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Coexpression cluster:C2617

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Full id: C2617_brain_occipital_Alveolar_parietal_hippocampus_temporal_left



Phase1 CAGE Peaks

  Short description
Hg19::chr20:36531379..36531393,+ p4@VSTM2L
Hg19::chr20:36531506..36531540,+ p1@VSTM2L
Hg19::chr20:36531547..36531550,+ p3@VSTM2L
Hg19::chr20:36531551..36531561,+ p2@VSTM2L


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
respiratory epithelial cell1.25e-0713
Uber Anatomy
Ontology termp-valuen
neural tube3.64e-3056
neural rod3.64e-3056
future spinal cord3.64e-3056
neural keel3.64e-3056
regional part of nervous system8.29e-3053
regional part of brain8.29e-3053
neurectoderm1.76e-2786
brain2.22e-2668
future brain2.22e-2668
central nervous system5.06e-2681
neural plate9.86e-2682
presumptive neural plate9.86e-2682
ecto-epithelium1.09e-25104
nervous system3.73e-2389
regional part of forebrain4.33e-2341
forebrain4.33e-2341
anterior neural tube4.33e-2341
future forebrain4.33e-2341
cell layer7.44e-23309
epithelium2.12e-22306
ectoderm-derived structure3.59e-22171
ectoderm3.59e-22171
presumptive ectoderm3.59e-22171
telencephalon6.03e-2234
brain grey matter6.81e-2234
gray matter6.81e-2234
cerebral hemisphere7.08e-2232
organ system subdivision3.11e-21223
adult organism6.87e-21114
organ part7.63e-21218
regional part of telencephalon8.39e-2132
pre-chordal neural plate9.27e-2161
structure with developmental contribution from neural crest3.34e-20132
anatomical cluster4.52e-20373
multi-tissue structure8.44e-19342
regional part of cerebral cortex2.01e-1822
cerebral cortex4.15e-1825
pallium4.15e-1825
neocortex5.14e-1720
multi-cellular organism1.60e-16656
embryonic structure1.43e-15564
embryo1.53e-15592
anatomical group2.19e-15625
anatomical system5.33e-15624
anatomical conduit5.91e-15240
developing anatomical structure8.09e-15581
tube8.91e-15192
germ layer1.30e-14560
germ layer / neural crest1.30e-14560
embryonic tissue1.30e-14560
presumptive structure1.30e-14560
germ layer / neural crest derived structure1.30e-14560
epiblast (generic)1.30e-14560
organ7.72e-14503
posterior neural tube3.28e-0815
chordal neural plate3.28e-0815
segmental subdivision of hindbrain6.45e-0812
hindbrain6.45e-0812
presumptive hindbrain6.45e-0812
segmental subdivision of nervous system6.28e-0713


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.15.26462
MA0017.11.41335
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.15.56554
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.380957
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.11.75643
MA0147.10.46175
MA0148.10.739888
MA0149.123.1303
MA0062.20.931615
MA0035.20.778873
MA0039.22.01147
MA0138.22.1393
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.7213
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.12.64806
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.11.78721
MA0161.10
MA0162.13.50007
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.224.8328
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195844.988179094810140.001615011500076050.0101510704174556
TAF1#687243.343046285745290.008005664898701650.0322595739005904
ZNF263#1012748.221841637010680.0002187871180958320.00249208286910356



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.