MCL coexpression mm9:558

Phase1 CAGE Peaks

	Short description
Mm9::chr11:102807325..102807370,-	p@chr11:102807325..102807370 -
Mm9::chr11:102808015..102808039,-	p1@C1ql1
Mm9::chr11:102808055..102808065,-	p2@C1ql1
Mm9::chr11:102808083..102808092,-	p3@C1ql1
Mm9::chr17:25932584..25932609,-	p@chr17:25932584..25932609 -
Mm9::chr17:25933909..25933926,-	p1@Metrn
Mm9::chr17:25933977..25934020,-	p2@Metrn
Mm9::chr18:60760090..60760115,-	p9@Synpo
Mm9::chr1:137051218..137051263,+	p@chr1:137051218..137051263 +
Mm9::chr2:30663055..30663094,-	p@chr2:30663055..30663094 -
Mm9::chr3:28164152..28164169,-	p@chr3:28164152..28164169 -
Mm9::chr7:4703765..4703780,-	p@chr7:4703765..4703780 -
Mm9::chr9:43880279..43880294,+	p@chr9:43880279..43880294 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0030865	cortical cytoskeleton organization and biogenesis	0.0480374230474727
GO:0043197	dendritic spine	0.0480374230474727
GO:0050772	positive regulation of axonogenesis	0.0480374230474727
GO:0050769	positive regulation of neurogenesis	0.0480374230474727

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
neural cell	2.66e-22	43
ectodermal cell	1.36e-21	44
neurectodermal cell	1.36e-21	44
non-terminally differentiated cell	1.72e-18	49
neuron	2.36e-15	33
neuronal stem cell	2.36e-15	33
neuroblast	2.36e-15	33
electrically signaling cell	2.36e-15	33
electrically responsive cell	4.95e-12	39
electrically active cell	4.95e-12	39
CNS neuron (sensu Vertebrata)	1.24e-08	23
neuroblast (sensu Vertebrata)	1.24e-08	23
migratory neural crest cell	5.49e-08	10
neuron associated cell	5.49e-08	10
glial cell (sensu Vertebrata)	5.49e-08	10
neuron associated cell (sensu Vertebrata)	5.49e-08	10
glial cell	5.49e-08	10
glioblast	5.49e-08	10
glioblast (sensu Vertebrata)	5.49e-08	10
autonomic neuron	7.29e-08	9
oligodendrocyte precursor cell	1.73e-07	8
embryonic cell	9.80e-07	70

Uber Anatomy

Ontology term	p-value	n
nervous system	2.38e-35	75
central nervous system	1.98e-34	73
ectoderm-derived structure	1.21e-33	95
ectoderm	1.21e-33	95
presumptive ectoderm	1.21e-33	95
neurectoderm	1.86e-25	64
neural plate	1.86e-25	64
presumptive neural plate	1.86e-25	64
ecto-epithelium	1.77e-21	73
regional part of nervous system	3.71e-20	54
structure with developmental contribution from neural crest	4.28e-19	92
neural tube	7.97e-19	52
neural rod	7.97e-19	52
future spinal cord	7.97e-19	52
neural keel	7.97e-19	52
brain	8.83e-16	47
future brain	8.83e-16	47
pre-chordal neural plate	1.02e-15	49
regional part of brain	3.54e-15	46
anterior neural tube	9.73e-12	40
gray matter	2.15e-11	34
regional part of forebrain	3.35e-11	39
forebrain	3.35e-11	39
future forebrain	3.35e-11	39
brain grey matter	1.21e-08	29
regional part of telencephalon	1.21e-08	29
telencephalon	1.21e-08	29
posterior neural tube	1.92e-08	12
chordal neural plate	1.92e-08	12
peripheral nervous system	2.20e-08	11
autonomic nervous system	7.29e-08	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}