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{{Coexpression_clusters
{
|full_id=C2911_Monocytederived_Macrophage_corpus_spinal_CD14_diencephalon_insula

Latest revision as of 12:15, 17 September 2013


Full id: C2911_Monocytederived_Macrophage_corpus_spinal_CD14_diencephalon_insula



Phase1 CAGE Peaks

Hg19::chr7:99764744..99764756,-p7@GAL3ST4
Hg19::chr7:99764761..99764795,-p4@GAL3ST4
Hg19::chr7:99764796..99764842,-p2@GAL3ST4
Hg19::chr7:99764857..99764886,-p3@GAL3ST4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
macrophage2.01e-106
Uber Anatomy
Ontology termp-valuen
adult organism6.93e-72114
neural tube9.69e-4756
neural rod9.69e-4756
future spinal cord9.69e-4756
neural keel9.69e-4756
regional part of nervous system2.17e-4253
regional part of brain2.17e-4253
central nervous system5.76e-3781
regional part of forebrain8.90e-3741
forebrain8.90e-3741
anterior neural tube8.90e-3741
future forebrain8.90e-3741
neural plate3.31e-3382
presumptive neural plate3.31e-3382
brain4.42e-3368
future brain4.42e-3368
nervous system1.18e-3189
neurectoderm6.42e-3186
telencephalon1.12e-2934
brain grey matter2.72e-2934
gray matter2.72e-2934
regional part of telencephalon8.70e-2732
cerebral hemisphere1.06e-2632
pre-chordal neural plate4.79e-2461
ecto-epithelium7.43e-23104
organ system subdivision6.66e-22223
regional part of cerebral cortex1.99e-2122
structure with developmental contribution from neural crest4.43e-21132
neocortex1.22e-1820
cerebral cortex3.16e-1825
pallium3.16e-1825
organ1.27e-15503
ectoderm-derived structure1.58e-15171
ectoderm1.58e-15171
presumptive ectoderm1.58e-15171
basal ganglion3.30e-139
neural nucleus3.30e-139
nuclear complex of neuraxis3.30e-139
nucleus of brain3.30e-139
aggregate regional part of brain3.30e-139
collection of basal ganglia3.30e-139
cerebral subcortex3.30e-139
anatomical cluster4.15e-13373
tube6.79e-12192
embryonic structure2.29e-11564
embryo2.42e-11592
germ layer3.55e-11560
germ layer / neural crest3.55e-11560
embryonic tissue3.55e-11560
presumptive structure3.55e-11560
germ layer / neural crest derived structure3.55e-11560
epiblast (generic)3.55e-11560
developing anatomical structure4.22e-11581
posterior neural tube6.16e-1115
chordal neural plate6.16e-1115
anatomical conduit6.92e-11240
organ part9.03e-11218
telencephalic nucleus1.19e-107
multi-tissue structure1.27e-10342
multi-cellular organism1.54e-10656
anatomical system4.07e-10624
anatomical group4.78e-10625
brainstem1.00e-096
limbic system1.38e-085
diencephalon1.73e-087
future diencephalon1.73e-087
temporal lobe7.18e-086
regional part of diencephalon2.77e-074
segmental subdivision of hindbrain3.77e-0712
hindbrain3.77e-0712
presumptive hindbrain3.77e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.13.70332
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.14.01633
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.92815
MA0145.10.195821
MA0146.10.221129
MA0147.11.16748
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.21.83323
MA0039.20.483275
MA0138.20.928035
MA0002.20.379056
MA0137.21.37305
MA0104.21.01696
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0626799
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.