Coexpression cluster:C2035

Full id: C2035_hippocampus_parietal_spinal_amygdala_middle_Fibroblast_medial

Phase1 CAGE Peaks

Hg19::chr10:111765766..111765786,+	p10@ADD3
Hg19::chr10:111765775..111765802,-	p1@uc001kyr.1
Hg19::chr10:111765798..111765847,+	p4@ADD3
Hg19::chr10:111765852..111765862,+	p16@ADD3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005200	structural constituent of cytoskeleton	0.0311285764747439
GO:0005516	calmodulin binding	0.0311285764747439

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	1.99e-22	180
fibroblast	4.86e-15	75
muscle precursor cell	4.97e-10	57
myoblast	4.97e-10	57
multi-potent skeletal muscle stem cell	4.97e-10	57
muscle cell	1.99e-09	54
contractile cell	4.20e-09	59
electrically responsive cell	1.88e-08	60
electrically active cell	1.88e-08	60
smooth muscle cell	2.69e-07	42
smooth muscle myoblast	2.69e-07	42
vascular associated smooth muscle cell	3.57e-07	32

Uber Anatomy

Ontology term	p-value	n
neural tube	3.79e-27	57
neural rod	3.79e-27	57
future spinal cord	3.79e-27	57
neural keel	3.79e-27	57
regional part of brain	1.08e-26	59
central nervous system	2.45e-25	82
brain	4.17e-25	69
future brain	4.17e-25	69
regional part of nervous system	2.64e-23	94
nervous system	2.64e-23	94
adult organism	4.68e-23	115
regional part of forebrain	1.98e-22	41
forebrain	1.98e-22	41
future forebrain	1.98e-22	41
anterior neural tube	4.03e-22	42
organism subdivision	7.25e-22	365
neural plate	1.04e-21	86
presumptive neural plate	1.04e-21	86
neurectoderm	8.90e-21	90
head	2.51e-19	123
anterior region of body	8.12e-19	129
craniocervical region	8.12e-19	129
telencephalon	8.98e-19	34
gray matter	9.43e-19	34
brain grey matter	9.43e-19	34
regional part of telencephalon	3.79e-18	33
cerebral hemisphere	1.43e-17	32
ectoderm-derived structure	6.87e-17	169
pre-chordal neural plate	9.13e-17	61
multi-tissue structure	1.47e-16	347
ectoderm	1.59e-16	173
presumptive ectoderm	1.59e-16	173
cell layer	2.49e-16	312
tube	1.15e-15	194
epithelium	1.20e-15	309
regional part of cerebral cortex	2.85e-15	22
anatomical cluster	3.18e-14	286
neocortex	7.47e-14	20
anatomical conduit	1.35e-13	241
multi-cellular organism	2.02e-13	659
cerebral cortex	3.29e-13	25
pallium	3.29e-13	25
muscle tissue	3.48e-11	63
musculature	3.48e-11	63
musculature of body	3.48e-11	63
somite	5.11e-11	83
paraxial mesoderm	5.11e-11	83
presomitic mesoderm	5.11e-11	83
presumptive segmental plate	5.11e-11	83
trunk paraxial mesoderm	5.11e-11	83
presumptive paraxial mesoderm	5.11e-11	83
skeletal muscle tissue	9.68e-11	61
striated muscle tissue	9.68e-11	61
myotome	9.68e-11	61
anatomical system	1.19e-10	625
anatomical group	1.92e-10	626
dermomyotome	4.55e-10	70
organ	1.05e-08	511
embryo	2.42e-08	612
embryonic structure	6.71e-08	605
developing anatomical structure	6.71e-08	605
multilaminar epithelium	7.98e-08	82
germ layer	1.20e-07	604
embryonic tissue	1.20e-07	604
presumptive structure	1.20e-07	604
epiblast (generic)	1.20e-07	604
basal ganglion	2.92e-07	9
nuclear complex of neuraxis	2.92e-07	9
aggregate regional part of brain	2.92e-07	9
collection of basal ganglia	2.92e-07	9
cerebral subcortex	2.92e-07	9
organ part	3.46e-07	219
nucleus of brain	4.19e-07	9
neural nucleus	4.19e-07	9
heart	6.64e-07	24
primitive heart tube	6.64e-07	24
primary heart field	6.64e-07	24
anterior lateral plate mesoderm	6.64e-07	24
heart tube	6.64e-07	24
heart primordium	6.64e-07	24
cardiac mesoderm	6.64e-07	24
cardiogenic plate	6.64e-07	24
heart rudiment	6.64e-07	24

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.