;UBERON:0002619!1.11e-14!22;UBERON:0000064!2.74e-14!218;UBERON:0000922!9.53e-14!592;UBERON:0001950!2.18e-13!20;UBERON:0005423!2.26e-12!581;UBERON:0007023!3.56e-12!114;UBERON:0000923!2.14e-10!560;UBERON:0010316!2.14e-10!560;UBERON:0005291!2.14e-10!560;UBERON:0006598!2.14e-10!560;UBERON:0010317!2.14e-10!560;UBERON:0002532!2.14e-10!560;UBERON:0002050!2.69e-10!564;UBERON:0000475!2.70e-10!264;UBERON:0000062!3.80e-10!503;UBERON:0003104!6.71e-10!160;UBERON:0009142!6.71e-10!160;UBERON:0000490!7.99e-10!148;UBERON:0005256!2.04e-08!122;UBERON:0002100!1.05e-07!199;UBERON:0001007!2.28e-07!145;UBERON:0001555!2.28e-07!145;UBERON:0007026!2.28e-07!145
|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00660925190521738!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325772110112566!ZBTB33#10009;3:31.6647250299812:3.14815888737575e-05:0.000634118738743753
|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00660925190521738!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325772110112566!ZBTB33#10009;3:31.6647250299812:3.14815888737575e-05:0.000634118738743753
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27622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.171683,0.158847,2.03384e-05,0.071111,0.270604,0.101021,0.222548,0.175934,0.157274,0.215705,0.035048,0.205954,0.361435
}}
}}

Revision as of 15:35, 19 October 2012


Full id: C4000_olfactory_Hepatocyte_small_brain_insula_temporal_nucleus



Phase1 CAGE Peaks

Hg19::chr1:85930541..85930595,-p13@DDAH1
Hg19::chr1:85930830..85930858,-p1@DDAH1
Hg19::chr1:85930883..85930894,-p8@DDAH1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
embryonic cell5.49e-07250
mesodermal cell7.68e-07121
Uber Anatomy
Ontology termp-valuen
anatomical cluster6.39e-40373
multi-tissue structure1.24e-32342
cell layer1.13e-29309
epithelium6.11e-29306
anatomical conduit9.71e-29240
central nervous system2.73e-2781
organ system subdivision7.16e-27223
neural tube1.12e-2556
neural rod1.12e-2556
future spinal cord1.12e-2556
neural keel1.12e-2556
tube3.09e-25192
structure with developmental contribution from neural crest3.14e-25132
nervous system3.74e-2589
regional part of nervous system1.70e-2453
regional part of brain1.70e-2453
neural plate4.60e-2482
presumptive neural plate4.60e-2482
brain9.95e-2468
future brain9.95e-2468
neurectoderm3.26e-2286
regional part of forebrain2.02e-2041
forebrain2.02e-2041
anterior neural tube2.02e-2041
future forebrain2.02e-2041
telencephalon3.71e-2034
brain grey matter6.15e-2034
gray matter6.15e-2034
cerebral hemisphere6.31e-2032
pre-chordal neural plate2.97e-1961
regional part of telencephalon5.69e-1932
multi-cellular organism6.15e-19656
anatomical system1.81e-18624
anatomical group2.17e-18625
ectoderm-derived structure2.64e-18171
ectoderm2.64e-18171
presumptive ectoderm2.64e-18171
ecto-epithelium5.39e-17104
cerebral cortex5.45e-1625
pallium5.45e-1625
regional part of cerebral cortex1.11e-1422
organ part2.74e-14218
embryo9.53e-14592
neocortex2.18e-1320
developing anatomical structure2.26e-12581
adult organism3.56e-12114
germ layer2.14e-10560
germ layer / neural crest2.14e-10560
embryonic tissue2.14e-10560
presumptive structure2.14e-10560
germ layer / neural crest derived structure2.14e-10560
epiblast (generic)2.14e-10560
embryonic structure2.69e-10564
organism subdivision2.70e-10264
organ3.80e-10503
mesenchyme6.71e-10160
entire embryonic mesenchyme6.71e-10160
unilaminar epithelium7.99e-10148
trunk mesenchyme2.04e-08122
trunk1.05e-07199
digestive system2.28e-07145
digestive tract2.28e-07145
primitive gut2.28e-07145


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00660925190521738
E2F1#186934.907389214879320.008460985347239390.0325772110112566
ZBTB33#10009331.66472502998123.14815888737575e-050.000634118738743753



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.