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{{Coexpression_clusters
{
|full_id=C3340_occipital_temporal_brain_hippocampus_cerebellum_substantia_parietal

Latest revision as of 12:24, 17 September 2013


Full id: C3340_occipital_temporal_brain_hippocampus_cerebellum_substantia_parietal



Phase1 CAGE Peaks

Hg19::chr12:86578513..86578516,-p@chr12:86578513..86578516
-
Hg19::chr6:124231666..124231669,+p@chr6:124231666..124231669
+
Hg19::chr9:8339833..8339834,-p@chr9:8339833..8339834
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube2.88e-8056
neural rod2.88e-8056
future spinal cord2.88e-8056
neural keel2.88e-8056
regional part of nervous system3.67e-7553
regional part of brain3.67e-7553
central nervous system5.31e-6381
neural plate6.06e-6382
presumptive neural plate6.06e-6382
brain3.77e-6068
future brain3.77e-6068
neurectoderm1.18e-5986
nervous system1.82e-5989
brain grey matter3.21e-5134
gray matter3.21e-5134
telencephalon5.06e-5134
regional part of forebrain2.48e-5041
forebrain2.48e-5041
anterior neural tube2.48e-5041
future forebrain2.48e-5041
ecto-epithelium5.94e-48104
regional part of telencephalon8.88e-4532
cerebral hemisphere1.55e-4432
adult organism3.46e-43114
structure with developmental contribution from neural crest1.29e-40132
pre-chordal neural plate2.78e-3861
regional part of cerebral cortex8.58e-3722
cerebral cortex3.92e-3225
pallium3.92e-3225
posterior neural tube5.55e-3115
chordal neural plate5.55e-3115
ectoderm-derived structure8.95e-31171
ectoderm8.95e-31171
presumptive ectoderm8.95e-31171
segmental subdivision of nervous system4.37e-3013
neocortex5.31e-3020
segmental subdivision of hindbrain2.62e-2612
hindbrain2.62e-2612
presumptive hindbrain2.62e-2612
organ system subdivision6.05e-26223
brainstem8.71e-246
tube4.69e-22192
neural nucleus2.90e-219
nucleus of brain2.90e-219
organ part4.51e-17218
gyrus9.78e-176
regional part of metencephalon3.33e-169
metencephalon3.33e-169
future metencephalon3.33e-169
anatomical conduit5.97e-16240
basal ganglion6.32e-169
nuclear complex of neuraxis6.32e-169
aggregate regional part of brain6.32e-169
collection of basal ganglia6.32e-169
cerebral subcortex6.32e-169
anatomical cluster1.45e-15373
telencephalic nucleus2.33e-147
limbic system1.28e-135
epithelium1.95e-13306
cell layer3.22e-13309
multi-tissue structure7.58e-13342
pons8.69e-133
medulla oblongata9.43e-133
myelencephalon9.43e-133
future myelencephalon9.43e-133
Ammon's horn1.05e-092
lobe parts of cerebral cortex1.05e-092
hippocampal formation1.05e-092
limbic lobe1.05e-092
dorsal plus ventral thalamus1.14e-092
thalamic complex1.14e-092
temporal lobe1.88e-096
corpus striatum2.14e-094
striatum2.14e-094
ventral part of telencephalon2.14e-094
future corpus striatum2.14e-094
multi cell component structure2.75e-092
neuron projection bundle2.75e-092
middle temporal gyrus3.83e-092
locus ceruleus3.83e-092
brainstem nucleus3.83e-092
hindbrain nucleus3.83e-092
occipital lobe2.30e-085
parietal lobe7.03e-085
cerebellum5.40e-076
rhombic lip5.40e-076
organ5.73e-07503
embryo9.07e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.13.27048
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.13.36539
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.