Coexpression cluster:C4213

Full id: C4213_Placental_Alveolar_Mesenchymal_Endothelial_substantia_optic_Adipocyte

Phase1 CAGE Peaks

Hg19::chr2:242498138..242498179,+	p1@BOK
Hg19::chr2:242498294..242498391,+	p2@BOK
Hg19::chr2:242509651..242509655,+	p@chr2:242509651..242509655 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic cell	4.69e-23	248
mesodermal cell	4.13e-19	119
epithelial cell	9.37e-19	254
lining cell	2.03e-12	57
barrier cell	2.03e-12	57
meso-epithelial cell	2.32e-11	44
endothelial cell of vascular tree	2.59e-11	24
endothelial cell	4.70e-11	35
blood vessel endothelial cell	1.63e-08	18
embryonic blood vessel endothelial progenitor cell	1.63e-08	18
non-terminally differentiated cell	2.70e-08	180
squamous epithelial cell	2.82e-08	62
contractile cell	6.49e-08	59
epithelial cell of nephron	9.00e-08	16

Uber Anatomy

Ontology term	p-value	n
cell layer	4.42e-35	312
epithelium	1.46e-34	309
anatomical conduit	8.03e-33	241
tube	2.51e-31	194
anatomical cluster	9.97e-31	286
organism subdivision	3.18e-29	365
multi-tissue structure	2.59e-20	347
multi-cellular organism	4.79e-20	659
epithelial tube	6.36e-19	118
anatomical system	3.20e-18	625
anatomical group	7.46e-18	626
organ part	2.44e-17	219
trunk	5.11e-15	216
vasculature	5.31e-15	79
vascular system	5.31e-15	79
trunk mesenchyme	1.31e-14	143
unilaminar epithelium	2.95e-14	138
embryo	1.97e-13	612
vessel	2.98e-13	69
neural tube	3.30e-13	57
neural rod	3.30e-13	57
future spinal cord	3.30e-13	57
neural keel	3.30e-13	57
embryonic structure	3.52e-13	605
developing anatomical structure	3.52e-13	605
neural plate	4.24e-13	86
presumptive neural plate	4.24e-13	86
germ layer	4.54e-13	604
embryonic tissue	4.54e-13	604
presumptive structure	4.54e-13	604
epiblast (generic)	4.54e-13	604
regional part of brain	8.77e-13	59
ectoderm-derived structure	7.38e-12	169
head	1.13e-11	123
neurectoderm	2.28e-11	90
splanchnic layer of lateral plate mesoderm	6.75e-11	84
blood vessel	7.35e-11	60
epithelial tube open at both ends	7.35e-11	60
blood vasculature	7.35e-11	60
vascular cord	7.35e-11	60
ectoderm	9.63e-11	173
presumptive ectoderm	9.63e-11	173
brain	1.52e-10	69
future brain	1.52e-10	69
central nervous system	2.84e-10	82
anterior region of body	5.07e-10	129
craniocervical region	5.07e-10	129
regional part of nervous system	8.59e-10	94
nervous system	8.59e-10	94
simple squamous epithelium	2.70e-09	22
pre-chordal neural plate	2.81e-09	61
subdivision of trunk	5.53e-09	113
mesenchyme	5.78e-09	238
entire embryonic mesenchyme	5.78e-09	238
gray matter	7.71e-09	34
brain grey matter	7.71e-09	34
telencephalon	1.36e-08	34
squamous epithelium	1.45e-08	25
endothelium	1.63e-08	18
blood vessel endothelium	1.63e-08	18
cardiovascular system endothelium	1.63e-08	18
anterior neural tube	1.74e-08	42
regional part of telencephalon	2.34e-08	33
regional part of forebrain	4.74e-08	41
forebrain	4.74e-08	41
future forebrain	4.74e-08	41
parenchyma	6.13e-08	17
cardiovascular system	8.64e-08	110
nephron epithelium	9.00e-08	16
nephron	9.00e-08	16
uriniferous tubule	9.00e-08	16
metanephric mesenchyme	9.00e-08	16
nephrogenic mesenchyme	9.00e-08	16
cerebral hemisphere	1.52e-07	32
excretory tube	2.16e-07	17
mesonephric epithelium	2.16e-07	17
mesonephric tubule	2.16e-07	17
nephric duct	2.16e-07	17
kidney epithelium	2.16e-07	17
renal duct	2.16e-07	17
mesonephric duct	2.16e-07	17
pronephric duct	2.16e-07	17
artery	2.54e-07	42
arterial blood vessel	2.54e-07	42

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.