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Coexpression cluster:C1223

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Full id: C1223_Retinal_tubular_Endothelial_placenta_small_temporal_duodenum



Phase1 CAGE Peaks

  Short description
Hg19::chr16:82068830..82068841,+ p6@HSD17B2
Hg19::chr16:82068851..82068864,+ p4@HSD17B2
Hg19::chr16:82068873..82068889,+ p3@HSD17B2
Hg19::chr16:82068905..82068918,+ p7@HSD17B2
Hg19::chr16:82068920..82068953,+ p2@HSD17B2
Hg19::chr16:82068960..82068995,+ p1@HSD17B2
Hg19::chr16:82068997..82069008,+ p5@HSD17B2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
epithelial cell1.41e-16253
endodermal cell1.72e-1358
embryonic cell3.60e-12250
endo-epithelial cell1.03e-0842
lymphangioblast1.80e-086
endothelial cell of lymphatic vessel1.80e-086
vascular lymphangioblast1.80e-086
metabolising cell2.26e-0712
endopolyploid cell2.26e-0712
parenchymal cell2.26e-0712
polyploid cell2.26e-0712
hepatocyte2.26e-0712
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure2.06e-19160
endoderm2.06e-19160
presumptive endoderm2.06e-19160
digestive system1.03e-18145
digestive tract1.03e-18145
primitive gut1.03e-18145
subdivision of digestive tract3.07e-18118
gut epithelium9.02e-1754
anatomical cluster1.37e-14373
intestine8.93e-1317
endo-epithelium1.69e-1182
pigment epithelium of eye2.46e-1111
exocrine gland4.52e-1131
exocrine system4.52e-1131
gland5.26e-1159
orifice6.16e-1136
epithelium of foregut-midgut junction1.22e-1025
anatomical boundary1.22e-1025
hepatobiliary system1.22e-1025
foregut-midgut junction1.22e-1025
septum transversum1.22e-1025
digestive tract diverticulum1.65e-1023
hindgut2.03e-1019
multi-tissue structure2.56e-10342
organism subdivision3.87e-10264
hepatic diverticulum6.94e-1022
liver primordium6.94e-1022
head1.15e-0956
gastrointestinal system2.23e-0925
subdivision of head2.37e-0949
eye2.62e-0921
visual system2.62e-0921
organ system subdivision2.75e-09223
cloaca9.17e-0914
anal region9.17e-0914
embryonic cloaca9.17e-0914
terminal part of digestive tract9.17e-0914
primitive urogenital sinus9.17e-0914
proctodeum9.17e-0914
sac1.06e-0826
sense organ1.20e-0824
sensory system1.20e-0824
entire sense organ system1.20e-0824
camera-type eye1.66e-0820
simple eye1.66e-0820
immature eye1.66e-0820
ocular region1.66e-0820
eyeball of camera-type eye1.66e-0820
optic cup1.66e-0820
optic vesicle1.66e-0820
eye primordium1.66e-0820
face1.73e-0822
liver3.15e-0819
digestive gland3.15e-0819
liver bud3.15e-0819
epithelial sac4.02e-0825
genitourinary system5.79e-0815
large intestine6.47e-0811
anterior region of body6.58e-0862
craniocervical region6.58e-0862
unilaminar epithelium2.76e-07148
immaterial anatomical entity4.12e-07117
epithelium of mucosa6.31e-078


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0462779
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.0723474
MA0017.10.380797
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.14.25487
MA0043.10.973609
MA0046.16.80804
MA0048.10.120314
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.0407081
MA0056.10
MA0057.12.41364
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.488375
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.887754
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.10.347695
MA0103.10.332048
MA0105.10.104569
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.10.45062
MA0113.10.665691
MA0114.11.36091
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.254954
MA0145.10.276317
MA0146.10.0127148
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.20.564239
MA0039.22.64992
MA0138.20.704862
MA0002.21.15032
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.0758925
MA0065.20.0828768
MA0150.11.10099
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.102476
MA0155.10.910701
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.10.0249953
MA0163.10.0167306
MA0164.10.678332
MA0080.23.39674
MA0018.20.650405
MA0099.20.572
MA0079.23.31082
MA0102.21.51913
MA0258.10.245543
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199774.258097958807543.93848941900192e-050.000735309074778588
EP300#203376.77394172622321.52695018318475e-065.86513976394382e-05
FOS#235378.99795530889442.09217725654467e-071.11881669480936e-05
FOSL2#2355716.93020060456172.50368126508949e-092.11897866810925e-07
FOXA1#3169711.08141974938554.86782131208363e-083.14598013621722e-06
POLR2A#543072.147453176558070.004747636447610280.02234412162372
SIN3A#2594275.408884726815147.3795239773719e-060.000211617272013384
SP1#666775.69838137814095.12280185510121e-060.000157266402982044



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.