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Coexpression cluster:C1944

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Full id: C1944_Astrocyte_Ciliary_Lens_colon_teratocarcinoma_gastric_Neural



Phase1 CAGE Peaks

  Short description
Hg19::chr4:77356957..77356973,+ p20@SHROOM3
Hg19::chr4:77356989..77357005,+ p12@SHROOM3
Hg19::chr4:77357010..77357040,+ p6@SHROOM3
Hg19::chr4:77357272..77357284,+ p11@SHROOM3
Hg19::chr4:77357318..77357335,+ p10@SHROOM3


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
neural plate2.93e-5882
presumptive neural plate2.93e-5882
neurectoderm7.90e-5586
central nervous system3.50e-5481
neural tube2.01e-4856
neural rod2.01e-4856
future spinal cord2.01e-4856
neural keel2.01e-4856
nervous system2.49e-4789
regional part of nervous system2.17e-4353
regional part of brain2.17e-4353
ecto-epithelium1.19e-42104
brain4.67e-4168
future brain4.67e-4168
structure with developmental contribution from neural crest6.11e-41132
pre-chordal neural plate3.66e-4061
ectoderm-derived structure2.72e-35171
ectoderm2.72e-35171
presumptive ectoderm2.72e-35171
regional part of forebrain1.03e-2941
forebrain1.03e-2941
anterior neural tube1.03e-2941
future forebrain1.03e-2941
telencephalon3.09e-2934
brain grey matter4.57e-2934
gray matter4.57e-2934
cerebral hemisphere7.89e-2932
cerebral cortex2.02e-2625
pallium2.02e-2625
regional part of telencephalon2.65e-2632
regional part of cerebral cortex8.31e-2122
neocortex1.83e-2020
posterior neural tube2.33e-2015
chordal neural plate2.33e-2015
pigment epithelium of eye3.83e-1911
organ system subdivision1.24e-16223
segmental subdivision of hindbrain3.61e-1512
hindbrain3.61e-1512
presumptive hindbrain3.61e-1512
anatomical cluster5.62e-14373
segmental subdivision of nervous system8.02e-1413
adult organism8.98e-13114
brainstem1.36e-116
camera-type eye2.28e-1120
simple eye2.28e-1120
immature eye2.28e-1120
ocular region2.28e-1120
eyeball of camera-type eye2.28e-1120
optic cup2.28e-1120
optic vesicle2.28e-1120
eye primordium2.28e-1120
organ part3.11e-11218
tube1.01e-10192
eye1.08e-1021
visual system1.08e-1021
regional part of metencephalon3.50e-109
metencephalon3.50e-109
future metencephalon3.50e-109
face4.43e-1022
atypical epithelium6.59e-104
epithelium3.08e-09306
sense organ5.19e-0924
sensory system5.19e-0924
entire sense organ system5.19e-0924
cell layer5.24e-09309
gyrus4.70e-086
ciliary epithelium6.03e-083
ciliary body6.03e-083
multi-tissue structure1.09e-07342
anterior segment of eyeball3.17e-0714
pigmented layer of retina3.80e-073
presumptive retinal pigmented epithelium3.80e-073
temporal lobe4.61e-076
spinal cord5.17e-073
dorsal region element5.17e-073
dorsum5.17e-073


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.12.51467
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.11.74614
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.14.00811
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.11.95181
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.994489
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.11.76068
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.12.10746
MA0143.13.11528
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.00207114
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066455.360256373075030.0002259278299937090.0025013968659719



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.