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Coexpression cluster:C3590

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Full id: C3590_teratocarcinoma_medulla_putamen_locus_astrocytoma_retina_caudate



Phase1 CAGE Peaks

Hg19::chr16:77822451..77822469,+p2@VAT1L
Hg19::chr16:77822475..77822492,+p1@VAT1L
Hg19::chr16:77822511..77822522,+p3@VAT1L


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system1.23e-3594
nervous system1.23e-3594
central nervous system2.90e-3382
neural plate2.82e-3286
presumptive neural plate2.82e-3286
neural tube5.06e-3057
neural rod5.06e-3057
future spinal cord5.06e-3057
neural keel5.06e-3057
neurectoderm1.36e-2990
regional part of brain8.13e-2759
brain8.66e-2769
future brain8.66e-2769
tube3.31e-25194
anatomical conduit1.55e-22241
pre-chordal neural plate1.64e-2261
head1.84e-21123
regional part of forebrain6.03e-2141
forebrain6.03e-2141
future forebrain6.03e-2141
anatomical cluster6.31e-21286
ectoderm-derived structure1.01e-20169
adult organism2.49e-20115
anterior region of body2.89e-20129
craniocervical region2.89e-20129
anterior neural tube6.12e-2042
ectoderm1.73e-19173
presumptive ectoderm1.73e-19173
cell layer4.24e-19312
epithelium4.42e-19309
gray matter3.32e-1834
brain grey matter3.32e-1834
telencephalon7.14e-1834
multi-cellular organism8.36e-18659
regional part of telencephalon2.98e-1733
cerebral hemisphere4.44e-1732
vasculature8.46e-1679
vascular system8.46e-1679
organism subdivision1.03e-15365
anatomical system5.34e-15625
anatomical group8.55e-15626
vessel1.36e-1369
blood vessel1.16e-1260
epithelial tube open at both ends1.16e-1260
blood vasculature1.16e-1260
vascular cord1.16e-1260
cerebral cortex2.22e-1225
pallium2.22e-1225
circulatory system3.68e-12113
multi-tissue structure8.16e-12347
posterior neural tube1.97e-1115
chordal neural plate1.97e-1115
cardiovascular system2.09e-11110
regional part of cerebral cortex2.44e-1122
neocortex1.39e-1020
splanchnic layer of lateral plate mesoderm2.95e-1084
segmental subdivision of nervous system4.07e-1013
embryo5.23e-10612
aorta6.31e-1021
aortic system6.31e-1021
artery1.43e-0942
arterial blood vessel1.43e-0942
arterial system1.43e-0942
segmental subdivision of hindbrain2.23e-0912
hindbrain2.23e-0912
presumptive hindbrain2.23e-0912
smooth muscle tissue1.30e-0815
systemic artery5.24e-0833
systemic arterial system5.24e-0833
embryonic structure6.87e-08605
developing anatomical structure6.87e-08605
germ layer1.07e-07604
embryonic tissue1.07e-07604
presumptive structure1.07e-07604
epiblast (generic)1.07e-07604
nucleus of brain1.74e-079
neural nucleus1.74e-079
organ part1.84e-07219
epithelial tube1.91e-07118
blood vessel smooth muscle2.66e-0710
arterial system smooth muscle2.66e-0710
artery smooth muscle tissue2.66e-0710
aorta smooth muscle tissue2.66e-0710
muscle tissue3.87e-0763
musculature3.87e-0763


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.