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Coexpression cluster:C1700

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Full id: C1700_heart_adipose_mature_breast_left_smooth_vagina



Phase1 CAGE Peaks

Hg19::chr13:113633620..113633695,+p2@MCF2L
Hg19::chr1:112903200..112903261,-p1@ENST00000427290
Hg19::chr4:54518619..54518649,-p5@LNX1
Hg19::chr8:38586068..38586128,+p3@TACC1
Hg19::chr9:124062100..124062115,+p2@GSN


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0051014actin filament severing0.0340117855475839
GO:0005737cytoplasm0.0340117855475839
GO:0051693actin filament capping0.0340117855475839
GO:0051016barbed-end actin filament capping0.0340117855475839
GO:0030835negative regulation of actin filament depolymerization0.0340117855475839
GO:0030834regulation of actin filament depolymerization0.0340117855475839
GO:0030042actin filament depolymerization0.0340117855475839
GO:0030041actin filament polymerization0.036177181378452
GO:0008064regulation of actin polymerization and/or depolymerization0.036177181378452
GO:0051261protein depolymerization0.036177181378452
GO:0030832regulation of actin filament length0.036177181378452
GO:0032535regulation of cellular component size0.036177181378452
GO:0032956regulation of actin cytoskeleton organization and biogenesis0.036177181378452
GO:0051129negative regulation of cellular component organization and biogenesis0.036177181378452
GO:0051493regulation of cytoskeleton organization and biogenesis0.036177181378452
GO:0033043regulation of organelle organization and biogenesis0.036177181378452
GO:0008154actin polymerization and/or depolymerization0.0370810211729326



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fat cell1.82e-0815
Uber Anatomy
Ontology termp-valuen
adult organism1.37e-83114
neural tube1.64e-2956
neural rod1.64e-2956
future spinal cord1.64e-2956
neural keel1.64e-2956
regional part of nervous system5.91e-2753
regional part of brain5.91e-2753
regional part of forebrain2.86e-2241
forebrain2.86e-2241
anterior neural tube2.86e-2241
future forebrain2.86e-2241
brain1.39e-2168
future brain1.39e-2168
neural plate2.77e-2182
presumptive neural plate2.77e-2182
central nervous system3.53e-2181
neurectoderm1.74e-1986
nervous system1.54e-1889
structure with developmental contribution from neural crest3.58e-18132
brain grey matter3.96e-1734
gray matter3.96e-1734
organ system subdivision4.06e-17223
telencephalon4.44e-1734
regional part of telencephalon1.46e-1532
ecto-epithelium2.02e-15104
anatomical cluster2.14e-15373
cerebral hemisphere2.97e-1532
multi-tissue structure1.69e-14342
anatomical conduit1.14e-13240
pre-chordal neural plate1.61e-1361
regional part of cerebral cortex1.84e-1222
ectoderm-derived structure7.81e-12171
ectoderm7.81e-12171
presumptive ectoderm7.81e-12171
organ6.15e-11503
neocortex6.35e-1120
multi-cellular organism1.98e-10656
cerebral cortex2.55e-1025
pallium2.55e-1025
tube2.36e-09192
neural nucleus5.22e-099
nucleus of brain5.22e-099
basal ganglion5.91e-099
nuclear complex of neuraxis5.91e-099
aggregate regional part of brain5.91e-099
collection of basal ganglia5.91e-099
cerebral subcortex5.91e-099
organ part6.44e-09218
posterior neural tube2.29e-0815
chordal neural plate2.29e-0815
telencephalic nucleus2.39e-077
anatomical system2.41e-07624
anatomical group2.90e-07625
brainstem4.33e-076
segmental subdivision of nervous system6.10e-0713
diencephalon7.11e-077
future diencephalon7.11e-077
compound organ7.19e-0768
embryonic structure7.91e-07564
epithelium8.31e-07306
germ layer9.78e-07560
germ layer / neural crest9.78e-07560
embryonic tissue9.78e-07560
presumptive structure9.78e-07560
germ layer / neural crest derived structure9.78e-07560
epiblast (generic)9.78e-07560


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.