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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.134609515403383,

Latest revision as of 11:53, 17 September 2013


Full id: C1832_small_occipital_dura_postcentral_Skeletal_retina_paracentral



Phase1 CAGE Peaks

Hg19::chr1:14219287..14219357,+p1@C1orf196
Hg19::chr1:14219382..14219413,+p2@C1orf196
Hg19::chr1:14220052..14220081,+p@chr1:14220052..14220081
+
Hg19::chr1:14220085..14220096,+p@chr1:14220085..14220096
+
Hg19::chr7:54610331..54610338,+p12@VSTM2A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism5.16e-73114
neural tube4.26e-5156
neural rod4.26e-5156
future spinal cord4.26e-5156
neural keel4.26e-5156
regional part of nervous system1.64e-4653
regional part of brain1.64e-4653
neurectoderm5.53e-4086
regional part of forebrain9.37e-4041
forebrain9.37e-4041
anterior neural tube9.37e-4041
future forebrain9.37e-4041
central nervous system6.60e-3881
neural plate9.63e-3882
presumptive neural plate9.63e-3882
brain9.20e-3768
future brain9.20e-3768
telencephalon4.70e-3634
brain grey matter4.90e-3634
gray matter4.90e-3634
cerebral hemisphere1.51e-3332
regional part of telencephalon4.17e-3332
nervous system1.27e-3289
structure with developmental contribution from neural crest4.17e-31132
ecto-epithelium9.21e-31104
neocortex2.37e-2820
regional part of cerebral cortex5.77e-2822
pre-chordal neural plate4.06e-2561
cerebral cortex5.93e-2425
pallium5.93e-2425
ectoderm-derived structure5.31e-23171
ectoderm5.31e-23171
presumptive ectoderm5.31e-23171
organ system subdivision1.92e-14223
neural nucleus8.73e-149
nucleus of brain8.73e-149
basal ganglion1.41e-139
nuclear complex of neuraxis1.41e-139
aggregate regional part of brain1.41e-139
collection of basal ganglia1.41e-139
cerebral subcortex1.41e-139
posterior neural tube3.44e-1215
chordal neural plate3.44e-1215
multi-tissue structure5.50e-12342
tube1.24e-11192
gyrus2.01e-116
telencephalic nucleus7.56e-117
brainstem1.55e-106
anatomical conduit3.15e-10240
anatomical cluster4.74e-10373
epithelium5.04e-10306
parietal lobe6.32e-105
cell layer9.41e-10309
organ part1.49e-09218
temporal lobe6.31e-096
segmental subdivision of hindbrain3.80e-0812
hindbrain3.80e-0812
presumptive hindbrain3.80e-0812
multi-cellular organism4.31e-08656
embryonic structure1.59e-07564
developing anatomical structure1.90e-07581
segmental subdivision of nervous system2.17e-0713
germ layer2.50e-07560
germ layer / neural crest2.50e-07560
embryonic tissue2.50e-07560
presumptive structure2.50e-07560
germ layer / neural crest derived structure2.50e-07560
epiblast (generic)2.50e-07560
embryo2.58e-07592
corpus striatum2.63e-074
striatum2.63e-074
ventral part of telencephalon2.63e-074
future corpus striatum2.63e-074


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.04569
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.11.18667
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.11.48918
MA0051.10.731787
MA0052.11.03442
MA0055.10.603517
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0469445
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.11.52322
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.938075
MA0145.11.39943
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0575907
MA0138.21.95446
MA0002.20.30855
MA0137.21.20193
MA0104.20.320919
MA0047.20.767096
MA0112.21.35805
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.11.91168
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.0850863
MA0102.21.66336
MA0258.10.914277
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.