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Coexpression cluster:C4588

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Full id: C4588_neuroblastoma_neuroectodermal_osteosarcoma_medulloblastoma_acute_mesothelioma_small



Phase1 CAGE Peaks

  Short description
Hg19::chr6:30525051..30525063,+ p3@PRR3
Hg19::chr6:30525064..30525098,+ p1@PRR3
Hg19::chr6:30525100..30525120,+ p2@PRR3


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
nervous system4.72e-1589
central nervous system8.30e-1381
neurectoderm1.94e-1186
brain3.48e-1168
future brain3.48e-1168
organ system subdivision4.87e-11223
neural plate9.58e-1082
presumptive neural plate9.58e-1082
neural tube2.17e-0956
neural rod2.17e-0956
future spinal cord2.17e-0956
neural keel2.17e-0956
regional part of nervous system3.08e-0953
regional part of brain3.08e-0953
anatomical cluster2.70e-08373
pre-chordal neural plate5.89e-0861
regional part of cerebral cortex8.27e-0822
ectoderm-derived structure1.28e-07171
ectoderm1.28e-07171
presumptive ectoderm1.28e-07171
neocortex2.25e-0720
cerebral cortex2.65e-0725
pallium2.65e-0725
regional part of forebrain3.48e-0741
forebrain3.48e-0741
anterior neural tube3.48e-0741
future forebrain3.48e-0741
Disease
Ontology termp-valuen
cancer6.26e-33235
disease of cellular proliferation1.91e-32239
cell type cancer1.16e-16143
hematologic cancer8.77e-1551
immune system cancer8.77e-1551
organ system cancer6.72e-14137
leukemia1.18e-1239
carcinoma8.62e-11106
myeloid leukemia1.47e-0931


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.13.88968
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.15.6086
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.12.19699
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.11.38767
MA0148.13.29283
MA0149.10.884158
MA0062.25.16585
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.23.66129
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0107199
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.00129986080467452
BCLAF1#9774321.65264761012189.8473954032885e-050.00139451136071057
CHD2#1106310.34402283411690.0009033701102746880.00662549655526532
E2F6#187635.017155731697390.00791769806886330.0324052225336631
EGR1#195834.988179094810140.008056488137383440.0322207078417779
ELF1#199734.258097958807540.01295179875054610.0464628485456079
ELK4#2005316.2356816584680.0002336043955745990.00256302232056051
ETS1#211339.728760922202340.001085840092584840.0076484827294441
FOXA1#3169311.08141974938550.000734755275698670.00583774106037986
FOXA2#3170324.63046375266526.68983856509345e-050.00107638276059127
GABPB1#255337.067683836182170.002832212825417420.0154744167027868
HDAC2#3066313.41562023662630.0004140761399857210.0039324995893397
HNF4G#3174328.75342252644684.20470658818262e-050.000760012723023892
MAX#414936.452555509007120.003721913834265510.0187304466311789
MXI1#460139.96157162875930.001011470541259020.00722847761451697
MYC#460935.22228187160940.007020843755740150.0295844220700321
NFKB1#479035.488063424193840.006049381815655430.0270690397362998
NR2C2#7182332.61461090524092.88098172333076e-050.000606137893237191
REST#597839.650028716128020.001112636247114590.0077088109998939
RFX5#5993312.04791082719510.0005717246050312580.004864782957867
RXRA#6256320.07461713913330.0001235730348432220.00165906211415237
SIN3A#2594235.408884726815140.006318961977991520.0278082786962522
SIX5#147912317.0867153554590.0002004060546325010.00240273308917045
SPI1#668838.204323508522730.001810593189410520.0109380230280452
SRF#6722313.79717826216780.0003806615025800190.00376226996006005
TRIM28#10155318.59052504526250.0001555969297255280.00197934077266801
USF1#739136.361499277207960.00388404057290560.0191053745946537
USF2#7392312.99219738506960.0004558979393427810.00422817910372265
WRNIP1#568973109.8199643493767.53682839543883e-073.33250982553444e-05
YY1#752834.911170749853860.008441455341808260.0331036780731118
ZBTB7A#5134137.35190930787590.002516255860282270.0140810826658104
ZNF263#1012738.221841637010680.001799043925565870.0110031827443297



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.