Coexpression cluster:C1971

Full id: C1971_spleen_Endothelial_heart_lung_adipose_mature_locus

Phase1 CAGE Peaks

Hg19::chr6:151004729..151004751,+	p7@PLEKHG1
Hg19::chr6:151004757..151004770,+	p12@PLEKHG1
Hg19::chr6:151004774..151004794,+	p4@PLEKHG1
Hg19::chr6:151004802..151004822,+	p3@PLEKHG1
Hg19::chr6:151004835..151004845,+	p15@PLEKHG1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	2.13e-24	24
endothelial cell	3.49e-22	35
blood vessel endothelial cell	3.72e-18	18
embryonic blood vessel endothelial progenitor cell	3.72e-18	18
meso-epithelial cell	1.99e-15	44
lining cell	1.13e-09	57
barrier cell	1.13e-09	57
endothelial cell of artery	1.27e-09	9
lymphangioblast	8.25e-08	6
endothelial cell of lymphatic vessel	8.25e-08	6
vascular lymphangioblast	8.25e-08	6
vein endothelial cell	2.17e-07	6
aortic endothelial cell	5.50e-07	6

Uber Anatomy

Ontology term	p-value	n
adult organism	6.61e-72	115
neural tube	1.24e-38	57
neural rod	1.24e-38	57
future spinal cord	1.24e-38	57
neural keel	1.24e-38	57
regional part of brain	2.98e-31	59
anterior neural tube	4.38e-31	42
regional part of forebrain	2.74e-30	41
forebrain	2.74e-30	41
future forebrain	2.74e-30	41
anatomical conduit	1.73e-27	241
brain	2.18e-27	69
future brain	2.18e-27	69
neural plate	1.06e-26	86
presumptive neural plate	1.06e-26	86
central nervous system	2.69e-26	82
gray matter	9.20e-26	34
brain grey matter	9.20e-26	34
tube	3.29e-25	194
telencephalon	3.45e-25	34
neurectoderm	1.24e-24	90
regional part of telencephalon	1.96e-24	33
cerebral hemisphere	1.92e-23	32
anatomical cluster	3.20e-23	286
regional part of nervous system	3.33e-22	94
nervous system	3.33e-22	94
regional part of cerebral cortex	2.45e-20	22
neocortex	2.64e-18	20
pre-chordal neural plate	3.25e-18	61
endothelium	3.72e-18	18
blood vessel endothelium	3.72e-18	18
cardiovascular system endothelium	3.72e-18	18
cerebral cortex	4.86e-17	25
pallium	4.86e-17	25
anterior region of body	2.02e-14	129
craniocervical region	2.02e-14	129
simple squamous epithelium	1.15e-13	22
head	3.56e-13	123
epithelium	3.69e-13	309
cell layer	9.56e-13	312
anatomical system	9.67e-13	625
anatomical group	1.22e-12	626
multi-cellular organism	3.06e-12	659
squamous epithelium	2.81e-11	25
ectoderm-derived structure	6.64e-11	169
nucleus of brain	1.76e-10	9
neural nucleus	1.76e-10	9
basal ganglion	2.72e-10	9
nuclear complex of neuraxis	2.72e-10	9
aggregate regional part of brain	2.72e-10	9
collection of basal ganglia	2.72e-10	9
cerebral subcortex	2.72e-10	9
ectoderm	3.13e-10	173
presumptive ectoderm	3.13e-10	173
endothelial tube	1.27e-09	9
arterial system endothelium	1.27e-09	9
endothelium of artery	1.27e-09	9
embryo	3.77e-09	612
brainstem	4.00e-09	8
organ	5.41e-09	511
embryonic structure	6.27e-09	605
developing anatomical structure	6.27e-09	605
posterior neural tube	1.03e-08	15
chordal neural plate	1.03e-08	15
germ layer	1.36e-08	604
embryonic tissue	1.36e-08	604
presumptive structure	1.36e-08	604
epiblast (generic)	1.36e-08	604
temporal lobe	1.46e-08	7
telencephalic nucleus	2.53e-08	7
vessel	2.59e-08	69
organ part	1.02e-07	219
vein	2.37e-07	9
venous blood vessel	2.37e-07	9
venous system	2.37e-07	9
segmental subdivision of nervous system	5.88e-07	13
gyrus	6.12e-07	6

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOS#2353	5	8.9979553088944	1.69470025615156e-05	0.000389766130923173
GATA2#2624	5	12.744931733554	2.9719152914525e-06	0.000101366381817116
JUN#3725	5	12.5128291923363	3.25800591331781e-06	0.000109268747456968
MAX#4149	5	6.45255550900712	8.93743970843928e-05	0.00130785661441739

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.