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Coexpression cluster:C4089

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Full id: C4089_Renal_Mesenchymal_Fibroblast_Pericytes_acute_Preadipocyte_Urothelial



Phase1 CAGE Peaks

Hg19::chr22:19929284..19929333,+p1@COMT
Hg19::chr22:19929336..19929371,+p4@COMT
Hg19::chr22:19929386..19929400,+p2@COMT


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
vasculature4.54e-1378
vascular system4.54e-1378
epithelial vesicle1.15e-1278
vessel5.13e-1168
splanchnic layer of lateral plate mesoderm8.39e-1183
multilaminar epithelium1.10e-1083
dense mesenchyme tissue3.18e-1073
somite4.50e-1071
presomitic mesoderm4.50e-1071
presumptive segmental plate4.50e-1071
dermomyotome4.50e-1071
trunk paraxial mesoderm4.50e-1071
paraxial mesoderm7.27e-1072
presumptive paraxial mesoderm7.27e-1072
epithelial tube open at both ends8.10e-1059
blood vessel8.10e-1059
blood vasculature8.10e-1059
vascular cord8.10e-1059
artery1.54e-0942
arterial blood vessel1.54e-0942
arterial system1.54e-0942
skeletal muscle tissue2.39e-0962
striated muscle tissue2.39e-0962
myotome2.39e-0962
anatomical system4.60e-09624
mesoderm6.65e-09315
mesoderm-derived structure6.65e-09315
presumptive mesoderm6.65e-09315
anatomical group7.12e-09625
multi-cellular organism1.36e-08656
epithelial tube2.06e-08117
muscle tissue2.51e-0864
musculature2.51e-0864
musculature of body2.51e-0864
cardiovascular system4.31e-08109
cell layer1.12e-07309
circulatory system1.26e-07112
unilaminar epithelium2.30e-07148
trunk mesenchyme2.45e-07122
epithelium2.51e-07306
systemic artery3.60e-0733
systemic arterial system3.60e-0733
mesenchyme7.77e-07160
entire embryonic mesenchyme7.77e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190365686522258
CEBPB#105137.971147625824820.001974187055288560.0115411207314459
CHD2#1106310.34402283411690.0009033701102746880.00661249445941815
E2F1#186934.907389214879320.008460985347239390.0325988434234823
E2F4#1874312.66806031528440.0004917987006298980.00437802288570457
E2F6#187635.017155731697390.00791769806886330.0322951169152124
ELF1#199734.258097958807540.01295179875054610.046322828317807
ETS1#211339.728760922202340.001085840092584840.00763509415131406
GABPB1#255337.067683836182170.002832212825417420.0154380728222218
GTF2F1#2962312.73966087675770.0004835525047438590.0043468531625877
HDAC2#3066313.41562023662630.0004140761399857210.00391931284973434
HMGN3#932438.178547723350590.001827766942164210.0108874779942217
JUNB#3726330.61063265982113.4847716247536e-050.00068103679587882
JUND#372736.994663941871030.002921845042734990.0157029061091031
MXI1#460139.96157162875930.001011470541259020.0072121917019561
NFKB1#479035.488063424193840.006049381815655430.0270007858218402
PAX5#507936.669565531177830.003370290999677260.0173180724091165
POU2F2#545239.106124057742520.001324165192682130.0088333219569832
REST#597839.650028716128020.001112636247114590.00768942674777664
SIN3A#2594235.408884726815140.006318961977991520.0277311568207184
SMC3#9126315.04493284493280.0002935825420371870.00309649233567176
SRF#6722313.79717826216780.0003806615025800190.00375622700944393
STAT1#6772320.70658749719920.0001125992441046670.00154998714314581
YY1#752834.911170749853860.008441455341808260.0329983588892133



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.