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Coexpression cluster:C2410

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Full id: C2410_medial_amygdala_brain_smallcell_putamen_cerebellum_parietal



Phase1 CAGE Peaks

  Short description
Hg19::chr17:42390503..42390533,+ p@chr17:42390503..42390533
+
Hg19::chr19:55686309..55686319,- p@chr19:55686309..55686319
-
Hg19::chr1:110738238..110738245,+ p5@SLC6A17
Hg19::chr1:110740082..110740093,+ p@chr1:110740082..110740093
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
regional part of nervous system7.03e-7953
regional part of brain7.03e-7953
neural tube2.18e-7856
neural rod2.18e-7856
future spinal cord2.18e-7856
neural keel2.18e-7856
regional part of forebrain5.65e-6941
forebrain5.65e-6941
anterior neural tube5.65e-6941
future forebrain5.65e-6941
central nervous system1.41e-6581
brain1.55e-6568
future brain1.55e-6568
brain grey matter4.86e-6434
gray matter4.86e-6434
telencephalon6.07e-6434
cerebral hemisphere4.13e-5932
regional part of telencephalon1.29e-5832
nervous system5.19e-5889
regional part of cerebral cortex3.86e-5622
neural plate3.98e-5382
presumptive neural plate3.98e-5382
neocortex1.18e-5020
neurectoderm3.53e-5086
cerebral cortex5.76e-4925
pallium5.76e-4925
pre-chordal neural plate1.14e-4661
adult organism2.77e-44114
ecto-epithelium4.00e-44104
structure with developmental contribution from neural crest1.88e-32132
ectoderm-derived structure1.80e-29171
ectoderm1.80e-29171
presumptive ectoderm1.80e-29171
organ system subdivision5.96e-21223
tube4.11e-20192
gyrus2.07e-196
basal ganglion1.70e-169
nuclear complex of neuraxis1.70e-169
aggregate regional part of brain1.70e-169
collection of basal ganglia1.70e-169
cerebral subcortex1.70e-169
parietal lobe2.40e-165
temporal lobe3.25e-166
neural nucleus3.66e-169
nucleus of brain3.66e-169
limbic system7.32e-165
anatomical conduit6.38e-14240
corpus striatum2.63e-134
striatum2.63e-134
ventral part of telencephalon2.63e-134
future corpus striatum2.63e-134
brainstem2.92e-126
posterior neural tube8.57e-1215
chordal neural plate8.57e-1215
organ part1.40e-11218
segmental subdivision of hindbrain1.51e-1112
hindbrain1.51e-1112
presumptive hindbrain1.51e-1112
telencephalic nucleus4.42e-117
epithelium1.09e-10306
segmental subdivision of nervous system1.41e-1013
frontal cortex1.61e-103
cell layer1.78e-10309
caudate-putamen2.01e-103
dorsal striatum2.01e-103
occipital lobe3.29e-105
pons7.79e-103
anatomical cluster8.76e-10373
regional part of metencephalon1.62e-089
metencephalon1.62e-089
future metencephalon1.62e-089
amygdala1.40e-072
middle temporal gyrus1.50e-072
middle frontal gyrus1.54e-072
caudate nucleus2.55e-072
future caudate nucleus2.55e-072
diencephalon3.15e-077
future diencephalon3.15e-077
multi-tissue structure3.76e-07342
locus ceruleus3.94e-072
brainstem nucleus3.94e-072
hindbrain nucleus3.94e-072
Ammon's horn4.45e-072
lobe parts of cerebral cortex4.45e-072
hippocampal formation4.45e-072
limbic lobe4.45e-072
pituitary gland4.59e-072
meninx8.14e-072
membrane organ8.14e-072
meningeal cluster8.14e-072


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.720743
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.11.41335
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.11.52107
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.18043
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.11.54523
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.70272
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.483275
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.21.65877
MA0065.21.7213
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.12.08227
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.327251
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
HNF4A#3172211.56614518147680.01057585681762490.0390694319329323
HNF4G#3174214.37671126322340.006924169980439180.0293047529516184



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.